Reaction Details Report a problem with these data
Target
Gonadotropin-releasing hormone II receptor
Ligand
BDBM405274
Substrate
n/a
Meas. Tech.
Receptor Activity Assay
IC50
0.570±n/a nM
Citation
 Lu, H; Sun, P; Gui, B; Dong, Q Pyrazolopyrimidone derivatives and methods of use thereof US Patent  US10633388 Publication Date 4/28/2020 
Target
Name:
Gonadotropin-releasing hormone II receptor
Synonyms:
Type II GnRH receptor | GnRH II receptor | GnRH-II-R | GNRR2_CHLAE | GNRHR2
Type:
Protein
Mol. Mass.:
41450.74
Organism:
Green monkey
Description:
Q95MH6
Residue:
379
Sequence:
MSAGNGTPWGSAVGEEAWAGSGVAVEGSELPTFSTAAKVRVGVTIVLFVSSAGGNLAVLWSVTRPQPSQLRPSPVRTLFAHLAAADLLVTFVVMPLDATWNITVQWLAGDIACRTLMFLKLMAMYSAAFLPVVIGLDRQAAVLNPLGSRSGVRKLLGAAWGLSFLLALPQLFLFHTVHRAGPVPFTQCVTKGSFKARWQETTYNLFTFCCLFLLPLIAMAICYSRIVLSVSSPQTRKGSHAPAGEFALRRSFDNRPRVCLRALRLALLILLTFILCWTPYYLLGLWYWFSPTMLTEVPPSLSHILFLFGLLNAPLDPLLYGAFTFGCRRGHQELSIDSSKEGSGRMLQQEIHALRQQEVQKTVTSRSAGETKGISITSI
  
Inhibitor
Name:
BDBM405274
Synonyms:
US10344034, Example 11 | 1-(4-(7-(2,6-difluorobenzyl)-3-((dimethylamino)methyl)-5-(6-methoxypyridazin-3-yl)-4,6-dioxo-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-d]pyrimidin-2-yl)phenyl)-3-methoxyurea | US10633388, Example 11
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
CONC(=O)Nc1ccc(cc1)-n1nc2n(Cc3c(F)cccc3F)c(=O)n(-c3ccc(OC)nn3)c(=O)c2c1CN(C)C
Structure:
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