BDBM158154 US10081622, Compound 11::US10370379, Entrectinib::US11059827, Compound Entrectinib::US11267806, Compound T-12::US9029356, 11::US9255087, 11::US9616059, 11

SMILES: CN1CCN(CC1)c2ccc(c(c2)NC3CCOCC3)C(=O)Nc4c5cc(ccc5[nH]n4)Cc6cc(cc(c6)F)F

InChI Key: InChIKey=HAYYBYPASCDWEQ-UHFFFAOYSA-N

Data: 1 KI  169 IC50

PDB links: 2 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 170 hits for monomerid = 158154   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
ALK tyrosine kinase receptor (Human)	BDBM158154 (US9029356, 11 | US9255087, 11 | US10081622, Compou...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	55	n/a	n/a	n/a	n/a	7.5	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Human)	BDBM158154 (US9029356, 11 | US9255087, 11 | US10081622, Compou...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	263	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase B (Human)	BDBM158154 (US9029356, 11 | US9255087, 11 | US10081622, Compou...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	338	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Human)	BDBM158154 (US9029356, 11 | US9255087, 11 | US10081622, Compou...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Human)	BDBM158154 (US9029356, 11 | US9255087, 11 | US10081622, Compou...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM158154 (US9029356, 11 | US9255087, 11 | US10081622, Compou...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor [L1196M] (Human)	BDBM158154 (US9029356, 11 | US9255087, 11 | US10081622, Compou...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Human)	BDBM158154 (US9029356, 11 | US9255087, 11 | US10081622, Compou...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
BDNF/NT-3 growth factors receptor (Human)	BDBM158154 (US9029356, 11 | US9255087, 11 | US10081622, Compou...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
NT-3 growth factor receptor (Human)	BDBM158154 (US9029356, 11 | US9255087, 11 | US10081622, Compou...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM158154 (US9029356, 11 | US9255087, 11 | US10081622, Compou...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor [L1196M] (Human)	BDBM158154 (US9029356, 11 | US9255087, 11 | US10081622, Compou...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Human)	BDBM158154 (US9029356, 11 | US9255087, 11 | US10081622, Compou...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
BDNF/NT-3 growth factors receptor (Human)	BDBM158154 (US9029356, 11 | US9255087, 11 | US10081622, Compou...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
NT-3 growth factor receptor (Human)	BDBM158154 (US9029356, 11 | US9255087, 11 | US10081622, Compou...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM158154 (US9029356, 11 | US9255087, 11 | US10081622, Compou...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor [L1196M] (Human)	BDBM158154 (US9029356, 11 | US9255087, 11 | US10081622, Compou...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Human)	BDBM158154 (US9029356, 11 | US9255087, 11 | US10081622, Compou...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
BDNF/NT-3 growth factors receptor (Human)	BDBM158154 (US9029356, 11 | US9255087, 11 | US10081622, Compou...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
NT-3 growth factor receptor (Human)	BDBM158154 (US9029356, 11 | US9255087, 11 | US10081622, Compou...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM158154 (US9029356, 11 | US9255087, 11 | US10081622, Compou...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor [L1196M] (Human)	BDBM158154 (US9029356, 11 | US9255087, 11 | US10081622, Compou...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Human)	BDBM158154 (US9029356, 11 | US9255087, 11 | US10081622, Compou...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
BDNF/NT-3 growth factors receptor (Human)	BDBM158154 (US9029356, 11 | US9255087, 11 | US10081622, Compou...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
NT-3 growth factor receptor (Human)	BDBM158154 (US9029356, 11 | US9255087, 11 | US10081622, Compou...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM158154 (US9029356, 11 | US9255087, 11 | US10081622, Compou...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor [L1196M] (Human)	BDBM158154 (US9029356, 11 | US9255087, 11 | US10081622, Compou...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Human)	BDBM158154 (US9029356, 11 | US9255087, 11 | US10081622, Compou...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
BDNF/NT-3 growth factors receptor (Human)	BDBM158154 (US9029356, 11 | US9255087, 11 | US10081622, Compou...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
NT-3 growth factor receptor (Human)	BDBM158154 (US9029356, 11 | US9255087, 11 | US10081622, Compou...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM158154 (US9029356, 11 | US9255087, 11 | US10081622, Compou...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor [L1196M] (Human)	BDBM158154 (US9029356, 11 | US9255087, 11 | US10081622, Compou...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Human)	BDBM158154 (US9029356, 11 | US9255087, 11 | US10081622, Compou...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
BDNF/NT-3 growth factors receptor (Human)	BDBM158154 (US9029356, 11 | US9255087, 11 | US10081622, Compou...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
NT-3 growth factor receptor (Human)	BDBM158154 (US9029356, 11 | US9255087, 11 | US10081622, Compou...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM158154 (US9029356, 11 | US9255087, 11 | US10081622, Compou...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor [L1196M] (Human)	BDBM158154 (US9029356, 11 | US9255087, 11 | US10081622, Compou...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Human)	BDBM158154 (US9029356, 11 | US9255087, 11 | US10081622, Compou...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
BDNF/NT-3 growth factors receptor (Human)	BDBM158154 (US9029356, 11 | US9255087, 11 | US10081622, Compou...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
NT-3 growth factor receptor (Human)	BDBM158154 (US9029356, 11 | US9255087, 11 | US10081622, Compou...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM158154 (US9029356, 11 | US9255087, 11 | US10081622, Compou...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor [L1196M] (Human)	BDBM158154 (US9029356, 11 | US9255087, 11 | US10081622, Compou...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>200	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Human)	BDBM158154 (US9029356, 11 | US9255087, 11 | US10081622, Compou...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
BDNF/NT-3 growth factors receptor (Human)	BDBM158154 (US9029356, 11 | US9255087, 11 | US10081622, Compou...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
NT-3 growth factor receptor (Human)	BDBM158154 (US9029356, 11 | US9255087, 11 | US10081622, Compou...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM158154 (US9029356, 11 | US9255087, 11 | US10081622, Compou...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor [L1196M] (Human)	BDBM158154 (US9029356, 11 | US9255087, 11 | US10081622, Compou...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Human)	BDBM158154 (US9029356, 11 | US9255087, 11 | US10081622, Compou...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
BDNF/NT-3 growth factors receptor (Human)	BDBM158154 (US9029356, 11 | US9255087, 11 | US10081622, Compou...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
NT-3 growth factor receptor (Human)	BDBM158154 (US9029356, 11 | US9255087, 11 | US10081622, Compou...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair