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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM480668
Substrate
n/a
Meas. Tech.
Transcreener-Fluorecescence Polarization Assay
Ki
1.10±n/a nM
Citation
 Bryan, MC; Do, S; Katsumoto, T; Liang, J; Rajapaksa, NS; Kiefer, Jr., JR; Fu, L IRAK4 modulators US Patent  US10899772 Publication Date 1/26/2021 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM480668
Synonyms:
N-[6-(dimethylamino)-1-oxo- 2-[rac-(2R)-2-fluoro-3-hydroxy- 3-methyl-butyl]isoindolin-5- yl]-6-(trifluoromethyl)pyridine- 2-carboxamide | US10899772, Example 18
Type:
Small organic molecule
Emp. Form.:
C22H24F4N4O3
Mol. Mass.:
468.4446
SMILES:
CN(C)c1cc2C(=O)N(C[C@@H](F)C(C)(C)O)Cc2cc1NC(=O)c1cccc(n1)C(F)(F)F |r|
Structure:
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