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Target
5-hydroxytryptamine receptor 7
Ligand
BDBM426886
Substrate
n/a
Meas. Tech.
FLIPR Calcium Assay
EC50
700±n/a nM
Citation
 Ueng, S; Yeh, S; Lin, S; Shih, C; Loh, H Thiazolidinone compounds and use thereof US Patent  US10544113 Publication Date 1/28/2020 
Target
Name:
5-hydroxytryptamine receptor 7
Synonyms:
5-HT-7 | 5-HT-X | 5-HT7 | 5-HT7L | 5-HT7S | 5-HT7b | 5HT7 | 5HT7R_HUMAN | HTR7 | Serotonin receptor 7
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
53573.08
Organism:
Homo sapiens (Human)
Description:
P34969
Residue:
479
Sequence:
MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERPEFVLRACTRRVLLRPEKRPPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD
  
Inhibitor
Name:
BDBM426886
Synonyms:
US10544113, No. 188 | [1-(4-Chlorophenyl)cyclopropyl]methyl 4-[2-(4-fluorophenyl)-4-oxo-1,3-thiazolidin-3-yl]-3-methylbenzoate
Type:
Small organic molecule
Emp. Form.:
C24H21FN2O5S2
Mol. Mass.:
500.562
SMILES:
COc1ccc(cc1)S(=O)(=O)NC(=O)c1ccc(N2C(SCC2=O)c2ccc(F)cc2)c(C)c1
Structure:
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