BDBM50448780 CHEMBL3128050

SMILES Cc1nc2ccc(cc2n1-c1ncnc(N)n1)C#CC1(O)CCCCC1

InChI Key InChIKey=RSIUBEYNBJJYTG-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50448780   

TargetSerine/threonine-protein kinase PAK 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50448780(CHEMBL3128050)
Affinity DataKi:  68nMAssay Description:Binding affinity to N-terminal GST-tagged recombinant human PAK4 kinase domain expressed in Escherichia coli using KKRNRRLSVA as substrate preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50448780(CHEMBL3128050)
Affinity DataKi:  68nMAssay Description:Inhibition of human recombinant PAK4 assessed as inhibition constant incubated for 10 mins by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50448780(CHEMBL3128050)
Affinity DataKi:  68nMAssay Description:Inhibition of human recombinant PAK4 using KKRNRRLSVA as substrate assessed as inhibition constant preincubated with compound for 10 mins followed by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase PAK 1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50448780(CHEMBL3128050)
Affinity DataKi: >4.50E+3nMAssay Description:Binding affinity to N-terminal GST-His-tagged recombinant human PAK1 kinase domain expressed in Escherichia coli BL21 using KKRNRRLSVA as sustrate pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase N1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50448780(CHEMBL3128050)
Affinity DataKi: >4.50E+3nMAssay Description:Inhibition of human recombinant PAK1 using KKRNRRLSVA as substrate assessed as inhibition constant preincubated with compound for 10 mins followed by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed