Reaction Details Report a problem with these data
Target
Protein arginine N-methyltransferase 5
Ligand
BDBM177922
Substrate
n/a
Meas. Tech.
PRMT5/MEP50 Enzyme Assays on Peptide Substrates
IC50
<100±n/a nM
Citation
 Duncan, KW; Chesworth, R; Boriack-Sjodin, PA; Munchhof, MJ; Jin, L PRMT5 inhibitors and uses thereof US Patent  US10980794 Publication Date 4/20/2021 
Target
Name:
Protein arginine N-methyltransferase 5
Synonyms:
Human Flag-PRMT5/6His-MeP50 protein | PRMT5/MeP50
Type:
Protein
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Protein arginine N-methyltransferase 5
Synonyms:
PRMT5 | IBP72 | SKB1 | Flag-PRMT5 | Protein arginine N-methyltransferase 5 (PRMT5)(2-637) | Protein arginine N-methyltransferase 5 [2-637] | Protein arginine N-methyltransferase 5 (Flag-PRMT5) | HRMT1L5 | JBP1 | ANM5_HUMAN
Type:
Protein
Mol. Mass.:
72548.80
Organism:
Human
Description:
Full-length PRMT5 with FLAG tag fused directly to Ala 2 (MDYKDDDDK removed)
Residue:
636
Sequence:
AAMAVGGAGGSRVSSGRDLNCVPEIADTLGAVAKQGFDFLCMPVFHPRFKREFIQEPAKNRPGPQTRSDLLLSGRDWNTLIVGKLSPWIRPDSKVEKIRRNSEAAMLQELNFGAYLGLPAFLLPLNQEDNTNLARVLTNHIHTGHHSSMFWMRVPLVAPEDLRDDIIENAPTTHTEEYSGEEKTWMWWHNFRTLCDYSKRIAVALEIGADLPSNHVIDRWLGEPIKAAILPTSIFLTNKKGFPVLSKMHQRLIFRLLKLEVQFIITGTNHHSEKEFCSYLQYLEYLSQNRPPPNAYELFAKGYEDYLQSPLQPLMDNLESQTYEVFEKDPIKYSQYQQAIYKCLLDRVPEEEKDTNVQVLMVLGAGRGPLVNASLRAAKQADRRIKLYAVEKNPNAVVTLENWQFEEWGSQVTVVSSDMREWVAPEKADIIVSELLGSFADNELSPECLDGAQHFLKDDGVSIPGEYTSFLAPISSSKLYNEVRACREKDRDPEAQFEMPYVVRLHNFHQLSAPQPCFTFSHPNRDPMIDNNRYCTLEFPVEVNTVLHGFAGYFETVLYQDITLSIRPETHSPGMFSWFPILFPIKQPITVREGQTICVRFWRCSNSKKVWYEWAVTAPVCSAIHNPTGRSYTIGL
  
Component 2
Name:
Protein arginine N-methyltransferase 5
Synonyms:
Methylosome protein 50 (6His-MeP50) | 6His-MEP50 | ANM5_HUMAN | PRMT5 | HRMT1L5 | IBP72 | JBP1 | SKB1
Type:
Protein
Mol. Mass.:
37539.24
Organism:
Human
Description:
Full-length MeP50 with His tag fused directly to Arg 2 of MEP50
Residue:
348
Sequence:
MHHHHHHRKETPPPLVPPAAREWNLPPNAPACMERQLEAARYRSDGALLLGASSLSGRCWAGSLWLFKDPCAAPNEGFCSAGVQTEAGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQVVHHVVPTEPLPAPGPASVTE
  
Inhibitor
Name:
BDBM177922
Synonyms:
US9675614, 166 | US10307413, Compound 337 | US10391089, Compound 166 | US10980794, Cmpd No 166 | US11591326, Compound C1
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: