BDBM11242 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide::med.21724, Compound 76::niclosamide

SMILES Oc1ccc(Cl)cc1C(=O)Nc1ccc(cc1Cl)[N+]([O-])=O

InChI Key InChIKey=RJMUSRYZPJIFPJ-UHFFFAOYSA-N

Data  28 IC50

Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 28 hits for monomerid = 11242   

TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
National Taiwan University

LigandPNGBDBM11242(5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...)
Show SMILES Oc1ccc(Cl)cc1C(=O)Nc1ccc(cc1Cl)[N+]([O-])=O
Show InChI InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)
Affinity DataIC50: 5.00E+4nMpH: 7.0 T: 2°CAssay Description:The effects of compound on enzyme activity were measured by using a fluorogenic peptide cleavage assay. Enhanced fluorescence caused by cleavage of t...More data for this Ligand-Target Pair
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
The First Affiliated Hospital of Wenzhou Medical University

Curated by ChEMBL
LigandPNGBDBM11242(5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...)
Show SMILES Oc1ccc(Cl)cc1C(=O)Nc1ccc(cc1Cl)[N+]([O-])=O
Show InChI InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)
Affinity DataIC50: 210nMAssay Description:Inhibition of STAT3 phosphorylation in human MDA-MB-231 cells by sandwich ELISAMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM11242(5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...)
Show SMILES Oc1ccc(Cl)cc1C(=O)Nc1ccc(cc1Cl)[N+]([O-])=O
Show InChI InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of JAK2More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM11242(5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...)
Show SMILES Oc1ccc(Cl)cc1C(=O)Nc1ccc(cc1Cl)[N+]([O-])=O
Show InChI InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Src kinaseMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM11242(5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...)
Show SMILES Oc1ccc(Cl)cc1C(=O)Nc1ccc(cc1Cl)[N+]([O-])=O
Show InChI InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of Flt3 after 60 mins by radiometric assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM11242(5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...)
Show SMILES Oc1ccc(Cl)cc1C(=O)Nc1ccc(cc1Cl)[N+]([O-])=O
Show InChI InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of JAK2 after 60 mins by radiometric assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM11242(5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...)
Show SMILES Oc1ccc(Cl)cc1C(=O)Nc1ccc(cc1Cl)[N+]([O-])=O
Show InChI InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of JNK1 after 60 mins by radiometric assayMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM11242(5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...)
Show SMILES Oc1ccc(Cl)cc1C(=O)Nc1ccc(cc1Cl)[N+]([O-])=O
Show InChI InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of PDGFR-beta after 60 mins by radiometric assayMore data for this Ligand-Target Pair
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
The First Affiliated Hospital of Wenzhou Medical University

