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Found 43 for UniProtKB: P14270
LigandPNGBDBM50110039(1-[2-(3-Cyclopropylmethoxy-4-methoxy-phenyl)-propy...)
Affinity DataKi:  3.5nMAssay Description:Displacement of [3H]rolipram from rat forebrain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataKi:  11nMAssay Description:Inhibition of [3H]rolipram binding to Phosphodiesterase 4 of rat forebrain membraneMore data for this Ligand-Target Pair
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataKi:  26nMAssay Description:Inhibition of [3H]rolipram binding to Phosphodiesterase 4 of rat forebrain membraneMore data for this Ligand-Target Pair
LigandPNGBDBM50451480(CHEMBL2093042)
Affinity DataKi:  63nMAssay Description:Displacement of [3H]rolipram from rat forebrain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50110030(1-{2-[3-(Indan-2-yloxy)-4-methoxy-phenyl]-propyl}-...)
Affinity DataKi:  180nMAssay Description:Displacement of [3H]rolipram from rat forebrain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50366802(CHEMBL1788264)
Affinity DataKi:  220nMAssay Description:Displacement of [3H]rolipram from rat forebrain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataIC50:  6nMAssay Description:Displacement of [3H]rolipram from high affinity binding site (HARBS) in rat brain membrane.More data for this Ligand-Target Pair
LigandPNGBDBM50218545(Nitraquazone)
Affinity DataIC50:  10nMAssay Description:Displacement of [3H]rolipram from high affinity binding site (HARBS) in rat brain membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50072197(2-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-2-ethyl-6...)
Affinity DataIC50:  15nMAssay Description:Evaluated for the inhibition of [3H]rolipram binding to membrane-bound PDE4.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50072195(2-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-2-ethoxy-...)
Affinity DataIC50:  43nMAssay Description:Evaluated for the inhibition of [3H]rolipram binding to membrane-bound PDE4.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50072194(2-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-2-butyl-6...)
Affinity DataIC50:  50nMAssay Description:Inhibition of [3H]-rolipram binding to membrane-bound PDE4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50072200(3-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-7-(2-hydr...)
Affinity DataIC50:  145nMAssay Description:Evaluated for the inhibition of [3H]rolipram binding to membrane-bound PDE4.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50072209(3-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-7-(2-hydr...)
Affinity DataIC50:  200nMAssay Description:Evaluated for the inhibition of [3H]rolipram binding to membrane-bound PDE4.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50072199(2-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-2,6-dimet...)
Affinity DataIC50:  210nMAssay Description:Evaluated for the inhibition of [3H]rolipram binding to membrane-bound PDE4.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14769(6-(3,4-Dimethoxy-phenyl)-4,5-dimethyl-4,5-dihydro-...)
Affinity DataIC50:  210nMAssay Description:Inhibitory concentration against phosphodiesterase 4 (PDE4) from rat kidneyMore data for this Ligand-Target Pair
LigandPNGBDBM50212893(CHEMBL298529)
Affinity DataIC50:  580nMAssay Description:Inhibition of [3H]rolipram binding to rat cortexMore data for this Ligand-Target Pair
In DepthDetails
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataIC50:  740nMAssay Description:Inhibitory concentration against phosphodiesterase 4 (PDE4) from rat kidneyMore data for this Ligand-Target Pair
LigandPNGBDBM50218550(CHEMBL327581)
Affinity DataIC50:  900nMAssay Description:Displacement of [3H]rolipram from high affinity binding site (HARBS) in rat brain membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50218544(CHEMBL88527)
Affinity DataIC50:  1.00E+3nMAssay Description:Displacement of [3H]rolipram from high affinity binding site (HARBS) in rat brain membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50146545(2-[6-(3,4-Dimethoxy-benzylamino)-7-ethyl-7H-purin-...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibitory concentration against phosphodiesterase 4 (PDE4) from rat kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataIC50:  1.12E+3nMAssay Description:Inhibition of Phosphodiesterase 4 from rat liverMore data for this Ligand-Target Pair
LigandPNGBDBM50218418(CHEMBL90189)
