Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM494222
Substrate
n/a
Meas. Tech.
Biological Assay
Ki
1.70±n/a nM
Citation
 Bryan, MCGobbi, AKiefer, Jr., JRKolesnikov, AOlivero, AGDrobnick, JLiang, JRajapaksa, NNdubaku, CFeng, J Pyrazolo[1,5a]pyrimidine derivatives as IRAK4 modulators US Patent  US10988478 Publication Date 4/27/2021 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM494222
Synonyms:
6-Chloro-N-[2-[(2R)-2- fluoro-3-hydroxy-3-methyl- butyl]-6-morpholino-1-oxo- isoindolin-5- yl]pyrazolo[1,5- a]pyrimidine-3-carboxamide | US10988478, Example 271
Type:
Small organic molecule
Emp. Form.:
C24H26ClFN6O4
Mol. Mass.:
516.952
SMILES:
CC(C)(O)[C@H](F)CN1Cc2cc(NC(=O)c3cnn4cc(Cl)cnc34)c(cc2C1=O)N1CCOCC1 |r|
Structure:
Search PDB for entries with ligand similarity: