BDBM17055 (18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-triazahexacyclo[19.6.1.1^{7,14}.0^{2,6}.0^{8,13}.0^{22,27}]nonacosa-1(28),2(6),7(29),8(13),9,11,22(27),23,25-nonaene-3,5-dione::(9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-di(metheno)dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione::K00587a::LY 333531::LY-333531::LY333531::Ruboxistaurin::cid_153999

SMILES: CN(C)C[C@@H]1CCn2cc(C3=C(C(=O)NC3=O)c3cn(CCO1)c1ccccc31)c1ccccc21

InChI Key: InChIKey=ZCBUQCWBWNUWSU-UHFFFAOYSA-N

Data: 6 KI  37 IC50  852 Kd

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 901 hits for monomerid = 17055   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
3-phosphoinositide-dependent protein kinase 1 [51-359] (Human)	BDBM17055 ((9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	750	n/a	n/a	n/a	n/a	7.5	30
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3-phosphoinositide-dependent protein kinase 1 [51-359,V143T] (Human)	BDBM17055 ((9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	500	n/a	n/a	n/a	n/a	7.5	30
TBA									Citation and Details
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3-phosphoinositide-dependent protein kinase 1 [51-359,L159M] (Human)	BDBM17055 ((9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	600	n/a	n/a	n/a	n/a	7.5	30
TBA									Citation and Details
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3-phosphoinositide-dependent protein kinase 1 [51-359,A162V] (Human)	BDBM17055 ((9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	743	n/a	n/a	n/a	n/a	7.5	30
TBA									Citation and Details
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3-phosphoinositide-dependent protein kinase 1 [51-359,E166D] (Human)	BDBM17055 ((9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	610	n/a	n/a	n/a	n/a	7.5	30
TBA									Citation and Details
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3-phosphoinositide-dependent protein kinase 1 [51-359,T222A] (Human)	BDBM17055 ((9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	734	n/a	n/a	n/a	n/a	7.5	30
TBA									Citation and Details
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3-phosphoinositide-dependent protein kinase 1 [51-359,V143T,T222A] (Human)	BDBM17055 ((9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	500	n/a	n/a	n/a	n/a	7.5	30
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Dual specificity protein kinase CLK1 [R432A] (Human)	BDBM17055 ((9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	910	n/a	n/a	n/a	7.4	23
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Dual specificity protein kinase CLK4 (Human)	BDBM17055 ((9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.90E+3	n/a	n/a	n/a	7.4	23
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Mitogen-activated protein kinase 15 (Human)	BDBM17055 ((9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	88	n/a	n/a	n/a	7.4	25
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Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM17055 ((9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.90E+3	n/a	n/a	n/a	7.4	25
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Receptor-type tyrosine-protein kinase FLT3 [D835H] (Human)	BDBM17055 ((9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	210	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
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Receptor-type tyrosine-protein kinase FLT3 [D835Y] (Human)	BDBM17055 ((9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	130	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM17055 ((9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	280	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
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Receptor-type tyrosine-protein kinase FLT3 [N841I] (Human)	BDBM17055 ((9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	980	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Human)	BDBM17055 ((9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.60E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Mitogen-activated protein kinase kinase kinase kinase 3 (Human)	BDBM17055 ((9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	8.40E+3	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase 3 (Human)	BDBM17055 ((9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	960	n/a	n/a	n/a	n/a	n/a
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cAMP-dependent protein kinase catalytic subunit alpha (Human)	BDBM17055 ((9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	5.40E+3	n/a	n/a	n/a	n/a	n/a
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Ribosomal protein S6 kinase alpha-4 (Human)	BDBM17055 ((9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	6.10E+3	n/a	n/a	n/a	n/a	n/a
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Ribosomal protein S6 kinase alpha-5 (Human)	BDBM17055 ((9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a
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STE20-like serine/threonine-protein kinase (Human)	BDBM17055 ((9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase 33 (Human)	BDBM17055 ((9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	3.10E+3	n/a	n/a	n/a	n/a	n/a
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Citron Rho-interacting kinase (Human)	BDBM17055 ((9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a
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Calcium/calmodulin-dependent protein kinase kinase 1 (Human)	BDBM17055 ((9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Calcium/calmodulin-dependent protein kinase kinase 2 (Human)	BDBM17055 ((9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Dual specificity protein kinase CLK2 (Human)	BDBM17055 ((9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	420	n/a	n/a	n/a	n/a	n/a
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Cyclin-G-associated kinase (Human)	BDBM17055 ((9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Serine/threonine-protein kinase LATS1 (Human)	BDBM17055 ((9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.60E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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cAMP-dependent protein kinase catalytic subunit beta (Human)	BDBM17055 ((9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	3.20E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Protein kinase C theta type (Human)	BDBM17055 ((9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Serine/threonine-protein kinase D2 (Human)	BDBM17055 ((9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	890	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase PLK4 (Human)	BDBM17055 ((9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	4.70E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Dual specificity tyrosine-phosphorylation-regulated kinase 1B (Human)	BDBM17055 ((9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	5.40E+3	n/a	n/a	n/a	n/a	n/a
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Glycogen synthase kinase-3 beta (Human)	BDBM17055 ((9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.60E+3	n/a	n/a	n/a	n/a	n/a
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Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (Human)	BDBM17055 ((9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	3.70E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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NUAK family SNF1-like kinase 2 (Human)	BDBM17055 ((9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	320	n/a	n/a	n/a	n/a	n/a
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AP2-associated protein kinase 1 (Human)	BDBM17055 ((9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	900	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
NUAK family SNF1-like kinase 1 (Human)	BDBM17055 ((9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a	n/a
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BMP-2-inducible protein kinase (Human)	BDBM17055 ((9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	430	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Serine/threonine-protein kinase Chk1 (Human)	BDBM17055 ((9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	540	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Casein kinase II subunit alpha (Human)	BDBM17055 ((9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	3.60E+3	n/a	n/a	n/a	n/a	n/a
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Casein kinase II subunit alpha' (Human)	BDBM17055 ((9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	3.40E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Mitogen-activated protein kinase kinase kinase 9 (Human)	BDBM17055 ((9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a
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Myosin light chain kinase, smooth muscle (Human)	BDBM17055 ((9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	290	n/a	n/a	n/a	n/a	n/a
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Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (Human)	BDBM17055 ((9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	690	n/a	n/a	n/a	n/a	n/a
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Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (Human)	BDBM17055 ((9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	830	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase N1 (Human)	BDBM17055 ((9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	350	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase N2 (Human)	BDBM17055 ((9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase RIO1 (Human)	BDBM17055 ((9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	810	n/a	n/a	n/a	n/a	n/a
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