BDBM17055 (18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-triazahexacyclo[19.6.1.1^{7,14}.0^{2,6}.0^{8,13}.0^{22,27}]nonacosa-1(28),2(6),7(29),8(13),9,11,22(27),23,25-nonaene-3,5-dione::(9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-di(metheno)dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione::K00587a::LY 333531::LY-333531::LY333531::Ruboxistaurin::cid_153999
SMILES CN(C)C[C@@H]1CCn2cc(C3=C(C(=O)NC3=O)c3cn(CCO1)c1ccccc31)c1ccccc21
InChI Key InChIKey=ZCBUQCWBWNUWSU-SFHVURJKSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 7 hits for monomerid = 17055
Affinity DataIC50: 4.70nMAssay Description:Inhibition of DAG-activated human PKCbeta1 after 10 mins in presence of [32P]ATP by beta scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:Inhibition of DAG-activated human PKCgamma after 10 mins in presence of [32P]ATP by beta scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataIC50: 5.90nMAssay Description:Inhibition of DAG-activated human PKCbeta2 after 10 mins in presence of [32P]ATP by beta scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataIC50: 360nMAssay Description:Inhibition of DAG-activated human PKCalpha after 10 mins in presence of [32P]ATP by beta scintillation counting methodMore data for this Ligand-Target Pair
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
University College Cork
Curated by ChEMBL
University College Cork
Curated by ChEMBL
Affinity DataIC50: 750nMAssay Description:Inhibition of wild type PDK1 (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
University College Cork
Curated by ChEMBL
University College Cork
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:Inhibition of PIM1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 600nMAssay Description:Inhibition of DAG-activated human PKCepsilon after 10 mins in presence of [32P]ATP by beta scintillation counting methodMore data for this Ligand-Target Pair