Compile Data Set for Download or QSAR
Report error Found 5 Enz. Inhib. hit(s) for PDB: 4ITH
LigandPNGBDBM36372(CID11288934 | (5R)-5-[(7-chloro-1H-indol-3-yl)meth...)
Affinity DataEC50:  18nMpH: 7.3 T: 2°CAssay Description:In vitro kinase assay using RIP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM36372(CID11288934 | (5R)-5-[(7-chloro-1H-indol-3-yl)meth...)
Affinity DataIC50: 200nMAssay Description:Inhibition of human RIP1 (1 to 375 residues) after 4 hrs by ADP-Glo reagent based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM36372(CID11288934 | (5R)-5-[(7-chloro-1H-indol-3-yl)meth...)
Affinity DataIC50: 320nMAssay Description:Inhibition of RIPK1 kinase domain (unknown origin) (1 to 312 domain) incubated for 30 mins in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM36372(CID11288934 | (5R)-5-[(7-chloro-1H-indol-3-yl)meth...)
Affinity DataIC50: 320nMAssay Description:Inhibition of human RIP1 in human U937 cells assessed as inhibition of TNF/zVAD.fmk induced necroptosis after 24 hrs by Cell titer-Glo luminescence a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM36372(CID11288934 | (5R)-5-[(7-chloro-1H-indol-3-yl)meth...)
Affinity DataIC50: 630nMAssay Description:Inhibition of Flag-tagged human RIP1 (1 to 324 residues) after 30 mins by ADP-Glo reagent based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)