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Target
Interleukin-1 beta
Ligand
BDBM398217
Substrate
n/a
Meas. Tech.
IL-1beta Release Assay
IC50
<10±n/a nM
Citation
 Karra, SR Indole derivatives and their use in neurodegenerative diseases US Patent  US10676433 Publication Date 6/9/2020 
Target
Name:
Interleukin-1 beta
Synonyms:
IL1B | IL1B_HUMAN | IL1F2 | Interleukin 1-beta | Interleukin-1 beta | hIL-1beta
Type:
Cytokine
Mol. Mass.:
30734.47
Organism:
Homo sapiens (Human)
Description:
P01584
Residue:
269
Sequence:
MAEVPELASEMMAYYSGNEDDLFFEADGPKQMKCSFQDLDLCPLDGGIQLRISDHHYSKGFRQAASVVVAMDKLRKMLVPCPQTFQENDLSTFFPFIFEEEPIFFDTWDNEAYVHDAPVRSLNCTLRDSQQKSLVMSGPYELKALHLQGQDMEQQVVFSMSFVQGEESNDKIPVALGLKEKNLYLSCVLKDDKPTLQLESVDPKNYPKKKMEKRFVFNKIEINNKLEFESAQFPNWYISTSQAENMPVFLGGTKGGQDITDFTMQFVSS
  
Inhibitor
Name:
BDBM398217
Synonyms:
4-chloro-N-((3, 3-difluoro-1-hydroxycyclohexyl)methyl)-1-(pyrrolidin-2-ylmethyl)-1H-indole-3-carboxamide | US10323000, Compound 155 | US10676433, Compound 155
Type:
Small organic molecule
Emp. Form.:
C21H26ClF2N3O2
Mol. Mass.:
425.9
SMILES:
OC1(CNC(=O)c2cn(CC3CCCN3)c3cccc(Cl)c23)CCCC(F)(F)C1
Structure:
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