BDBM19428 (2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl}phenyl)prop-2-enamide::(E)-N-hydroxy-3-[4-[[2-hydroxyethyl-[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]prop-2-enamide::CHEMBL356066::Dacinostat::LAQ-824::NVP-LAQ824

SMILES: OCCN(CCc1c[nH]c2ccccc12)Cc1ccc(\C=C\C(=O)NO)cc1

InChI Key: InChIKey=BWDQBBCUWLSASG-UHFFFAOYSA-N

Data: 9 KI  42 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 51 hits for monomerid = 19428   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone deacetylase 3 (Human)	BDBM19428 (NVP-LAQ824 | (2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 8 (Human)	BDBM19428 (NVP-LAQ824 | (2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.80	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 4 (Human)	BDBM19428 (NVP-LAQ824 | (2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.80	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 7 (Human)	BDBM19428 (NVP-LAQ824 | (2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 9 (Human)	BDBM19428 (NVP-LAQ824 | (2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 6 (Human)	BDBM19428 (NVP-LAQ824 | (2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Polyamine deacetylase HDAC10 (Human)	BDBM19428 (NVP-LAQ824 | (2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 11 (Human)	BDBM19428 (NVP-LAQ824 | (2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 1 (Human)	BDBM19428 (NVP-LAQ824 | (2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM19428 (NVP-LAQ824 | (2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.03E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Human)	BDBM19428 (NVP-LAQ824 | (2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 2 (Human)	BDBM19428 (NVP-LAQ824 | (2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 4 (Human)	BDBM19428 (NVP-LAQ824 | (2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 4 (Human)	BDBM19428 (NVP-LAQ824 | (2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 4 (Human)	BDBM19428 (NVP-LAQ824 | (2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 4 (Human)	BDBM19428 (NVP-LAQ824 | (2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 4 (Human)	BDBM19428 (NVP-LAQ824 | (2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 1 (Human)	BDBM19428 (NVP-LAQ824 | (2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM19428 (NVP-LAQ824 | (2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.03E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM19428 (NVP-LAQ824 | (2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.03E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM19428 (NVP-LAQ824 | (2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.03E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 2 (Human)	BDBM19428 (NVP-LAQ824 | (2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 1 (Human)	BDBM19428 (NVP-LAQ824 | (2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 3 (Human)	BDBM19428 (NVP-LAQ824 | (2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 8 (Human)	BDBM19428 (NVP-LAQ824 | (2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 1 (Human)	BDBM19428 (NVP-LAQ824 | (2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.60	n/a	n/a	n/a	n/a	8.0	37
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 3 (Human)	BDBM19428 (NVP-LAQ824 | (2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.60	n/a	n/a	n/a	n/a	8.0	37
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 4 [653-1084,H976Y] (Human)	BDBM19428 (NVP-LAQ824 | (2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.40	n/a	n/a	n/a	n/a	7.5	37
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 4 (Human)	BDBM19428 (NVP-LAQ824 | (2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	420	n/a	n/a	n/a	n/a	n/a	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 6 (Human)	BDBM19428 (NVP-LAQ824 | (2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8.30	n/a	n/a	n/a	n/a	n/a	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase (Human)	BDBM19428 (NVP-LAQ824 | (2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase (Human)	BDBM19428 (NVP-LAQ824 | (2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 7 (Human)	BDBM19428 (NVP-LAQ824 | (2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.24E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 3 (Human)	BDBM19428 (NVP-LAQ824 | (2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 1 (Human)	BDBM19428 (NVP-LAQ824 | (2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 5 (Human)	BDBM19428 (NVP-LAQ824 | (2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 1 (Human)	BDBM19428 (NVP-LAQ824 | (2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM19428 (NVP-LAQ824 | (2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.22E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 1 (Human)	BDBM19428 (NVP-LAQ824 | (2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 2 (Human)	BDBM19428 (NVP-LAQ824 | (2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 4 (Human)	BDBM19428 (NVP-LAQ824 | (2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 5 (Human)	BDBM19428 (NVP-LAQ824 | (2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	190	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 1 (Human)	BDBM19428 (NVP-LAQ824 | (2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl...) Show SMILES Show InChI	GoogleScholar	UniChem		0.600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 2 (Human)	BDBM19428 (NVP-LAQ824 | (2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl...) Show SMILES Show InChI	GoogleScholar	UniChem		1.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 3 (Human)	BDBM19428 (NVP-LAQ824 | (2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl...) Show SMILES Show InChI	GoogleScholar	UniChem		4.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 6 (Human)	BDBM19428 (NVP-LAQ824 | (2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl...) Show SMILES Show InChI	GoogleScholar	UniChem		9.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 8 (Human)	BDBM19428 (NVP-LAQ824 | (2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl...) Show SMILES Show InChI	GoogleScholar	UniChem		340	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 5 (Human)	BDBM19428 (NVP-LAQ824 | (2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl...) Show SMILES Show InChI	GoogleScholar	UniChem		420	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 4 (Human)	BDBM19428 (NVP-LAQ824 | (2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl...) Show SMILES Show InChI	GoogleScholar	UniChem		2.25E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 9 (Human)	BDBM19428 (NVP-LAQ824 | (2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl...) Show SMILES Show InChI	GoogleScholar	UniChem		9.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair