Compile Data Set for Download or QSAR
Report error Found 5 Enz. Inhib. hit(s) for PDB: 4DST
TargetGTPase KRas(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50436053(CHEMBL2396992)
Affinity DataEC50:  1.58E+4nMAssay Description:Inhibition of KRas activation in HEK 293T-REx Flp-In cells harboring Venus-RBD-CRD/mCherry-CAAX assessed as reduction in Venus-RBD-CRD recruitment to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetGTPase KRas(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50436053(CHEMBL2396992)
Affinity DataKd:  1.10E+6nMAssay Description:Binding affinity to KRAS (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetGTPase KRas(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50436053(CHEMBL2396992)
Affinity DataIC50: 1.55E+5nMAssay Description:Inhibition of full-length human KRas4B (amino acids 1 to 188)-SOS interaction assessed as inhibition of SOS-mediated nucleotide release activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetGTPase KRas(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50436053(CHEMBL2396992)
Affinity DataIC50: 1.55E+5nMAssay Description:Inhibition of KRas (unknown origin) by nucleotide release assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2016
Entry Details Article
PubMed
TargetGTPase KRas(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50436053(CHEMBL2396992)
Affinity DataIC50: 3.42E+5nMAssay Description:Inhibition of full-length human KRas4B (amino acids 1 to 188)-SOS interaction assessed as inhibition of nucleotide exchange activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed