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Target
Small conductance calcium-activated potassium channel protein 3
Ligand
BDBM168436
Substrate
n/a
Meas. Tech.
Voltage-Clamp Assay
pH
7.3500±n/a
Temperature
298.1500±n/a K
EC50
1.5e+4± 5e+3 nM
Comments
extracted
Citation
 PubChem, PC; Wulff, H; Coleman, N; Jenkins, DP Methods for treating seizure disorders and pain US Patent  US9675591 Publication Date 6/13/2017 
Target
Name:
Small conductance calcium-activated potassium channel protein 3
Synonyms:
Small conductance calcium-activated potassium channel protein 3 (KCa2.3) | Small conductance calcium-activated potassium channel protein 3 | KCNN3_HUMAN | KCNN3 | K3
Type:
Protein
Mol. Mass.:
82053.75
Organism:
Human
Description:
Q9UGI6
Residue:
731
Sequence:
MDTSGHFHDSGVGDLDEDPKCPCPSSGDEQQQQQQQQQQQQPPPPAPPAAPQQPLGPSLQPQPPQLQQQQQQQQQQQQQQPPHPLSQLAQLQSQPVHPGLLHSSPTAFRAPPSSNSTAILHPSSRQGSQLNLNDHLLGHSPSSTATSGPGGGSRHRQASPLVHRRDSNPFTEIAMSSCKYSGGVMKPLSRLSASRRNLIEAETEGQPLQLFSPSNPPEIVISSREDNHAHQTLLHHPNATHNHQHAGTTASSTTFPKANKRKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGLYSKDSMFSLALKCLISLSTIILLGLIIAYHTREVQLFVIDNGADDWRIAMTYERILYISLEMLVCAIHPIPGEYKFFWTARLAFSYTPSRAEADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRVCERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRIKNAAANVLRETWLIYKHTKLLKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLSDQANTLVDLSKMQNVMYDLITELNDRSEDLEKQIGSLESKLEHLTASFNSLPLLIADTLRQQQQQLLSAIIEARGVSVAVGTTHTPISDSPIGVSSTSFPTPYTSSSSC
  
Inhibitor
Name:
BDBM168436
Synonyms:
US9675591, SKA-19
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
c1cc2c(cc1SC(F)(F)F)sc(n2)N
Structure:
Search PDB for entries with ligand similarity: