Reaction Details
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Small conductance calcium-activated potassium channel protein 1
Ligand
BDBM168436
Substrate
n/a
Meas. Tech.
Voltage-Clamp Assay
pH
7.3500±n/a
Temperature
298.1500±n/a K
EC50
>1.00e+5±n/a nM
Comments
extracted
Citation
PubChem, PC; Wulff, H; Coleman, N; Jenkins, DP Methods for treating seizure disorders and pain US Patent US9675591 Publication Date 6/13/2017 More Info.:
Target
Name:
Small conductance calcium-activated potassium channel protein 1
Synonyms:
Small conductance calcium-activated potassium channel protein 1 (KCa2.1) | Small conductance calcium-activated potassium channel protein 1 | KCNN1_HUMAN | KCNN1 | SK
Type:
Protein
Mol. Mass.:
60005.90
Organism:
Human
Description:
Q92952
Residue:
543
Sequence:
MNSHSYNGSVGRPLGSGPGALGRDPPDPEAGHPPQPPHSPGLQVVVAKSEPARPSPGSPRGQPQDQDDDEDDEEDEAGRQRASGKPSNVGHRLGHRRALFEKRKRLSDYALIFGMFGIVVMVTETELSWGVYTKESLYSFALKCLISLSTAILLGLVVLYHAREIQLFMVDNGADDWRIAMTCERVFLISLELAVCAIHPVPGHYRFTWTARLAFTYAPSVAEADVDVLLSIPMFLRLYLLGRVMLLHSKIFTDASSRSIGALNKITFNTRFVMKTLMTICPGTVLLVFSISSWIIAAWTVRVCERYHDKQEVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKHTRLVKKPDQARVRKHQRKFLQAIHQAQKLRSVKIEQGKLNDQANTLTDLAKTQTVMYDLVSELHAQHEELEARLATLESRLDALGASLQALPGLIAQAIRPPPPPLPPRPGPGPQDQAARSSPCRWTPVAPSDCG
Inhibitor
Name:
BDBM168436
Synonyms:
US9675591, SKA-19
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
c1cc2c(cc1SC(F)(F)F)sc(n2)N
Structure:
