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Target
Potassium voltage-gated channel subfamily B member 1
Ligand
BDBM168436
Substrate
n/a
Meas. Tech.
Voltage-Clamp Assay
pH
7.3500±n/a
Temperature
298.1500±n/a K
EC50
2.23e+4± 5.6e+3 nM
Comments
extracted
Citation
 PubChem, PC; Wulff, H; Coleman, N; Jenkins, DP Methods for treating seizure disorders and pain US Patent  US9675591 Publication Date 6/13/2017 
Target
Name:
Potassium voltage-gated channel subfamily B member 1
Synonyms:
Voltage-gated potassium channel subunit Kv2.1 | DRK1 | Potassium voltage-gated channel subfamily B member 1 | h-DRK1 | Delayed rectifier potassium channel 1 | Voltage-gated potassium channel subunit Kv2.1 (Kv2.1) | KCNB1_HUMAN | KCNB1
Type:
Protein
Mol. Mass.:
95890.66
Organism:
Human
Description:
Q14721
Residue:
858
Sequence:
MPAGMTKHGSRSTSSLPPEPMEIVRSKACSRRVRLNVGGLAHEVLWRTLDRLPRTRLGKLRDCNTHDSLLEVCDDYSLDDNEYFFDRHPGAFTSILNFYRTGRLHMMEEMCALSFSQELDYWGIDEIYLESCCQARYHQKKEQMNEELKREAETLREREGEEFDNTCCAEKRKKLWDLLEKPNSSVAAKILAIISIMFIVLSTIALSLNTLPELQSLDEFGQSTDNPQLAHVEAVCIAWFTMEYLLRFLSSPKKWKFFKGPLNAIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDDTKFKSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRREALERAKRNGSIVSMNMKDAFARSIEMMDIVVEKNGENMGKKDKVQDNHLSPNKWKWTKRTLSETSSSKSFETKEQGSPEKARSSSSPQHLNVQQLEDMYNKMAKTQSQPILNTKESAAQSKPKEELEMESIPSPVAPLPTRTEGVIDMRSMSSIDSFISCATDFPEATRFSHSPLTSLPSKTGGSTAPEVGWRGALGASGGRFVEANPSPDASQHSSFFIESPKSSMKTNNPLKLRALKVNFMEGDPSPLLPVLGMYHDPLRNRGSAAAAVAGLECATLLDKAVLSPESSIYTTASAKTPPRSPEKHTAIAFNFEAGVHQYIDADTDDEGQLLYSVDSSPPKSLPGSTSPKFSTGTRSEKNHFESSPLPTSPKFLRQNCIYSTEALTGKGPSGQEKCKLENHISPDVRVLPGGGAHGSTRDQSI
  
Inhibitor
Name:
BDBM168436
Synonyms:
US9675591, SKA-19
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
c1cc2c(cc1SC(F)(F)F)sc(n2)N
Structure:
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