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Target
Ubiquitin carboxyl-terminal hydrolase 2 [258-605]
Ligand
BDBM53721
Substrate
n/a
Meas. Tech.
Di-UB K63-2 Hydrolysis Assay
IC50
>1.00e+5±n/a nM
Citation
 Magiera, K; Tomala, M; Kubica, K; De Cesare, V; Trost, M; Zieba, BJ; Kachamakova-Trojanowska, N; Les, M; Dubin, G; Holak, TA; Skalniak, L Lithocholic Acid Hydroxyamide Destabilizes Cyclin D1 and Induces G0/G1 Arrest by Inhibiting Deubiquitinase USP2a. Cell Chem Biol 24:458-470 (2017) [PubMed]  Article 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase 2 [258-605]
Synonyms:
UBP2_HUMAN | UBP41 | USP2 | Ubiquitin-specific peptidase 2a (USP2a)
Type:
Enzyme
Mol. Mass.:
40094.16
Organism:
Homo sapiens (Human)
Description:
Hman USP2a (258-605 aa)
Residue:
348
Sequence:
MNSKSAQGLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLHHGSNAHTALVEEFAKLIQTIWTSSPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVNRVTLRPKSNPENLDHLPDDEKGRQMWRKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFDPFWDLSLPIAKRGYPEVTLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIKKFSIQRFPKILVLHLKRFSESRIRTSKLTTFVNFPLRDLDLREFASENTNHAVYNLYAVSNHSGTTMGGHYTAYCRSPGTGEWHTFNDSSVTPMSSSQVRTSDAYLLFYELASPPSRM
  
Inhibitor
Name:
BDBM53721
Synonyms:
(4R)-4-[(3R,5S,7S,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-3,7-bis(oxidanyl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid | (4R)-4-[(3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid | (4R)-4-[(3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]valeric acid | (R)-4-((3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid | 3alpha,7beta-dihydroxycholanic acid | Actigall | CHEMBL1551 | MLS000028461 | SMR000058403 | UDCA | URSODEOXYCHOLIC ACID | URSODIOL | Urso 250 | Urso forte | Ursodesoxycholic Acid | cid_31401 | ursodeoxycholicacid
Type:
Small organic molecule
Emp. Form.:
C24H40O4
Mol. Mass.:
392.572
SMILES:
C[C@H](CCC(O)=O)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
Structure:
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