Compile Data Set for Download or QSAR
maximum 50k data
Found 67 of affinity data for UniProtKB/TrEMBL: P17712
TargetHexokinase-4(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50444409(CHEMBL3091581)
Affinity DataIC50:  1.70E+3nMAssay Description:Activation of glucokinase in Wistar rat hepatocytes assessed as nuclear to cytosolic translocation of protein by immunofluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-4(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50161668(1-Cyclopentylmethyl-1-(4-methanesulfonyl-phenyl)-3...)
Affinity DataEC50:  1.60E+4nMAssay Description:Effective concentration for glucokinase activation with 5 mM glucoseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-4(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50161669(1-Cyclopentylmethyl-1-(6-methoxy-pyridin-3-yl)-3-(...)
Affinity DataEC50:  2.91E+4nMAssay Description:Effective concentration for glucokinase activation with 5 mM glucoseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-4(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50161670(3-[3-(5-Chloro-thiazol-2-yl)-1-cyclopentylmethyl-u...)
Affinity DataEC50:  1.00E+3nMAssay Description:Effective concentration for glucokinase activation with 5 mM glucoseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-4(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50161671(3-(5-Bromo-thiazol-2-yl)-1-(4-methanesulfonyl-phen...)
Affinity DataEC50:  2.41E+4nMAssay Description:Effective concentration for glucokinase activation with 5 mM glucoseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-4(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50161672(3-(5-Bromo-thiazol-2-yl)-1-cyclopentylmethyl-1-(6-...)
Affinity DataEC50:  2.00E+3nMAssay Description:Effective concentration for glucokinase activation with 5 mM glucoseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-4(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50161673(1-Cyclopentylmethyl-1-(4-methanesulfonyl-phenyl)-3...)
Affinity DataEC50:  3.42E+4nMAssay Description:Effective concentration for glucokinase activation with 5 mM glucoseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-4(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50161674(3-Cyclopentyl-2-(4-methanesulfonyl-phenyl)-N-thiaz...)
Affinity DataEC50:  1.00E+3nMAssay Description:Effective concentration for glucokinase activation with 15 mM glucoseMore data for this Ligand-Target Pair
TargetHexokinase-4(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50161676(1-Cyclopentylmethyl-1-(3,4-difluoro-phenyl)-3-thia...)
Affinity DataEC50:  1.63E+4nMAssay Description:Effective concentration for glucokinase activation with 5 mM glucoseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-4(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50161677(4-[3-(5-Chloro-thiazol-2-yl)-1-cyclopentylmethyl-u...)
Affinity DataEC50:  1.80E+3nMAssay Description:Effective concentration for glucokinase activation with 5 mM glucoseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-4(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50161675(3-(5-Chloro-thiazol-2-yl)-1-(4-methanesulfonyl-phe...)
Affinity DataEC50:  6.80E+3nMAssay Description:Effective concentration for glucokinase activation with 5 mM glucoseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-4(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50161680(3-(5-Chloro-thiazol-2-yl)-1-furan-2-ylmethyl-1-(4-...)
Affinity DataEC50:  1.15E+4nMAssay Description:Effective concentration for glucokinase activation with 5 mM glucoseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-4(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50161681(3-(5-Chloro-thiazol-2-yl)-1-(6-cyano-pyridin-3-yl)...)
Affinity DataEC50:  7.70E+3nMAssay Description:Effective concentration for glucokinase activation with 5 mM glucoseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-4(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50161682(3-(5-Chloro-thiazol-2-yl)-1-cyclopentylmethyl-1-(3...)
Affinity DataEC50:  1.40E+3nMAssay Description:Effective concentration for glucokinase activation with 5 mM glucoseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-4(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50161678(3-(5-Chloro-thiazol-2-yl)-1-cyclopentylmethyl-1-(6...)
Affinity DataEC50:  2.70E+3nMAssay Description:Effective concentration for glucokinase activation with 5 mM glucoseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-4(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50161679(3-(5-Chloro-thiazol-2-yl)-1-(4-cyano-phenyl)-1-cyc...)
Affinity DataEC50:  2.40E+3nMAssay Description:Effective concentration for glucokinase activation with 5 mM glucoseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-4(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50161684(1-Cyclopentylmethyl-3-(6-methanesulfonyl-benzothia...)
