BDBM116257 US10035794, Example 34::US10683287, Example 34::US8637508, 34

SMILES: C[C@]1(CO[C@@](C(=N1)N)(C)C(F)(F)F)c2c(ccc(n2)NC(=O)c3c(cc(cn3)C(F)(F)F)Cl)F

InChI Key: InChIKey=PSBBWFNMHDUTRH-UHFFFAOYSA-N

Data: 27 IC50

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 27 hits for monomerid = 116257   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cathepsin E (Human)	BDBM116257 (US8637508, 34 | US10035794, Example 34 | US1068328...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.64E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Amyloid-beta precursor protein (Human)	BDBM116257 (US8637508, 34 | US10035794, Example 34 | US1068328...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Cathepsin E (Human)	BDBM116257 (US8637508, 34 | US10035794, Example 34 | US1068328...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.64E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Cathepsin D (Human)	BDBM116257 (US8637508, 34 | US10035794, Example 34 | US1068328...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.05E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Beta-secretase 2 (Human)	BDBM116257 (US8637508, 34 | US10035794, Example 34 | US1068328...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Beta-secretase 1 (Human)	BDBM116257 (US8637508, 34 | US10035794, Example 34 | US1068328...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 2C9 (Human)	BDBM116257 (US8637508, 34 | US10035794, Example 34 | US1068328...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Amyloid-beta precursor protein (Human)	BDBM116257 (US8637508, 34 | US10035794, Example 34 | US1068328...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Amyloid-beta precursor protein (Human)	BDBM116257 (US8637508, 34 | US10035794, Example 34 | US1068328...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM116257 (US8637508, 34 | US10035794, Example 34 | US1068328...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 2D6 (Human)	BDBM116257 (US8637508, 34 | US10035794, Example 34 | US1068328...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.34E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 3A4 (Human)	BDBM116257 (US8637508, 34 | US10035794, Example 34 | US1068328...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.09E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM116257 (US8637508, 34 | US10035794, Example 34 | US1068328...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Amyloid-beta precursor protein (Human)	BDBM116257 (US8637508, 34 | US10035794, Example 34 | US1068328...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Beta-secretase 1 (Human)	BDBM116257 (US8637508, 34 | US10035794, Example 34 | US1068328...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7	n/a	n/a	n/a	n/a	4.5	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cathepsin D (Human)	BDBM116257 (US8637508, 34 | US10035794, Example 34 | US1068328...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.05E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Beta-secretase 2 (Human)	BDBM116257 (US8637508, 34 | US10035794, Example 34 | US1068328...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Beta-secretase 1 (Human)	BDBM116257 (US8637508, 34 | US10035794, Example 34 | US1068328...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Beta-secretase 1 (Human)	BDBM116257 (US8637508, 34 | US10035794, Example 34 | US1068328...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Beta-secretase 1 (Chinese hamster)	BDBM116257 (US8637508, 34 | US10035794, Example 34 | US1068328...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Beta-secretase 2 (Human)	BDBM116257 (US8637508, 34 | US10035794, Example 34 | US1068328...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Beta-secretase 2 (Human)	BDBM116257 (US8637508, 34 | US10035794, Example 34 | US1068328...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Beta-secretase 1 (Human)	BDBM116257 (US8637508, 34 | US10035794, Example 34 | US1068328...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Beta-secretase 2 (Human)	BDBM116257 (US8637508, 34 | US10035794, Example 34 | US1068328...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	30	n/a	n/a	n/a	n/a	4.5	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Beta-secretase 1 (Human)	BDBM116257 (US8637508, 34 | US10035794, Example 34 | US1068328...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7	n/a	n/a	n/a	n/a	4.5	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Isocitrate dehydrogenase [NADP] cytoplasmic [R132H] (Human)	BDBM116257 (US8637508, 34 | US10035794, Example 34 | US1068328...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Beta-secretase 2 (Human)	BDBM116257 (US8637508, 34 | US10035794, Example 34 | US1068328...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	30	n/a	n/a	n/a	n/a	4.5	25
TBA									Citation and Details
					More data for this Ligand-Target Pair