Reaction Details Report a problem with these data
Target
Ephrin type-A receptor 4 [29-209,D61G,E62G]
Ligand
BDBM223311
Substrate
n/a
Meas. Tech.
Isothermal Titration Calorimetry (ITC)
pH
6.5±0
Temperature
300.15±0 K
Kd
340±40 nM
Citation
 Wu, B; De, SK; Kulinich, A; Salem, AF; Koeppen, J; Wang, R; Barile, E; Wang, S; Zhang, D; Ethell, I; Pellecchia, M Potent and Selective EphA4 Agonists for the Treatment of ALS. Cell Chem Biol 24:293-305 (2017) [PubMed]  Article 
Target
Name:
Ephrin type-A receptor 4 [29-209,D61G,E62G]
Synonyms:
EPHA4 | EPHA4_HUMAN | Ephrin type-A receptor 4 ligand binding domain (D61G/E62G-EphA4-LBD) | HEK8 | SEK | TYRO1
Type:
Protein
Mol. Mass.:
20722.36
Organism:
Homo sapiens (Human)
Description:
Human EphA4-LBD D61G/E62G double mutant
Residue:
181
Sequence:
NEVTLLDSRSVQGELGWIASPLEGGWEEVSIMGGKNTPIRTYQVCNVMEPSQNNWLRTDWITREGAQRVYIEIKFTLRDCNSLPGVMGTCKETFNLYYYESDNDKERFIRENQFVKIDTIAADESFTQVDIGDRIMKLNTEIRDVGPLSKKGFYLAFQDVGACIALVSVRVFYKKCPLTVR
  
Inhibitor
Name:
BDBM223311
Synonyms:
123C4
Type:
Small organic molecule
Emp. Form.:
C43H47ClN8O6
Mol. Mass.:
807.336
SMILES:
COc1ccc2[nH]cc(CCNC(=O)[C@H](Cc3ccncc3)NC(=O)[C@H](Cc3ccc(Cl)cc3)NC(=O)[C@H](Cc3c[nH]c4ccc(O)cc34)NC(=O)CCCN)c2c1 |r|
Structure:
Search PDB for entries with ligand similarity: