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Target
Tyrosine-protein kinase JAK2 [808-1132]
Ligand
BDBM103727
Substrate
n/a
Meas. Tech.
Enzyme Assay
IC50
74±63 nM
Citation
 Wigerinck, P; Sabourault, NL Salts and pharmaceutical compositions thereof for the treatment of inflammatory disorders US Patent  US10708263 Publication Date 7/7/2020 
Target
Name:
Tyrosine-protein kinase JAK2 [808-1132]
Synonyms:
JAK2 | JAK2 (aa 808-1132) | JAK2_HUMAN | Tyrosine-protein kinase JAK2 JH1 (808-1132)
Type:
Protein
Mol. Mass.:
39171.39
Organism:
Homo sapiens (Human)
Description:
O60674[808-1132]
Residue:
335
Sequence:
FRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG
  
Inhibitor
Name:
BDBM103727
Synonyms:
US10112907, Example 00033 | US10206907, Compound 200 | US10708263, Compound 1 | US10766894, Compound TABLE 1.18 | US10919890, Compound 1 | US10961228, Example Filgotinib | US11000528, Cpd # 1 | US11203595, TABLE 1.18 | US11279699, Compound Filgotinib | US8563545, 1
Type:
Small organic molecule
Emp. Form.:
C21H23N5O3S
Mol. Mass.:
425.504
SMILES:
O=C(Nc1nc2cccc(-c3ccc(CN4CCS(=O)(=O)CC4)cc3)n2n1)C1CC1
Structure:
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