Reaction Details Report a problem with these data
Target
Retinoic acid receptor RXR-alpha [225-462]/Thyroid hormone receptor beta [148-410]
Ligand
BDBM237175
Substrate
n/a
Meas. Tech.
Recruitment Assay
pH
7±n/a
EC50
7040±n/a nM
Comments
extracted
Citation
 Haynes, N; Kertesz, DJ; Pietranico-Cole, SL; Qian, Y; Scott, NR; So, S; Thakkar, KC; Tilley, JW Thyroid hormone analogs US Patent  USRE46024 Publication Date 6/7/2016 
Target
Name:
Retinoic acid receptor RXR-alpha [225-462]/Thyroid hormone receptor beta [148-410]
Synonyms:
Thyroid Hormone Receptor Beta/ Retinoid X Receptor
Type:
Protein
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Thyroid hormone receptor beta [148-410]
Synonyms:
ERBA2 | NR1A2 | THB_HUMAN | THR1 | THRB | Thyroid hormone receptor beta
Type:
Protein
Mol. Mass.:
29766.52
Organism:
Homo sapiens (Human)
Description:
amino acids 148-410
Residue:
263
Sequence:
EGKCVIDKVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYR
  
Component 2
Name:
Retinoic acid receptor RXR-alpha [225-462]
Synonyms:
NR2B1 | RXRA | RXRA_HUMAN | Retinoic acid receptor RXR-alpha
Type:
Protein
Mol. Mass.:
26631.53
Organism:
Homo sapiens (Human)
Description:
amino acids 225-462
Residue:
238
Sequence:
SANEDMPVERILEAELAVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQMT
  
Inhibitor
Name:
BDBM237175
Synonyms:
USRE46024, 20
Type:
Small organic molecule
Emp. Form.:
C17H12Cl2N6O5S
Mol. Mass.:
483.285
SMILES:
CC(C)c1cc(n[nH]c1=O)S(=O)(=O)c1c(Cl)cc(cc1Cl)-n1nc(C#N)c(=O)[nH]c1=O
Structure:
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