Reaction Details Report a problem with these data
Target
Isoform A1-A of Heterogeneous nuclear ribonucleoprotein A1 (A1-A)
Ligand
BDBM7460
Substrate
n/a
Meas. Tech.
Surface Plasmon Resonance (SPR) Assay
pH
4.0000±n/a
Kd
8.9e+3±n/a nM
Comments
extracted
Citation
 Ko, CC; Chen, YJ; Chen, CT; Liu, YC; Cheng, FC; Hsu, KC; Chow, LP Chemical proteomics identifies heterogeneous nuclear ribonucleoprotein (hnRNP) A1 as the molecular target of quercetin in its anti-cancer effects in PC-3 cells. J Biol Chem 289:22078-89 (2014) [PubMed]  Article 
Target
Name:
Isoform A1-A of Heterogeneous nuclear ribonucleoprotein A1 (A1-A)
Synonyms:
Heterogeneous nuclear ribonucleoprotein A1 (A1-A) | ROA1_HUMAN | HNRNPA1 | HNRPA1 | Heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1)
Type:
Protein
Mol. Mass.:
34206.88
Organism:
Human
Description:
P09651-2
Residue:
320
Sequence:
MSKSESPKEPEQLRKLFIGGLSFETTDESLRSHFEQWGTLTDCVVMRDPNTKRSRGFGFVTYATVEEVDAAMNARPHKVDGRVVEPKRAVSREDSQRPGAHLTVKKIFVGGIKEDTEEHHLRDYFEQYGKIEVIEIMTDRGSGKKRGFAFVTFDDHDSVDKIVIQKYHTVNGHNCEVRKALSKQEMASASSSQRGRSGSGNFGGGRGGGFGGNDNFGRGGNFSGRGGFGGSRGGGGYGGSGDGYNGFGNDGSNFGGGGSYNDFGNYNNQSSNFGPMKGGNFGGRSSGPYGGGGQYFAKPRNQGGYGGSSSSSSYGSGRRF
  
Inhibitor
Name:
BDBM7460
Synonyms:
2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-chromone;hydrate | 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one | CHEMBL50 | 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-chromen-4-one | Quercetin | Quercetin (21) | Quercetin (Qur) | US9180183, Quercetin | Quercetin (10) | med.21724, Compound 4 | US11021454, Compound Quercetin
Type:
Small organic molecule
Emp. Form.:
C15H10O7
Mol. Mass.:
302.04
SMILES:
c1cc(c(cc1C2=C(C(=O)c3c(cc(cc3O2)O)O)O)O)O
Structure:
Search PDB for entries with ligand similarity: