Target
Translocator protein
Ligand
BDBM50363527
Substrate
n/a
Meas. Tech.
In Vitro Potency Assay
pH
7.4±n/a
Ki
0.68±n/a nM
Comments
extracted
Citation
 Wadsworth, HJShan, BO'Shea, DPassmore, JMTrigg, WJ Imaging neuroinflammation US Patent  US9481685 Publication Date 11/1/2016 
Target
Name:
Translocator protein
Synonyms:
Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo
Type:
Mitochondrion membrane protein
Mol. Mass.:
18945.84
Organism:
Rattus norvegicus (rat)
Description:
Competitive binding experiments were performed on rat kidney mitochondrial membranes.
Residue:
169
Sequence:
MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAMGYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVATATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
  
Inhibitor
Name:
BDBM50363527
Synonyms:
CHEMBL1945412 | US9481685, [18F]FE-PBR
Type:
Small organic molecule
Emp. Form.:
C22H23FN2OS
Mol. Mass.:
382.494
SMILES:
CCN(CC)C(=O)C1Sc2ccccc2-c2c1c1ccccc1n2CCF
Structure:
Search PDB for entries with ligand similarity: