Reaction Details Report a problem with these data
Target
Bifunctional epoxide hydrolase 2
Ligand
BDBM25730
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
61.0±n/a nM
Citation
 Guedes, AG; Hammock, BD; Morisseau, C Treatment of inflammatory disorders in non-human mammals US Patent  US10383835 Publication Date 8/20/2019 
Target
Name:
Bifunctional epoxide hydrolase 2
Synonyms:
EPHX2 | HYES_PIG | Soluble Epoxide Hydrolase
Type:
n/a
Mol. Mass.:
62766.18
Organism:
Sus scrofa (Pig)
Description:
Q6Q2C2
Residue:
555
Sequence:
MALRAAVFDLDGVLALPSITTSWARAEEKLALPRGFLNEAFKKGGQDGSVARVMTGEITFSQWVPFMEEDCRKCAEDSGIRLPENFSVKHIFDKALSEKKINYPMLQAALTLKKKGFSTCILTNNWLDDSAQRGSRAQLMCELRPHFDFLIESCRVGMAKPDPQIYKLMLDTLKAEPNEVVFLDDVGTHLKPVRDLGMATILVRDTDTALRELEKVTGVQLLQTPALPPTSCDPSALSHGYVLIKPGVRLHFVEMGSGPAVCLCHGFPESWFSWRYQIPALAQAGFRVLAVDMKGYGESSAPPEIEEYSLEVLCKDMVTFLNKLGLSQAVFIGHDWGGVLVWNMALFYPERVRAVASLNTPFMPSNPNVSPMEIIKANPVFDYQLYFQEPGVAEAELEQNLDRTFKNFFRAHDETFLTTNRVRELGGLFVGTPEEPSLSRLVTEEDIQFYVQQFKKSGFRGPLNWYRNMERNWQWGCKGSGRKILIPALMVTAENDLVLHPKMSKHMENWIPHLKRGHIKDCGHWTQIDKPAELNRILIEWLETDARNPLVDSKL
  
Inhibitor
Name:
BDBM25730
Synonyms:
3-(4-chlorophenyl)-1-(3,4-dichlorophenyl)urea | US10383835, Compound 295 | US8815951, 3-(4-chlorophenyl)-1-(3,4-dichlorophenyl)urea | Urea-based compound, 11 | cid_7547
Type:
Small organic molecule
Emp. Form.:
C13H9Cl3N2O
Mol. Mass.:
315.582
SMILES:
Clc1ccc(NC(=O)Nc2ccc(Cl)c(Cl)c2)cc1
Structure:
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