BDBM101536 CHEMBL3128043::US8530494, 203::US8530652, 114::US8530652, 63
SMILES CN(C)C[C@@H](NC(=O)N1Cc2c(Nc3nc(C)nc4ccsc34)[nH]nc2C1(C)C)c1ccccc1
InChI Key InChIKey=AYCPARAPKDAOEN-LJQANCHMSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 20 hits for monomerid = 101536
Affinity DataKi: 15nMAssay Description:Binding affinity to N-terminal GST-tagged recombinant human PAK4 kinase domain expressed in Escherichia coli using KKRNRRLSVA as substrate preincubat...More data for this Ligand-Target Pair
Affinity DataKi: 15nMAssay Description:Binding affinity to N-terminal His-6-tagged recombinant human PAK1 using peptide substrateMore data for this Ligand-Target Pair
Affinity DataKi: 20nM EC50: <3.90nMAssay Description:The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...More data for this Ligand-Target Pair
Affinity DataKi: 36nMAssay Description:Binding affinity to N-terminal His-6-tagged recombinant human PAK4 using peptide substrateMore data for this Ligand-Target Pair
Affinity DataKi: 36nMAssay Description:Binding affinity to N-terminal GST-His-tagged recombinant human PAK1 kinase domain expressed in Escherichia coli BL21 using KKRNRRLSVA as sustrate pr...More data for this Ligand-Target Pair
Affinity DataIC50: 24nMAssay Description:Inhibition of PAK4 (unknown origin) using substrate S2 after 60 mins by HTRF assayMore data for this Ligand-Target Pair
TargetCDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7(Homo sapiens (Human))
Lebanese American University
Curated by ChEMBL
Lebanese American University
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of CDK7/cyclin H/MNAT1 (unknown origin) pre incubated up to 60 mins followed by substrate and ATP additionMore data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of PAK1 (unknown origin) using Syntide2 peptide as substrate by pyruvate kinase/LDH dehydrogenase coupled assayMore data for this Ligand-Target Pair
Affinity DataIC50: 36nMAssay Description:Inhibition of PAK1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of PAK4 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 52nMAssay Description:Inhibition of full length recombinant human N-terminal GST/His6-tagged PAK1 expressed in sf9 insect cells using tetra LRRWSLG as substrate preincubat...More data for this Ligand-Target Pair
Affinity DataIC50: 38nMAssay Description:Inhibition of full length recombinant human N-terminal GST/His6-tagged PAK4 expressed in baculovirus infected sf9 insect cells using tetra LRRWSLG as...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 4.21E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Affinity DataIC50: 39nMAssay Description:Inhibition of PAK1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of PAK4 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 24nMAssay Description:Inhibition of PAK4 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Inhibition of peptide substrate phosphorylation by epidermal growth factor receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged PAK4 expressed in bacterial expression system by pyruvate kinase/LDH enzyme coupled assayMore data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of PAK1 (unknown origin) using S2 peptide as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Inhibition of full length human PAK4 using substrate S2 after 60 mins by HTRF assayMore data for this Ligand-Target Pair