Affinity DataEC50:  3.29E+4nMAssay Description:Effective concentration for glucokinase activation with 5 mM glucoseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-4(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50161685(1-Cyclopentylmethyl-1-(6-methoxy-pyridin-3-yl)-3-t...)
Affinity DataEC50:  1.92E+4nMAssay Description:Effective concentration for glucokinase activation with 5 mM glucoseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-4(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50161683(3-(5-Chloro-thiazol-2-yl)-1-(4-methanesulfonyl-phe...)
Affinity DataEC50:  4.90E+3nMAssay Description:Effective concentration for glucokinase activation with 5 mM glucoseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-4(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50161674(3-Cyclopentyl-2-(4-methanesulfonyl-phenyl)-N-thiaz...)
Affinity DataEC50:  2.20E+3nMAssay Description:Effective concentration for glucokinase activation with 5 mM glucoseMore data for this Ligand-Target Pair
TargetHexokinase-4(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50161686(3-(5-Chloro-thiazol-2-yl)-1-cyclopentylmethyl-1-(4...)
Affinity DataEC50:  1.30E+3nMAssay Description:Effective concentration for glucokinase activation with 5 mM glucoseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-4(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50161687(3-(5-Chloro-thiazol-2-yl)-1-cyclopentylmethyl-1-(4...)
Affinity DataEC50:  1.50E+3nMAssay Description:Effective concentration for glucokinase activation with 5 mM glucoseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-4(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50161688(3-(5-Chloro-thiazol-2-yl)-1-(4-methanesulfonyl-phe...)
Affinity DataEC50:  6.60E+3nMAssay Description:Effective concentration for glucokinase activation with 5 mM glucoseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-4(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50161689(3-(5-Chloro-thiazol-2-yl)-1-(4-methanesulfonyl-phe...)
Affinity DataEC50:  2.19E+4nMAssay Description:Effective concentration for glucokinase activation with 5 mM glucoseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-4(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50161690(3-(5-Chloro-thiazol-2-yl)-1-cyclopentylmethyl-1-(3...)
Affinity DataEC50:  2.60E+3nMAssay Description:Effective concentration for glucokinase activation with 5 mM glucoseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-4(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50161691(CHEMBL180172 | N-{3-[3-(5-Chloro-thiazol-2-yl)-1-c...)
Affinity DataEC50:  300nMAssay Description:Effective concentration for glucokinase activation with 5 mM glucoseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-4(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50161694(3-(5-Bromo-thiazol-2-yl)-1-(4-methanesulfonyl-phen...)
Affinity DataEC50:  6.50E+3nMAssay Description:Effective concentration for glucokinase activation with 5 mM glucoseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-4(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50161693(3-(5-Chloro-thiazol-2-yl)-1-(4-methanesulfonyl-phe...)
Affinity DataEC50:  2.16E+4nMAssay Description:Effective concentration for glucokinase activation with 5 mM glucoseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-4(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50161668(1-Cyclopentylmethyl-1-(4-methanesulfonyl-phenyl)-3...)
Affinity DataEC50:  9.70E+3nMAssay Description:Effective concentration for glucokinase activation with 15 mM glucoseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-4(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50161695(1-(4-Bromo-3-fluoro-phenyl)-3-(5-chloro-thiazol-2-...)
Affinity DataEC50:  700nMAssay Description:Effective concentration for glucokinase activation with 5 mM glucoseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-4(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50161692(1-(3-Chloro-4-methyl-phenyl)-3-(5-chloro-thiazol-2...)
Affinity DataEC50:  400nMAssay Description:Effective concentration for glucokinase activation with 5 mM glucoseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-4(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50321004((R)-2-(4-(Cyclopropylsulfonyl)phenyl)-N-(4-isoprop...)
