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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM494453
Substrate
n/a
Meas. Tech.
Biological Assay
Ki
1.10±n/a nM
Citation
 Bryan, MC; Gobbi, A; Kiefer, Jr., JR; Kolesnikov, A; Olivero, AG; Drobnick, J; Liang, J; Rajapaksa, N; Ndubaku, C; Feng, J Pyrazolo[1,5a]pyrimidine derivatives as IRAK4 modulators US Patent  US10988478 Publication Date 4/27/2021 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM494453
Synonyms:
N-(6-(4-((1H-imidazol-4- yl)-2,2-dimethyl-2,3- yl)methyl)piperazin-1- dihydrobenzofuran-5- yl)pyrazolo[1,5- a]pyrimidine-3- carboxamide | US10988478, Example 509
Type:
Small organic molecule
Emp. Form.:
C25H28N8O2
Mol. Mass.:
472.5422
SMILES:
CC1(C)Cc2cc(NC(=O)c3cnn4cccnc34)c(cc2O1)N1CCN(Cc2c[nH]cn2)CC1
Structure:
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