Target
Ephrin type-A receptor 4 [29-209,M60A]
Ligand
BDBM223311
Substrate
n/a
Meas. Tech.
Isothermal Titration Calorimetry (ITC)
pH
6.5±0
Temperature
300.15±0 K
Kd
350±30 nM
Citation
 Wu, BDe, SKKulinich, ASalem, AFKoeppen, JWang, RBarile, EWang, SZhang, DEthell, IPellecchia, M Potent and Selective EphA4 Agonists for the Treatment of ALS. Cell Chem Biol 24:293-305 (2017) [PubMed]  Article 
Target
Name:
Ephrin type-A receptor 4 [29-209,M60A]
Synonyms:
EPHA4 | EPHA4_HUMAN | Ephrin type-A receptor 4 ligand binding domain (M60A-EphA4-LBD) | HEK8 | SEK | TYRO1
Type:
Protein
Mol. Mass.:
20790.32
Organism:
Homo sapiens (Human)
Description:
Human EphA4-LBD M60A mutant
Residue:
181
Sequence:
NEVTLLDSRSVQGELGWIASPLEGGWEEVSIADEKNTPIRTYQVCNVMEPSQNNWLRTDWITREGAQRVYIEIKFTLRDCNSLPGVMGTCKETFNLYYYESDNDKERFIRENQFVKIDTIAADESFTQVDIGDRIMKLNTEIRDVGPLSKKGFYLAFQDVGACIALVSVRVFYKKCPLTVR
  
Inhibitor
Name:
BDBM223311
Synonyms:
123C4
Type:
Small organic molecule
Emp. Form.:
C43H47ClN8O6
Mol. Mass.:
807.336
SMILES:
COc1ccc2[nH]cc(CCNC(=O)[C@H](Cc3ccncc3)NC(=O)[C@H](Cc3ccc(Cl)cc3)NC(=O)[C@H](Cc3c[nH]c4ccc(O)cc34)NC(=O)CCCN)c2c1 |r|
Structure:
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