Affinity DataIC50:  1.20E+3nMAssay Description:Displacement of [3H]rolipram from high affinity binding site (HARBS) in rat brain membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50218534(CHEMBL314537)
Affinity DataIC50:  1.50E+3nMAssay Description:Displacement of [3H]rolipram from high affinity binding site (HARBS) in rat brain membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50218419(CHEMBL91952)
Affinity DataIC50:  2.00E+3nMAssay Description:Displacement of [3H]rolipram from high affinity binding site (HARBS) in rat brain membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50218416(CHEMBL316449)
Affinity DataIC50:  2.00E+3nMAssay Description:Displacement of [3H]rolipram from high affinity binding site (HARBS) in rat brain membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50116711(3,7-Dihydroxy-2-(4-hydroxy-phenyl)-5-methoxy-8-(3-...)
Affinity DataIC50:  2.55E+3nMAssay Description:Inhibition of Phosphodiesterase 4 from rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14390(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)
Affinity DataIC50:  4.60E+3nMAssay Description:Inhibitory concentration against phosphodiesterase 4 (PDE4) from rat kidneyMore data for this Ligand-Target Pair
LigandPNGBDBM50218417(CHEMBL90335)
Affinity DataIC50:  4.70E+3nMAssay Description:Displacement of [3H]rolipram from high affinity binding site (HARBS) in rat brain membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50218537(CHEMBL91007)
Affinity DataIC50:  5.00E+3nMAssay Description:Displacement of [3H]rolipram from high affinity binding site (HARBS) in rat brain membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50218420(CHEMBL88442)
Affinity DataIC50:  5.60E+3nMAssay Description:Displacement of [3H]rolipram from high affinity binding site (HARBS) in rat brain membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50218540(CHEMBL314088)
Affinity DataIC50:  6.00E+3nMAssay Description:Displacement of [3H]rolipram from high affinity binding site (HARBS) in rat brain membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50366788(KURARINOL)
Affinity DataIC50:  6.59E+3nMAssay Description:Inhibition of Phosphodiesterase 4 from rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50366787(KURAIDIN)
Affinity DataIC50:  8.27E+3nMAssay Description:Inhibition of Phosphodiesterase 5 from rat diaphragmMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50421642(CHEMBL516604)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory concentration against phosphodiesterase 4 (PDE4) from rat kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM15297(CHEMBL34431 | Cilostamide | N-Cyclohexyl-N-methyl-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory concentration against phosphodiesterase 4 (PDE4) from rat kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50218422(CHEMBL90920)
Affinity DataIC50:  1.40E+4nMAssay Description:Displacement of [3H]rolipram from high affinity binding site (HARBS) in rat brain membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50116713((2R,3R)-2-(2,4-Dihydroxy-phenyl)-3,7-dihydroxy-8-(...)
Affinity DataIC50:  1.87E+4nMAssay Description:Inhibition of Phosphodiesterase 4 from rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50116710((2R,3S)-2-(2,4-Dihydroxy-phenyl)-3,7-dihydroxy-8-(...)
Affinity DataIC50:  3.38E+4nMAssay Description:Inhibition of Phosphodiesterase 4 from rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50218539(CHEMBL314089)
Affinity DataIC50:  3.50E+4nMAssay Description:Displacement of [3H]rolipram from high affinity binding site (HARBS) in rat brain membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50218538(CHEMBL92004)
Affinity DataIC50:  5.00E+4nMAssay Description:Displacement of [3H]rolipram from high affinity binding site (HARBS) in rat brain membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Rattus norvegicus)
Inserm U352

Curated by ChEMBL
LigandPNGBDBM50474148(CHEMBL1160096)
Affinity DataEC50:  2.35E+4nMAssay Description:Activation of PDE4D3 (phosphodiesterase).More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Rattus norvegicus)
Inserm U352

Curated by ChEMBL
LigandPNGBDBM50474146(CHEMBL1160098)
Affinity DataEC50:  2.35E+4nMAssay Description:Activation of PDE4D3 (phosphodiesterase).More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Rattus norvegicus)
Inserm U352

Curated by ChEMBL
LigandPNGBDBM50474147(CHEMBL1160097)
Affinity DataEC50:  2.42E+4nMAssay Description:Activation of PDE4D3 (phosphodiesterase).More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed