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Found 27 Enz. Inhib. hit(s) with Target = 'High affinity nerve growth factor receptor' and Ligand = 'BDBM158154'
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Zoetis

Curated by ChEMBL
LigandPNGBDBM158154(US10081622, Compound 11 | US10370379, Entrectinib ...)
Affinity DataIC50:  0.220nMAssay Description:Inhibition of human wild type TrkA kinase domain expressed in mouse NIH/3T3 cells by HTRF assayMore data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Zoetis

Curated by ChEMBL
LigandPNGBDBM158154(US10081622, Compound 11 | US10370379, Entrectinib ...)
Affinity DataIC50:  0.600nMAssay Description:In each well of a 384-well plate, 1 nM-1.5 nM of wild type NTRK1 enzyme (BPS Bioscience; 40280) was incubated in a total of 12.5 μL of buffer (1...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Zoetis

Curated by ChEMBL
LigandPNGBDBM158154(US10081622, Compound 11 | US10370379, Entrectinib ...)
Affinity DataIC50:  0.600nMAssay Description:In each well of a 384-well plate, 1 nM-1.5 nM of wild type NTRK1 enzyme (BPS Bioscience; 40280) was incubated in a total of 12.5 μL of buffer (1...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Zoetis

Curated by ChEMBL
LigandPNGBDBM158154(US10081622, Compound 11 | US10370379, Entrectinib ...)
Affinity DataIC50:  1nMAssay Description:The compound was evaluated for its binding affinity against mutant Y50F scytalone dehydrataseMore data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Zoetis

Curated by ChEMBL
LigandPNGBDBM158154(US10081622, Compound 11 | US10370379, Entrectinib ...)
Affinity DataIC50:  1nMAssay Description:Inhibition of TRKA (unknown origin) in presence of gamma33-ATPMore data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Zoetis

Curated by ChEMBL
LigandPNGBDBM158154(US10081622, Compound 11 | US10370379, Entrectinib ...)
Affinity DataIC50:  1nMAssay Description:Inhibition of TRKA (unknown origin) by radiometric assayMore data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Zoetis

Curated by ChEMBL
LigandPNGBDBM158154(US10081622, Compound 11 | US10370379, Entrectinib ...)
Affinity DataIC50:  1nMAssay Description:Inhibition of TrkA (unknown origin)More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Zoetis

Curated by ChEMBL
LigandPNGBDBM158154(US10081622, Compound 11 | US10370379, Entrectinib ...)
Affinity DataIC50:  1nMAssay Description:Inhibition of TrkA (unknown origin) by radiometric assayMore data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Zoetis

Curated by ChEMBL
LigandPNGBDBM158154(US10081622, Compound 11 | US10370379, Entrectinib ...)
Affinity DataIC50:  1nMAssay Description:Inhibition of TRKA (unknown origin) by radiometric assayMore data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Zoetis

Curated by ChEMBL
LigandPNGBDBM158154(US10081622, Compound 11 | US10370379, Entrectinib ...)
Affinity DataIC50: <1nMAssay Description:Kinase assay: After the buffer was prepared, the enzyme was mixed with different concentrations of pre-diluted compounds in duplex, and allowed to st...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Zoetis

Curated by ChEMBL
LigandPNGBDBM158154(US10081622, Compound 11 | US10370379, Entrectinib ...)
Affinity DataIC50: <1nMAssay Description:Kinase assay: After the buffer was prepared, the enzyme was mixed with different concentrations of pre-diluted compounds in duplex, and allowed to st...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Zoetis

Curated by ChEMBL
LigandPNGBDBM158154(US10081622, Compound 11 | US10370379, Entrectinib ...)
Affinity DataIC50: <1nMAssay Description:Kinase assay: After the buffer was prepared, the enzyme was mixed with different concentrations of pre-diluted compounds in duplex, and allowed to st...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Zoetis

Curated by ChEMBL
LigandPNGBDBM158154(US10081622, Compound 11 | US10370379, Entrectinib ...)
Affinity DataIC50: <1nMAssay Description:Kinase assay: After the buffer was prepared, the enzyme was mixed with different concentrations of pre-diluted compounds in duplex, and allowed to st...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Zoetis

Curated by ChEMBL
LigandPNGBDBM158154(US10081622, Compound 11 | US10370379, Entrectinib ...)
Affinity DataIC50: <1nMAssay Description:Kinase assay: After the buffer was prepared, the enzyme was mixed with different concentrations of pre-diluted compounds in duplex, and allowed to st...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Zoetis

Curated by ChEMBL
LigandPNGBDBM158154(US10081622, Compound 11 | US10370379, Entrectinib ...)
Affinity DataIC50: <1nMAssay Description:Kinase assay: After the buffer was prepared, the enzyme was mixed with different concentrations of pre-diluted compounds in duplex, and allowed to st...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Zoetis

Curated by ChEMBL
LigandPNGBDBM158154(US10081622, Compound 11 | US10370379, Entrectinib ...)
Affinity DataIC50: <1nMAssay Description:Kinase assay: After the buffer was prepared, the enzyme was mixed with different concentrations of pre-diluted compounds in duplex, and allowed to st...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Zoetis

Curated by ChEMBL
LigandPNGBDBM158154(US10081622, Compound 11 | US10370379, Entrectinib ...)
Affinity DataIC50: <1nMAssay Description:Kinase assay: After the buffer was prepared, the enzyme was mixed with different concentrations of pre-diluted compounds in duplex, and allowed to st...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Zoetis

Curated by ChEMBL
LigandPNGBDBM158154(US10081622, Compound 11 | US10370379, Entrectinib ...)
Affinity DataIC50: <1nMAssay Description:Kinase assay: After the buffer was prepared, the enzyme was mixed with different concentrations of pre-diluted compounds in duplex, and allowed to st...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Zoetis

Curated by ChEMBL
LigandPNGBDBM158154(US10081622, Compound 11 | US10370379, Entrectinib ...)
Affinity DataIC50: <1nMAssay Description:Kinase assay: After the buffer was prepared, the enzyme was mixed with different concentrations of pre-diluted compounds in duplex, and allowed to st...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Zoetis

Curated by ChEMBL
LigandPNGBDBM158154(US10081622, Compound 11 | US10370379, Entrectinib ...)
Affinity DataIC50: <1nMAssay Description:Kinase assay: After the buffer was prepared, the enzyme was mixed with different concentrations of pre-diluted compounds in duplex, and allowed to st...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Zoetis

Curated by ChEMBL
LigandPNGBDBM158154(US10081622, Compound 11 | US10370379, Entrectinib ...)
Affinity DataIC50: <1nMAssay Description:Kinase assay: After the buffer was prepared, the enzyme was mixed with different concentrations of pre-diluted compounds in duplex, and allowed to st...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Zoetis

Curated by ChEMBL
LigandPNGBDBM158154(US10081622, Compound 11 | US10370379, Entrectinib ...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of human TRKA assessed as decreased enzymatic reactions measured after 1 hr by mobility shift assayMore data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Zoetis

Curated by ChEMBL
LigandPNGBDBM158154(US10081622, Compound 11 | US10370379, Entrectinib ...)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of recombinant His-tagged human TRKA (441 to 796 residues) expressed in baculovirus expression system using 5-FAM-EEPLYWSFPAKKK-CONH2 as s...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Zoetis

Curated by ChEMBL
LigandPNGBDBM158154(US10081622, Compound 11 | US10370379, Entrectinib ...)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of human TrkA G667C mutant expressed in mouse NIH/3T3 cells by HTRF assayMore data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Zoetis

Curated by ChEMBL
LigandPNGBDBM158154(US10081622, Compound 11 | US10370379, Entrectinib ...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human TEL (336 residues) fused-TRKA (440 to 796 residues) (unknown origin) expressed in mouse BAF3 cells assessed as cell growth inhibi...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Zoetis

Curated by ChEMBL
LigandPNGBDBM158154(US10081622, Compound 11 | US10370379, Entrectinib ...)
Affinity DataIC50: <10nMAssay Description:Inhibition TRKA (unknown origin)More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Zoetis

Curated by ChEMBL
LigandPNGBDBM158154(US10081622, Compound 11 | US10370379, Entrectinib ...)
Affinity DataIC50:  45nMAssay Description:Inhibition of human TrkA G595R mutant expressed in mouse NIH/3T3 cells by HTRF assayMore data for this Ligand-Target Pair