BDBM116257 US10035794, Example 34::US10683287, Example 34::US8637508, 34

SMILES C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1nc(NC(=O)c2ncc(cc2Cl)C(F)(F)F)ccc1F

InChI Key InChIKey=PSBBWFNMHDUTRH-DLBZAZTESA-N

Data  27 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 116257   

TargetBeta-secretase 1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM116257(US10035794, Example 34 | US10683287, Example 34 | ...)
Affinity DataIC50:  7nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-1 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
TargetBeta-secretase 2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM116257(US10035794, Example 34 | US10683287, Example 34 | ...)
Affinity DataIC50:  30nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-2 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
In DepthDetails US Patent