Affinity DataEC50:  26nMAssay Description:Induction of glucokinase-mediated 2-deoxy-D-[3H]glucose uptake in Sprague-Dawley rat hepatocytes after 4 hrs by liquid scintillation countinglMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-4(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50394681(CHEMBL2165620)
Affinity DataEC50:  6.90E+3nMAssay Description:Activation of glucokinase in rat INS-1 cells assessed as stimulation of glucose-induced insulin secretionMore data for this Ligand-Target Pair
TargetHexokinase-4(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50394682(CHEMBL2165619)
Affinity DataEC50:  153nMAssay Description:Activation of glucokinase in rat INS-1 cells assessed as stimulation of glucose-induced insulin secretionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-4(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50394684(CHEMBL2165615)
Affinity DataEC50:  900nMAssay Description:Induction of glucokinase translocation from nucleus to cytoplasm in cryopreserved rat hepatocytes after 1 hr by Hoechst staining-based fluorescence m...More data for this Ligand-Target Pair
TargetHexokinase-4(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50394681(CHEMBL2165620)
Affinity DataEC50:  190nMAssay Description:Induction of glucokinase translocation from nucleus to cytoplasm in cryopreserved rat hepatocytes after 1 hr by Hoechst staining-based fluorescence m...More data for this Ligand-Target Pair
TargetHexokinase-4(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50444409(CHEMBL3091581)
Affinity DataEC50:  1.74E+5nMAssay Description:Activation of glucokinase in rat INS-1 cells assessed as glucose-stimulated insulin secretionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-4(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50444410(CHEMBL3091580)
Affinity DataEC50:  2.60E+4nMAssay Description:Activation of glucokinase in rat INS-1 cells assessed as glucose-stimulated insulin secretionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-4(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50401849(CHEMBL2204663)
Affinity DataEC50:  350nMAssay Description:Activation of recombinant rat glucokinase assessed measuring rate of glucose 6-phosphate formation using G6PDH/NADP couplingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-4(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50239048(CHEMBL4067028)
Affinity DataEC50:  0.900nMAssay Description:Activation of glucokinase in rat INS-1 cells assessed as increase in D-2-deoxyglucose-6-phosphate level in presence of D-2-deoxyglucose by HILIC LC-M...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-4(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50239048(CHEMBL4067028)
Affinity DataEC50:  0.900nMAssay Description:Activation of glucokinase in rat INS-1 cells assessed as increase in D-2-deoxyglucose-6-phosphate level in presence of D-2-deoxyglucose by HILIC LC-M...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-4(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50239040(CHEMBL4086771)
Affinity DataEC50:  21nMAssay Description:Activation of glucokinase in rat INS-1 cells assessed as increase in D-2-deoxyglucose-6-phosphate level in presence of D-2-deoxyglucose by HILIC LC-M...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-4(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50239040(CHEMBL4086771)
Affinity DataEC50:  21nMAssay Description:Activation of glucokinase in rat INS-1 cells assessed as increase in D-2-deoxyglucose-6-phosphate level in presence of D-2-deoxyglucose by HILIC LC-M...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-4(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50239047(CHEMBL4078915)
Affinity DataEC50:  7.20nMAssay Description:Activation of glucokinase in rat INS-1 cells assessed as increase in D-2-deoxyglucose-6-phosphate level in presence of D-2-deoxyglucose by HILIC LC-M...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-4(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50239046(CHEMBL4068048)
Affinity DataEC50:  3.90nMAssay Description:Activation of glucokinase in rat INS-1 cells assessed as increase in D-2-deoxyglucose-6-phosphate level in presence of D-2-deoxyglucose by HILIC LC-M...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-4(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50239046(CHEMBL4068048)
Affinity DataEC50:  3.90nMAssay Description:Activation of glucokinase in rat INS-1 cells assessed as increase in D-2-deoxyglucose-6-phosphate level in presence of D-2-deoxyglucose by HILIC LC-M...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-4(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50239045(CHEMBL4083339)
Affinity DataEC50:  2.5nMAssay Description:Activation of glucokinase in rat INS-1 cells assessed as increase in D-2-deoxyglucose-6-phosphate level in presence of D-2-deoxyglucose by HILIC LC-M...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-4(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50239044(CHEMBL4104680)
Affinity DataEC50:  7.80nMAssay Description:Activation of glucokinase in rat INS-1 cells assessed as increase in D-2-deoxyglucose-6-phosphate level in presence of D-2-deoxyglucose by HILIC LC-M...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-4(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50239049(CHEMBL4086782)
Affinity DataEC50:  1.70nMAssay Description:Activation of glucokinase in rat INS-1 cells assessed as increase in D-2-deoxyglucose-6-phosphate level in presence of D-2-deoxyglucose by HILIC LC-M...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-4(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50239043(CHEMBL4067037)
Affinity DataEC50:  22nMAssay Description:Activation of glucokinase in rat INS-1 cells assessed as increase in D-2-deoxyglucose-6-phosphate level in presence of D-2-deoxyglucose by HILIC LC-M...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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