BDBM14028 (S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINE::4-methyl-5-{[(2S)-2-methyl-1,4-diazepane-1-]sulfonyl}isoquinoline::H-1152::H-1152P

SMILES: C[C@H]1CNCCCN1S(=O)(=O)c1cccc2cncc(C)c12

InChI Key: InChIKey=AWDORCFLUJZUQS-UHFFFAOYSA-N

Data: 9 KI  18 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 32 hits for monomerid = 14028   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP-dependent protein kinase catalytic subunit alpha [L49I] (Bovine)	BDBM14028 (H-1152 | 4-methyl-5-{[(2S)-2-methyl-1,4-diazepane-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	426	n/a	n/a	n/a	n/a	6.8	25
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Rho-associated protein kinase 2 (Human)	BDBM14028 (H-1152 | 4-methyl-5-{[(2S)-2-methyl-1,4-diazepane-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Human)	BDBM14028 (H-1152 | 4-methyl-5-{[(2S)-2-methyl-1,4-diazepane-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
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Rho-associated protein kinase 1 (Human)	BDBM14028 (H-1152 | 4-methyl-5-{[(2S)-2-methyl-1,4-diazepane-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
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Leucine-rich repeat serine/threonine-protein kinase 2 (Human)	BDBM14028 (H-1152 | 4-methyl-5-{[(2S)-2-methyl-1,4-diazepane-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	244	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Human)	BDBM14028 (H-1152 | 4-methyl-5-{[(2S)-2-methyl-1,4-diazepane-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Human)	BDBM14028 (H-1152 | 4-methyl-5-{[(2S)-2-methyl-1,4-diazepane-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (Human)	BDBM14028 (H-1152 | 4-methyl-5-{[(2S)-2-methyl-1,4-diazepane-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (Human)	BDBM14028 (H-1152 | 4-methyl-5-{[(2S)-2-methyl-1,4-diazepane-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	104	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Human)	BDBM14028 (H-1152 | 4-methyl-5-{[(2S)-2-methyl-1,4-diazepane-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	45	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (Human)	BDBM14028 (H-1152 | 4-methyl-5-{[(2S)-2-methyl-1,4-diazepane-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (Human)	BDBM14028 (H-1152 | 4-methyl-5-{[(2S)-2-methyl-1,4-diazepane-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	244	n/a	n/a	n/a	n/a	n/a	n/a
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cAMP-dependent protein kinase catalytic subunit alpha [V123M,Q181K,T183A] (Bovine)	BDBM14028 (H-1152 | 4-methyl-5-{[(2S)-2-methyl-1,4-diazepane-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	223	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit alpha (Bovine)	BDBM14028 (H-1152 | 4-methyl-5-{[(2S)-2-methyl-1,4-diazepane-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	394	n/a	n/a	n/a	n/a	6.8	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit alpha [V123M] (Bovine)	BDBM14028 (H-1152 | 4-methyl-5-{[(2S)-2-methyl-1,4-diazepane-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.52E+3	n/a	n/a	n/a	n/a	6.8	25
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cAMP-dependent protein kinase catalytic subunit alpha [T183A] (Bovine)	BDBM14028 (H-1152 | 4-methyl-5-{[(2S)-2-methyl-1,4-diazepane-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	109	n/a	n/a	n/a	n/a	n/a	n/a
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cAMP-dependent protein kinase catalytic subunit alpha [E127D] (Bovine)	BDBM14028 (H-1152 | 4-methyl-5-{[(2S)-2-methyl-1,4-diazepane-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	493	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit alpha [Q181K,T183A] (Bovine)	BDBM14028 (H-1152 | 4-methyl-5-{[(2S)-2-methyl-1,4-diazepane-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	109	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit alpha [V123M,T183A] (Bovine)	BDBM14028 (H-1152 | 4-methyl-5-{[(2S)-2-methyl-1,4-diazepane-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	293	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit alpha [L49I,Q181K,T183A] (Bovine)	BDBM14028 (H-1152 | 4-methyl-5-{[(2S)-2-methyl-1,4-diazepane-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	58	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit alpha [L49I,V123M,Q181K,T183A] (Bovine)	BDBM14028 (H-1152 | 4-methyl-5-{[(2S)-2-methyl-1,4-diazepane-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	89	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit alpha [L49I,V123M,E127D,Q181K,T183A] (Bovine)	BDBM14028 (H-1152 | 4-methyl-5-{[(2S)-2-methyl-1,4-diazepane-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	149	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Bovine)	BDBM14028 (H-1152 | 4-methyl-5-{[(2S)-2-methyl-1,4-diazepane-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<45	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Human)	BDBM14028 (H-1152 | 4-methyl-5-{[(2S)-2-methyl-1,4-diazepane-...) Show SMILES Show InChI	GoogleScholar	UniChem		1.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Human)	BDBM14028 (H-1152 | 4-methyl-5-{[(2S)-2-methyl-1,4-diazepane-...) Show SMILES Show InChI	GoogleScholar	UniChem		6	-11.4	n/a	n/a	n/a	n/a	n/a	7.6	30
TBA									Citation and Details
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Human)	BDBM14028 (H-1152 | 4-methyl-5-{[(2S)-2-methyl-1,4-diazepane-...) Show SMILES Show InChI	GoogleScholar	UniChem		6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase PLK4 (Human)	BDBM14028 (H-1152 | 4-methyl-5-{[(2S)-2-methyl-1,4-diazepane-...) Show SMILES Show InChI	GoogleScholar	UniChem		120	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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cAMP-dependent protein kinase catalytic subunit alpha (Mouse)	BDBM14028 (H-1152 | 4-methyl-5-{[(2S)-2-methyl-1,4-diazepane-...) Show SMILES Show InChI	GoogleScholar	UniChem		340	-8.97	n/a	n/a	n/a	n/a	n/a	7.6	30
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Myosin light chain kinase, smooth muscle (Human)	BDBM14028 (H-1152 | 4-methyl-5-{[(2S)-2-methyl-1,4-diazepane-...) Show SMILES Show InChI	GoogleScholar	UniChem		1.01E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase PLK3 (Human)	BDBM14028 (H-1152 | 4-methyl-5-{[(2S)-2-methyl-1,4-diazepane-...) Show SMILES Show InChI	GoogleScholar	UniChem		>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK2 (Human)	BDBM14028 (H-1152 | 4-methyl-5-{[(2S)-2-methyl-1,4-diazepane-...) Show SMILES Show InChI	GoogleScholar	UniChem		>2.00E+4	>-6.34	n/a	n/a	n/a	n/a	n/a	7.5	22
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK1 (Human)	BDBM14028 (H-1152 | 4-methyl-5-{[(2S)-2-methyl-1,4-diazepane-...) Show SMILES Show InChI	GoogleScholar	UniChem		>2.00E+4	>-6.34	n/a	n/a	n/a	n/a	n/a	7.5	22
TBA									Citation and Details
					More data for this Ligand-Target Pair