Reaction Details Report a problem with these data
Target
Epoxide hydrolase
Ligand
BDBM100423
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
67.0±n/a nM
Citation
 Guedes, AG; Hammock, BD; Morisseau, C Treatment of inflammatory disorders in non-human mammals US Patent  US10383835 Publication Date 8/20/2019 
Target
Name:
Epoxide hydrolase
Synonyms:
EPHX1
Type:
Enzyme
Mol. Mass.:
52112.47
Organism:
Ovis aries (Sheep)
Description:
W5Q7Q6
Residue:
451
Sequence:
MWLEILLASVLGFVIYWFVSKDKEETLPLEDGWWGPGVRPTAGEDKSIRPFKVETSDEEINDLHQRIDRVRLTPPLEDSRFHYGFNSNYLKKIISYWRNEFDWRKQVEILNKYPHFKTKIEGLDIHFIHVKPPNLPSGQTPKPLLMVHGWPGSFYEFYKIIPLLTDPKNHGLSDEHVFEVICPSIPGYGFSEASSKKGFNSVATARIFYKLMLRLGFQKFYIQGGDWGALICTNMAQLVPSHIKGLHLNMALILRNFYTLTLPLGRCFGGLFGYTERDMELIYPFKKIFFSLLRESGYMHIQSTKPDTVGCALNDSPVGLAAYILEKFSTWTNSEFRDLEDGGLERKFSLDDLLTGIMLYWTTGTITSSQRFYKENLAQVNKHETLKVYVPTGFAAFPCELIHSPEKWVKTKYPKLISYSYMPRGGHFAAFEEPELLAQDIRKFVGLQERQ
  
Inhibitor
Name:
BDBM100423
Synonyms:
US10383835, Compound 1153 | US11123311, Compound APAU | US8501783, 1153
Type:
Small organic molecule
Emp. Form.:
C18H29N3O2
Mol. Mass.:
319.4418
SMILES:
CC(=O)N1CCC(CC1)NC(=O)NC12CC3CC(CC(C3)C1)C2 |TLB:22:13:20:16.17.18,THB:22:17:20:13.21.14,21:13:16:20.19.18,21:19:16:13.22.14,12:13:20:16.17.18|
Structure:
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