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Target
Fructose-bisphosphate aldolase
Ligand
BDBM237136
Substrate
n/a
Meas. Tech.
Enzymatic Assay
IC50
17000±2100 nM
Kd
6940±970 nM
Citation
 Pegan, SD; Ahrendt, K; Capodagli, GC; Cowen, B Antibiotic and anti-parasitic agents that modulate class II fructose 1,6-bisphosphate aldolase US Patent  US9394254 Publication Date 7/19/2016
Target
Name:
Fructose-bisphosphate aldolase
Synonyms:
FBP aldolase | FBPA | Fructose-1,6-bisphosphate aldolase | Fructose-1,6-bisphosphate aldolase (FBA) | Fructose-bisphosphate aldolase | Probable fructose-bisphosphate aldolase Fba
Type:
Protein
Mol. Mass.:
36539.01
Organism:
Mycobacterium tuberculosis (strain H37Rv)
Description:
P9WQA3
Residue:
344
Sequence:
MPIATPEVYAEMLGQAKQNSYAFPAINCTSSETVNAAIKGFADAGSDGIIQFSTGGAEFGSGLGVKDMVTGAVALAEFTHVIAAKYPVNVALHTDHCPKDKLDSYVRPLLAISAQRVSKGGNPLFQSHMWDGSAVPIDENLAIAQELLKAAAAAKIILEIEIGVVGGEEDGVANEINEKLYTSPEDFEKTIEALGAGEHGKYLLAATFGNVHGVYKPGNVKLRPDILAQGQQVAAAKLGLPADAKPFDFVFHGGSGSLKSEIEEALRYGVVKMNVDTDTQYAFTRPIAGHMFTNYDGVLKVDGEVGVKKVYDPRSYLKKAEASMSQRVVQACNDLHCAGKSLTH
  
Inhibitor
Name:
BDBM237136
Synonyms:
US9394254, 5 (HCA)
Type:
Small organic molecule
Emp. Form.:
C10H7NO3
Mol. Mass.:
189.1675
SMILES:
OC(=O)c1ccc2cccc(O)c2n1
Structure:
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