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Target
Interleukin-17A
Ligand
BDBM419218
Substrate
n/a
Meas. Tech.
I L-17A Secretion
IC50
<100±n/a nM
Citation
 Musicki, B; Bouix-Peter, C; Ouvry, G; Thoreau, E Benzenesulfonamide derivatives as inverse agonists of retinoid-related orphan receptor gamma (RORγ(T)) US Patent  US10457637 Publication Date 10/29/2019 
Target
Name:
Interleukin-17A
Synonyms:
CTLA8 | Cytotoxic T-lymphocyte-associated antigen 8 | IL-17 | IL17 | IL17A | IL17_HUMAN | il-17a
Type:
Enzyme Catalytic Domain
Mol. Mass.:
17511.44
Organism:
Homo sapiens (Human)
Description:
Q16552
Residue:
155
Sequence:
MTPGKTSLVSLLLLLSLEAIVKAGITIPRNPGCPNSEDKNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRREPPHCPNSFRLEKILVSVGCTCVTPIVHHVA
  
Inhibitor
Name:
BDBM419218
Synonyms:
4-((((1R,5S,6S)-3- oxabicyclo[3.1.0]hexan-6- yl)methyl)amino)-N-(4- ethylphenyl)-N-isobutyl-3- (S- methylsulfonimidoyl)benzene- sulfonamide | US10457637, Compound 91
Type:
Small organic molecule
Emp. Form.:
C25H35N3O4S2
Mol. Mass.:
505.693
SMILES:
CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NC[C@H]2[C@@H]3COC[C@H]23)c(c1)S(C)(=N)=O |r|
Structure:
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