BDBM249466 US10072016, Compound 65::US10407433, Compound 65::US10913746, Compound 65::US11649240, Compound 65::US9434727, 65::US9777010, Compound 65
SMILES Fc1cccc(C2CCN(CC2)C(=O)c2nnc3ccc(cn23)C#N)c1C(F)(F)F
InChI Key InChIKey=TZIIUZZREBUIBM-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 45 hits for monomerid = 249466
TargetCytochrome P450 2D6(Homo sapiens (Human))
Albany College Of Pharmacy And Health Sciences
Curated by ChEMBL
Albany College Of Pharmacy And Health Sciences
Curated by ChEMBL
Affinity DataKi: 720nMAssay Description:Time dependent inhibition of CYP2D6 in human liver microsomes assessed as equilibrium inhibition binding constant in presence of NADPH by LC-MS/MS an...More data for this Ligand-Target Pair
TargetRetinol-binding protein 4(Homo sapiens (Human))
The Trustees Of Columbia University In The City Of New York
US Patent
The Trustees Of Columbia University In The City Of New York
US Patent
Affinity DataIC50: 12.7nMAssay Description:Binding of a desired RBP4 antagonist displaces retinol and induces hindrance for RBP4-TTR interaction resulting in the decreased FRET signal (FIG. 7 ...More data for this Ligand-Target Pair
TargetRetinol-binding protein 4(Homo sapiens (Human))
The Trustees Of Columbia University In The City Of New York
US Patent
The Trustees Of Columbia University In The City Of New York
US Patent
Affinity DataIC50: 5.73nMpH: 7.4 T: 2°CAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
TargetRetinol-binding protein 4(Homo sapiens (Human))
The Trustees Of Columbia University In The City Of New York
US Patent
The Trustees Of Columbia University In The City Of New York
US Patent
Affinity DataIC50: 5.36nMpH: 7.4 T: 2°CAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
TargetRetinol-binding protein 4(Homo sapiens (Human))
The Trustees Of Columbia University In The City Of New York
US Patent
The Trustees Of Columbia University In The City Of New York
US Patent
Affinity DataIC50: 12.8nMpH: 7.5 T: 2°CAssay Description:TR-FRET assay for retinol-induced RBP4-TTR interaction Binding of a desired RBP4 antagonist displaces retinol and induces hindrance for RBP4-TTR inte...More data for this Ligand-Target Pair
TargetRetinol-binding protein 4(Homo sapiens (Human))
The Trustees Of Columbia University In The City Of New York
US Patent
The Trustees Of Columbia University In The City Of New York
US Patent
Affinity DataIC50: 12.7nMpH: 7.5 T: 2°CAssay Description:TR-FRET assay for retinol-induced RBP4-TTR interaction Binding of a desired RBP4 antagonist displaces retinol and induces hindrance for RBP4-TTR inte...More data for this Ligand-Target Pair
TargetRetinol-binding protein 4(Homo sapiens (Human))
The Trustees Of Columbia University In The City Of New York
US Patent
The Trustees Of Columbia University In The City Of New York
US Patent
Affinity DataIC50: 16.1nMpH: 7.5 T: 2°CAssay Description:TR-FRET assay for retinol-induced RBP4-TTR interaction Binding of a desired RBP4 antagonist displaces retinol and induces hindrance for RBP4-TTR inte...More data for this Ligand-Target Pair
TargetRetinol-binding protein 4(Homo sapiens (Human))
The Trustees Of Columbia University In The City Of New York
US Patent
The Trustees Of Columbia University In The City Of New York
US Patent
Affinity DataIC50: 12.7nMpH: 7.5 T: 2°CAssay Description:TR-FRET assay for retinol-induced RBP4-TTR interaction Binding of a desired RBP4 antagonist displaces retinol and induces hindrance for RBP4-TTR inte...More data for this Ligand-Target Pair
TargetRetinol-binding protein 4(Homo sapiens (Human))
The Trustees Of Columbia University In The City Of New York
US Patent
The Trustees Of Columbia University In The City Of New York
US Patent
Affinity DataIC50: 4.13nMpH: 7.5Assay Description:Binding of a desired RBP4 antagonist displaces retinol and induces hindrance for RBP4-TTR interaction resulting in the decreased FRET signal (FIG. 7)...More data for this Ligand-Target Pair
