Reaction Details Report a problem with these data
Target
Nuclear receptor ROR-gamma
Ligand
BDBM504173
Substrate
n/a
Meas. Tech.
Transcreener-Fluorecescence Polarization Assay
Ki
2.30±n/a nM
Citation
 Bryan, MC; Do, S; Drobnick, J; Gobbi, A; Katsumoto, T; Kiefer, Jr., JR; Liang, J; Rajapaksa, NS; Chen, Y; Fu, L; Lai, KW; Liu, Z; Wai, J; Wang, F Pyrazolo[ 1,5a]pyrimidine derivatives as IRAK4 modulators US Patent  US11034698 Publication Date 6/15/2021 
Target
Name:
Nuclear receptor ROR-gamma
Synonyms:
NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
58218.40
Organism:
Homo sapiens (Human)
Description:
P51449
Residue:
518
Sequence:
MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
  
Inhibitor
Name:
BDBM504173
Synonyms:
N-(6-(4-((4-Chloro-1H- imidazol-5-yl)methyl)piperazin- 1-yl)-2,2-dimethyl-2,3- dihydrobenzofuran-5- yl)pyrazolo[1,5-a)pyrimidine-3 carboxamide | US11034698, Example 10
Type:
Small organic molecule
Emp. Form.:
C25H27ClN8O2
Mol. Mass.:
506.987
SMILES:
CC1(C)Cc2cc(NC(=O)c3cnn4cccnc34)c(cc2O1)N1CCN(Cc2[nH]cnc2Cl)CC1
Structure:
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