Reaction Details Report a problem with these data
Target
Fibroblast growth factor 4
Ligand
BDBM249396
Substrate
n/a
Meas. Tech.
Kinase Activity Inhibition Assay
IC50
<1.000±n/a nM
Citation
 Moniz, G; Sanders, K; Chanda, A; Yoshida, K Crystalline FGFR4 inhibitor compound and uses thereof US Patent  US10562888 Publication Date 2/18/2020 
Target
Name:
Fibroblast growth factor 4
Synonyms:
FGF-4 | FGF4 | FGF4_HUMAN | HBGF-4 | HST | HST-1 | HSTF-1 | HSTF1 | Heparin secretory-transforming protein 1 | Heparin-binding growth factor 4 | KS3 | Transforming protein KS3
Type:
PROTEIN
Mol. Mass.:
22057.91
Organism:
Homo sapiens (Human)
Description:
ChEMBL_108374
Residue:
206
Sequence:
MSGPGTAAVALLPAVLLALLAPWAGRGGAAAPTAPNGTLEAELERRWESLVALSLARLPVAAQPKEAAVQSGAGDYLLGIKRLRRLYCNVGIGFHLQALPDGRIGGAHADTRDSLLELSPVERGVVSIFGVASRFFVAMSSKGKLYGSPFFTDECTFKEILLPNNYNAYESYKYPGMFIALSKNGKTKKGNRVSPTMKVTHFLPRL
  
Inhibitor
Name:
BDBM249396
Synonyms:
US10537571, Compound 108 | US10562888, Compound 108 | US10654836, The compound of example 108 of WO2015057938 | US10912774, Compound 108 | US11001572, Example 108 of WO2015057938 | US9434697, 108 | US9730931, Compound 108
Type:
Small organic molecule
Emp. Form.:
C29H34Cl2N8O4
Mol. Mass.:
629.537
SMILES:
CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Structure:
Search PDB for entries with ligand similarity: