Reaction Details Report a problem with these data
Target
Prokineticin receptor 1
Ligand
BDBM250604
Substrate
n/a
Meas. Tech.
Biological Assay
pH
7.4±n/a
Temperature
310.15±n/a K
IC50
730±n/a nM
Comments
extracted
Citation
 Carroll, C; Goldby, A; Teall, M Sulfonyl piperidine derivatives and their use for treating prokineticin mediated diseases US Patent  US9475795 Publication Date 10/25/2016 
Target
Name:
Prokineticin receptor 1
Synonyms:
G-protein coupled receptor 73 | G-protein coupled receptor ZAQ | GPR73 | GPR73a | PK-R1 | PKR1 | PKR1_HUMAN | PROKR1
Type:
enzyme
Mol. Mass.:
44779.92
Organism:
Homo sapiens (Human)
Description:
Q8TCW9
Residue:
393
Sequence:
METTMGFMDDNATNTSTSFLSVLNPHGAHATSFPFNFSYSDYDMPLDEDEDVTNSRTFFAAKIVIGMALVGIMLVCGIGNFIFIAALVRYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQLSWEHGHVLCTSVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKCQTATGLIALVWTVSILIAIPSAYFTTETVLVIVKSQEKIFCGQIWPVDQQLYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPGFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYGFTIVRDFFPTVFVKEKHYLTAFYIVECIAMSNSMINTLCFVTVKNDTVKYFKKIMLLHWKASYNGGKSSADLDLKTIGMPATEEVDCIRLK
  
Inhibitor
Name:
BDBM250604
Synonyms:
US10167273, Example 83 | US10544126, Example 83 | US11512066, Example 83 | US9475795, 83
Type:
Small organic molecule
Emp. Form.:
C18H23ClFN3O2S
Mol. Mass.:
399.911
SMILES:
Cc1nn(C)c(C)c1S(=O)(=O)N1CCC(Cc2ccc(Cl)cc2F)CC1
Structure:
Search PDB for entries with ligand similarity: