Reaction Details Report a problem with these data
Target
Prokineticin-2
Ligand
BDBM121129
Substrate
n/a
Meas. Tech.
Calcium Mobilization Assay
pH
7.5±n/a
Temperature
310.15±n/a K
IC50
40±0.0 nM
EC50
7.8±0 nM
Comments
extracted
Citation
 Chen, DN; Ma, YT; Liu, H; Zhou, QY; Li, JD Functional rescue of Kallmann syndrome-associated prokineticin receptor 2 (PKR2) mutants deficient in trafficking. J Biol Chem 289:15518-26 (2014) [PubMed]  Article 
Target
Name:
Prokineticin-2
Synonyms:
BV8 | PROK2 | PROK2_HUMAN | Prokineticin 2 (PK2)
Type:
Protein
Mol. Mass.:
14333.75
Organism:
Homo sapiens (Human)
Description:
Q9HC23
Residue:
129
Sequence:
MRSLCCAPLLLLLLLPPLLLTPRAGDAAVITGACDKDSQCGGGMCCAVSIWVKSIRICTPMGKLGDSCHPLTRKNNFGNGRQERRKRKRSKRKKEVPFFGRRMHHTCPCLPGLACLRTSFNRFICLAQK
  
Inhibitor
Name:
BDBM121129
Synonyms:
A457 | US8722896, (+/-)-1-Benzyl-N-(9-chloro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Type:
Small organic molecule
Emp. Form.:
C26H33ClN2O3
Mol. Mass.:
457.005
SMILES:
CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C1CCN(Cc2ccccc2)C1
Structure:
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