Affinity DataIC50: 12.8nMpH: 7.4 T: 2°CAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
TargetRetinol-binding protein 4(Homo sapiens (Human))
The Trustees Of Columbia University In The City Of New York
US Patent
The Trustees Of Columbia University In The City Of New York
US Patent
Affinity DataIC50: 5.36nMpH: 7.5Assay Description:Binding of a desired RBP4 antagonist displaces retinol and induces hindrance for RBP4-TTR interaction resulting in the decreased FRET signal (FIG. 7)...More data for this Ligand-Target Pair
Affinity DataIC50: 12.7nMpH: 7.4 T: 2°CAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
TargetRetinol-binding protein 4(Homo sapiens (Human))
The Trustees Of Columbia University In The City Of New York
US Patent
The Trustees Of Columbia University In The City Of New York
US Patent
Affinity DataIC50: 5.36nMpH: 7.5Assay Description:Binding of a desired RBP4 antagonist displaces retinol and induces hindrance for RBP4-TTR interaction resulting in the decreased FRET signal (FIG. 7)...More data for this Ligand-Target Pair
Affinity DataIC50: 12.7nMpH: 7.4 T: 2°CAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
TargetRetinol-binding protein 4(Homo sapiens (Human))
The Trustees Of Columbia University In The City Of New York
US Patent
The Trustees Of Columbia University In The City Of New York
US Patent
Affinity DataIC50: 5.36nMpH: 7.5Assay Description:Binding of a desired RBP4 antagonist displaces retinol and induces hindrance for RBP4-TTR interaction resulting in the decreased FRET signal (FIG. 7)...More data for this Ligand-Target Pair
Affinity DataIC50: 12.7nMpH: 7.4 T: 2°CAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
TargetRetinol-binding protein 4(Homo sapiens (Human))
The Trustees Of Columbia University In The City Of New York
US Patent
The Trustees Of Columbia University In The City Of New York
US Patent
Affinity DataIC50: 4.13nMAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
TargetRetinol-binding protein 4(Homo sapiens (Human))
The Trustees Of Columbia University In The City Of New York
US Patent
The Trustees Of Columbia University In The City Of New York
US Patent
Affinity DataIC50: 5.36nMAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
TargetRetinol-binding protein 4(Homo sapiens (Human))
The Trustees Of Columbia University In The City Of New York
US Patent
The Trustees Of Columbia University In The City Of New York
US Patent
Affinity DataIC50: 5.36nMAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
TargetRetinol-binding protein 4(Homo sapiens (Human))
The Trustees Of Columbia University In The City Of New York
US Patent
The Trustees Of Columbia University In The City Of New York
US Patent
Affinity DataIC50: 5.36nMAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
TargetRetinol-binding protein 4(Homo sapiens (Human))
The Trustees Of Columbia University In The City Of New York
US Patent
The Trustees Of Columbia University In The City Of New York
US Patent
Affinity DataIC50: 4.13nMAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
TargetRetinol-binding protein 4(Homo sapiens (Human))
The Trustees Of Columbia University In The City Of New York
US Patent
The Trustees Of Columbia University In The City Of New York
US Patent
Affinity DataIC50: 5.36nMAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
TargetRetinol-binding protein 4(Homo sapiens (Human))
The Trustees Of Columbia University In The City Of New York
US Patent
The Trustees Of Columbia University In The City Of New York
US Patent
Affinity DataIC50: 5.36nMAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
TargetRetinol-binding protein 4(Homo sapiens (Human))
The Trustees Of Columbia University In The City Of New York
US Patent
The Trustees Of Columbia University In The City Of New York
US Patent
