Reaction Details
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Genome polyprotein [2420-3010,C2735L]
Ligand
BDBM243456
Substrate
n/a
Meas. Tech.
Surface Plasmon Resonance (SPR)-Based Assay
pH
7.4000±n/a
Temperature
298.1500±n/a K
Kd
2.2±n/a nM
KOFF
7.60E-05 s-1
KON
3.50E+04 M-1s-1
Comments
extracted
Citation
Vendeville, SM; Raboisson, PJ; Lin, T; Tahri, A; Amssoms, KI Macrocyclic indole derivatives useful as hepatitis C virus inhibitors US Patent US9427440 Publication Date 8/30/2016 More Info.:
Target
Name:
Genome polyprotein [2420-3010,C2735L]
Synonyms:
POLG_HCVJ4 | RNA-directed RNA polymerase (NS5B)(C316Y)
Type:
Enzyme
Mol. Mass.:
65843.39
Organism:
HCV
Description:
C316Y
Residue:
591
Sequence:
SMSYTWTGALITPCAAEETKLPINALSNSLLRHHNLVYATTSRSASLRQKKVTFDRLQVLDDHYRDVLKEMKAKASTVKAKLLSVEEACKLTPPHSARSKFGYGAKDVRNLSSKAVNHIRSVWKDLLEDTETPIDTTIMAKNEVFCVQPEKGGRKPARLIVFPDLGVRVCEKMALYDVVSTLPQAVMGSSYGFQYSPGQRVEFLVNAWKAKKCPMGFAYDTRCFDSTVTENDIRVEESIYQCCDLAPEARQAIRSLTERLYIGGPLTNSKGQNCGYRRCRASGVLTTSCGNTLTCYLKAAAACRAAKLQDCTMLVYGDDLVVICESAGTQEDEASLRAFTEAMTRYSAPPGDPPKPEYDLELITSCSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMYAPTLWARMILMTHFFSILLAQEQLEKALDCQIYGACYSIEPLDLPQIIQRLHGLSAFSLHSYSPGEINRVASCLRKLGVPPLRVWRHRARSVRARLLSQGGRAATCGKYLFNWAVRTKLKLTPIPAASQLDLSSWFVAGYSGGDIYHSLSRARPRWFMWCLLLLSVGVGIYLLPNR
Inhibitor
Name:
BDBM243456
Synonyms:
US9427440, 1
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
