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Target
Indoleamine 2,3-dioxygenase 1
Ligand
BDBM223002
Substrate
n/a
Meas. Tech.
Enzyme Assay
IC50
<100.0±n/a nM
Citation
 Gajewski, TF; Spranger, S; Leung, M Synergistic combination of immunologic inhibitors for the treatment of cancer US Patent  US10967060 Publication Date 4/6/2021 
Target
Name:
Indoleamine 2,3-dioxygenase 1
Synonyms:
I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase
Type:
Enzyme
Mol. Mass.:
45330.80
Organism:
Homo sapiens (Human)
Description:
P14902
Residue:
403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
  
Inhibitor
Name:
BDBM223002
Synonyms:
US10034939, Example 4 | US10967060, Example 4 | US11207302, Example 4 | US9320732, 4
Type:
Small organic molecule
Emp. Form.:
C13H16BrFN6O4S
Mol. Mass.:
451.271
SMILES:
CS(=O)(=O)NCCCNc1nonc1C(Nc1ccc(F)c(Br)c1)=NO |w:24.26|
Structure:
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