Curated by ChEMBL
LigandPNGBDBM11242(5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...)
Show SMILES Oc1ccc(Cl)cc1C(=O)Nc1ccc(cc1Cl)[N+]([O-])=O
Show InChI InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)
Affinity DataIC50: 250nMAssay Description:Inhibition of STAT3 in human HeLa cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM11242(5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...)
Show SMILES Oc1ccc(Cl)cc1C(=O)Nc1ccc(cc1Cl)[N+]([O-])=O
Show InChI InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)
Affinity DataIC50: 1.05E+4nMAssay Description:Inhibition of EGFR after 60 mins by radiometric assayMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM11242(5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...)
Show SMILES Oc1ccc(Cl)cc1C(=O)Nc1ccc(cc1Cl)[N+]([O-])=O
Show InChI InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)
Affinity DataIC50: 1.05E+4nMAssay Description:Inhibition of Src kinaseMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM11242(5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...)
Show SMILES Oc1ccc(Cl)cc1C(=O)Nc1ccc(cc1Cl)[N+]([O-])=O
Show InChI InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)
Affinity DataIC50: 1.31E+4nMAssay Description:Inhibition of FGFR-1 after 60 mins by radiometric assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM11242(5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...)
Show SMILES Oc1ccc(Cl)cc1C(=O)Nc1ccc(cc1Cl)[N+]([O-])=O
Show InChI InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)
Affinity DataIC50: 2.31E+4nMAssay Description:Inhibition of VEGFR2 after 60 mins by radiometric assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM11242(5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...)
Show SMILES Oc1ccc(Cl)cc1C(=O)Nc1ccc(cc1Cl)[N+]([O-])=O
Show InChI InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)
Affinity DataIC50: 2.38E+4nMAssay Description:Inhibition of LYN after 60 mins by radiometric assayMore data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM11242(5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...)
Show SMILES Oc1ccc(Cl)cc1C(=O)Nc1ccc(cc1Cl)[N+]([O-])=O
Show InChI InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)
Affinity DataIC50: 2.78E+4nMAssay Description:Inhibition of KIT after 60 mins by radiometric assayMore data for this Ligand-Target Pair
TargetAurora kinase A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM11242(5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...)
Show SMILES Oc1ccc(Cl)cc1C(=O)Nc1ccc(cc1Cl)[N+]([O-])=O
Show InChI InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)
Affinity DataIC50: 5.41E+4nMAssay Description:Inhibition of Aurora-A after 60 mins by radiometric assayMore data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM11242(5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...)
Show SMILES Oc1ccc(Cl)cc1C(=O)Nc1ccc(cc1Cl)[N+]([O-])=O
Show InChI InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)
Affinity DataIC50: 5.94E+4nMAssay Description:Inhibition of Akt1 after 60 mins by radiometric assayMore data for this Ligand-Target Pair
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM11242(5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...)
Show SMILES Oc1ccc(Cl)cc1C(=O)Nc1ccc(cc1Cl)[N+]([O-])=O
Show InChI InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)
Affinity DataIC50: 6.78E+4nMAssay Description:Inhibition of TIE2 after 60 mins by radiometric assayMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM11242(5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...)
Show SMILES Oc1ccc(Cl)cc1C(=O)Nc1ccc(cc1Cl)[N+]([O-])=O
Show InChI InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)
Affinity DataIC50: 7.75E+4nMAssay Description:Inhibition of GSK3-beta after 60 mins by radiometric assayMore data for this Ligand-Target Pair
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM11242(5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...)
Show SMILES Oc1ccc(Cl)cc1C(=O)Nc1ccc(cc1Cl)[N+]([O-])=O
Show InChI InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)
Affinity DataIC50: 8.39E+4nMAssay Description:Inhibition of PDK1 after 60 mins by radiometric assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM11242(5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...)
Show SMILES Oc1ccc(Cl)cc1C(=O)Nc1ccc(cc1Cl)[N+]([O-])=O
Show InChI InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of Abl1 after 60 mins by radiometric assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM11242(5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...)
Show SMILES Oc1ccc(Cl)cc1C(=O)Nc1ccc(cc1Cl)[N+]([O-])=O
Show InChI InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of B-Raf after 60 mins by radiometric assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM11242(5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...)
Show SMILES Oc1ccc(Cl)cc1C(=O)Nc1ccc(cc1Cl)[N+]([O-])=O
Show InChI InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of Erk2 after 60 mins by radiometric assayMore data for this Ligand-Target Pair
TargetReplicase polyprotein 1ab(2019-nCoV)
Institut Pasteur Korea

LigandPNGBDBM11242(5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...)
Show SMILES Oc1ccc(Cl)cc1C(=O)Nc1ccc(cc1Cl)[N+]([O-])=O
Show InChI InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)
Affinity DataIC50: 280nMAssay Description:Ten-point DRCs were generated for each drug. Vero cells were seeded at 1.2  104 cells per well in DMEM, supplemented with 2% FBS and 1 ...More data for this Ligand-Target Pair
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
National Taiwan University

LigandPNGBDBM11242(5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...)
Show SMILES Oc1ccc(Cl)cc1C(=O)Nc1ccc(cc1Cl)[N+]([O-])=O
Show InChI InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)
Affinity DataIC50: 5.00E+4nMAssay Description:This is a review article.More data for this Ligand-Target Pair
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
National Taiwan University

LigandPNGBDBM11242(5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...)
Show SMILES Oc1ccc(Cl)cc1C(=O)Nc1ccc(cc1Cl)[N+]([O-])=O
Show InChI InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)
Affinity DataIC50: 5.00E+4nMAssay Description:This is a review article.More data for this Ligand-Target Pair
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
National Taiwan University

LigandPNGBDBM11242(5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...)
Show SMILES Oc1ccc(Cl)cc1C(=O)Nc1ccc(cc1Cl)[N+]([O-])=O
Show InChI InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of SARS Co-V 3CL proteaseMore data for this Ligand-Target Pair
TargetProtein kinase C alpha type(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM11242(5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...)
Show SMILES Oc1ccc(Cl)cc1C(=O)Nc1ccc(cc1Cl)[N+]([O-])=O
Show InChI InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of PKC-alpha after 60 mins by radiometric assayMore data for this Ligand-Target Pair