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Target
Indoleamine 2,3-dioxygenase 1
Ligand
BDBM223018
Substrate
n/a
Meas. Tech.
Enzyme Assay
IC50
<500±n/a nM
Citation
 Gajewski, TF; Spranger, S; Leung, M Synergistic combination of immunologic inhibitors for the treatment of cancer US Patent  US10967060 Publication Date 4/6/2021 
Target
Name:
Indoleamine 2,3-dioxygenase 1
Synonyms:
I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase
Type:
Enzyme
Mol. Mass.:
45330.80
Organism:
Homo sapiens (Human)
Description:
P14902
Residue:
403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
  
Inhibitor
Name:
BDBM223018
Synonyms:
US10034939, Example 20 | US10967060, Example 20 | US11207302, Example 20 | US9320732, 20 | US9320732, 21 | US9789094, 20
Type:
Small organic molecule
Emp. Form.:
C10H14BrN7O5S
Mol. Mass.:
424.231
SMILES:
NS(=O)(=O)NCCNc1nonc1C(NCc1cc(Br)co1)=NO |w:22.24|
Structure:
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