Affinity DataIC50: 5.36nMAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))
Albany College Of Pharmacy And Health Sciences
Curated by ChEMBL
Albany College Of Pharmacy And Health Sciences
Curated by ChEMBL
Affinity DataIC50: 7.40E+4nMAssay Description:Inhibition of recombinant human CYP3A4 expressed in insect cell microsomes in presence of NADPH-regenerating system after 15 to 45 mins by fluorescen...More data for this Ligand-Target Pair
TargetCytochrome P450 2C19(Homo sapiens (Human))
Albany College Of Pharmacy And Health Sciences
Curated by ChEMBL
Albany College Of Pharmacy And Health Sciences
Curated by ChEMBL
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of recombinant human CYP2C19 expressed in insect cell microsomes in presence of NADPH-regenerating system after 15 to 45 mins by fluoresce...More data for this Ligand-Target Pair
TargetCytochrome P450 2D6(Homo sapiens (Human))
Albany College Of Pharmacy And Health Sciences
Curated by ChEMBL
Albany College Of Pharmacy And Health Sciences
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of recombinant human CYP2D6 expressed in insect cell microsomes in presence of NADPH-regenerating system after 15 to 45 mins by fluorescen...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Albany College Of Pharmacy And Health Sciences
Curated by ChEMBL
Albany College Of Pharmacy And Health Sciences
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human ERG expressed in HEK293 cells at -80 mV holding potential by PatchXpress automated electrophysiology methodMore data for this Ligand-Target Pair
TargetCytochrome P450 2D6(Homo sapiens (Human))
Albany College Of Pharmacy And Health Sciences
Curated by ChEMBL
Albany College Of Pharmacy And Health Sciences
Curated by ChEMBL
Affinity DataIC50: 2.90E+3nMAssay Description:Time dependent inhibition of CYP2D6 in human liver microsomes measured after 30 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetRetinol-binding protein 4(Homo sapiens (Human))
The Trustees Of Columbia University In The City Of New York
US Patent
The Trustees Of Columbia University In The City Of New York
US Patent
Affinity DataIC50: 5.70nMAssay Description:Competitive displacement of 3[H]retinol from biotinylated RBP4 (unknown origin) by surface plasmon resonance analysisMore data for this Ligand-Target Pair
TargetCytochrome P450 2C9(Homo sapiens (Human))
Albany College Of Pharmacy And Health Sciences
Curated by ChEMBL
Albany College Of Pharmacy And Health Sciences
Curated by ChEMBL
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of recombinant human CYP2C9 expressed in insect cell microsomes in presence of NADPH-regenerating system after 15 to 45 mins by fluorescen...More data for this Ligand-Target Pair
TargetCytochrome P450 2D6(Homo sapiens (Human))
Albany College Of Pharmacy And Health Sciences
Curated by ChEMBL
Albany College Of Pharmacy And Health Sciences
Curated by ChEMBL
Affinity DataIC50: 6.10E+4nMAssay Description:Time dependent inhibition of CYP2D6 in human liver microsomes measured after 30 mins in absence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetRetinol-binding protein 4(Homo sapiens (Human))
The Trustees Of Columbia University In The City Of New York
US Patent
The Trustees Of Columbia University In The City Of New York
US Patent
Affinity DataIC50: 4.13nMAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
TargetRetinol-binding protein 4(Homo sapiens (Human))
The Trustees Of Columbia University In The City Of New York
US Patent
The Trustees Of Columbia University In The City Of New York
US Patent
Affinity DataIC50: 5.36nMAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
TargetRetinol-binding protein 4(Homo sapiens (Human))
The Trustees Of Columbia University In The City Of New York
US Patent
The Trustees Of Columbia University In The City Of New York
US Patent
Affinity DataIC50: 5.36nMAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
TargetRetinol-binding protein 4(Homo sapiens (Human))
The Trustees Of Columbia University In The City Of New York
US Patent
The Trustees Of Columbia University In The City Of New York
US Patent
Affinity DataIC50: 5.36nMAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
TargetRetinol-binding protein 4(Homo sapiens (Human))
The Trustees Of Columbia University In The City Of New York
US Patent
The Trustees Of Columbia University In The City Of New York
US Patent
Affinity DataIC50: 4.13nMAssay Description:The analogs of Compounds 63-162 described herein analogously bind to RBP4 and antagonize retinol-dependent RBP4-TTR interaction. Additional piperidin...More data for this Ligand-Target Pair
TargetRetinol-binding protein 4(Homo sapiens (Human))
The Trustees Of Columbia University In The City Of New York
US Patent
The Trustees Of Columbia University In The City Of New York
US Patent
Affinity DataIC50: 12.8nMAssay Description:Binding of a desired RBP4 antagonist displaces retinol and induces hindrance for RBP4-TTR interaction resulting in the decreased FRET signal (FIG. 7 ...More data for this Ligand-Target Pair
TargetRetinol-binding protein 4(Homo sapiens (Human))
The Trustees Of Columbia University In The City Of New York
US Patent
The Trustees Of Columbia University In The City Of New York
US Patent
Affinity DataIC50: 5.36nMAssay Description:The analogs of Compounds 63-162 described herein analogously bind to RBP4 and antagonize retinol-dependent RBP4-TTR interaction. Additional piperidin...More data for this Ligand-Target Pair
TargetRetinol-binding protein 4(Homo sapiens (Human))
The Trustees Of Columbia University In The City Of New York
US Patent
The Trustees Of Columbia University In The City Of New York
US Patent
Affinity DataIC50: 12.7nMAssay Description:Binding of a desired RBP4 antagonist displaces retinol and induces hindrance for RBP4-TTR interaction resulting in the decreased FRET signal (FIG. 7 ...More data for this Ligand-Target Pair
TargetRetinol-binding protein 4(Homo sapiens (Human))
The Trustees Of Columbia University In The City Of New York
US Patent
The Trustees Of Columbia University In The City Of New York
US Patent
Affinity DataIC50: 5.36nMAssay Description:The analogs of Compounds 63-162 described herein analogously bind to RBP4 and antagonize retinol-dependent RBP4-TTR interaction. Additional piperidin...More data for this Ligand-Target Pair
TargetRetinol-binding protein 4(Homo sapiens (Human))
The Trustees Of Columbia University In The City Of New York
US Patent
The Trustees Of Columbia University In The City Of New York
US Patent
Affinity DataIC50: 12.7nMAssay Description:Binding of a desired RBP4 antagonist displaces retinol and induces hindrance for RBP4-TTR interaction resulting in the decreased FRET signal (FIG. 7 ...More data for this Ligand-Target Pair
TargetRetinol-binding protein 4(Homo sapiens (Human))
The Trustees Of Columbia University In The City Of New York
US Patent
The Trustees Of Columbia University In The City Of New York
US Patent
Affinity DataIC50: 5.36nMAssay Description:The analogs of Compounds 63-162 described herein analogously bind to RBP4 and antagonize retinol-dependent RBP4-TTR interaction. Additional piperidin...More data for this Ligand-Target Pair
TargetRetinol-binding protein 4(Homo sapiens (Human))
The Trustees Of Columbia University In The City Of New York
US Patent
The Trustees Of Columbia University In The City Of New York
US Patent
Affinity DataIC50: 4.13nMpH: 7.4 T: 2°CAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
TargetRetinol-binding protein 4(Homo sapiens (Human))
The Trustees Of Columbia University In The City Of New York
US Patent
The Trustees Of Columbia University In The City Of New York
US Patent
Affinity DataIC50: 9.21nMpH: 7.4 T: 2°CAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair