BDBM25150 (2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2-enamide::Belinosta::Belinostat::PXD-101::PXD101

SMILES: c1ccc(cc1)NS(=O)(=O)c2cccc(c2)/C=C/C(=O)NO

InChI Key: InChIKey=NCNRHFGMJRPRSK-UHFFFAOYSA-N

Data: 21 KI  68 IC50  9 EC50  1 Other

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 127 hits for monomerid = 25150   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone deacetylase 1 (Human)	BDBM25150 (Belinostat | (2E)-N-hydroxy-3-[3-(phenylsulfamoyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	18	n/a	n/a	n/a	n/a	8.0	37
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 3 (Human)	BDBM25150 (Belinostat | (2E)-N-hydroxy-3-[3-(phenylsulfamoyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	46	n/a	n/a	n/a	n/a	8.0	37
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 4 [653-1084,H976Y] (Human)	BDBM25150 (Belinostat | (2E)-N-hydroxy-3-[3-(phenylsulfamoyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	24	n/a	n/a	n/a	n/a	7.5	37
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 4 (Human)	BDBM25150 (Belinostat | (2E)-N-hydroxy-3-[3-(phenylsulfamoyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 6 (Human)	BDBM25150 (Belinostat | (2E)-N-hydroxy-3-[3-(phenylsulfamoyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 1 (Human)	BDBM25150 (Belinostat | (2E)-N-hydroxy-3-[3-(phenylsulfamoyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 8 (Human)	BDBM25150 (Belinostat | (2E)-N-hydroxy-3-[3-(phenylsulfamoyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	353	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 4 (Human)	BDBM25150 (Belinostat | (2E)-N-hydroxy-3-[3-(phenylsulfamoyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9.85E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 6 (Human)	BDBM25150 (Belinostat | (2E)-N-hydroxy-3-[3-(phenylsulfamoyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 11 (Human)	BDBM25150 (Belinostat | (2E)-N-hydroxy-3-[3-(phenylsulfamoyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 1 (Human)	BDBM25150 (Belinostat | (2E)-N-hydroxy-3-[3-(phenylsulfamoyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 8 (Human)	BDBM25150 (Belinostat | (2E)-N-hydroxy-3-[3-(phenylsulfamoyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	353	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 4 (Human)	BDBM25150 (Belinostat | (2E)-N-hydroxy-3-[3-(phenylsulfamoyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 6 (Human)	BDBM25150 (Belinostat | (2E)-N-hydroxy-3-[3-(phenylsulfamoyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 11 (Human)	BDBM25150 (Belinostat | (2E)-N-hydroxy-3-[3-(phenylsulfamoyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 6 (Human)	BDBM25150 (Belinostat | (2E)-N-hydroxy-3-[3-(phenylsulfamoyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 8 (Human)	BDBM25150 (Belinostat | (2E)-N-hydroxy-3-[3-(phenylsulfamoyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 1 (Human)	BDBM25150 (Belinostat | (2E)-N-hydroxy-3-[3-(phenylsulfamoyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 2 (Human)	BDBM25150 (Belinostat | (2E)-N-hydroxy-3-[3-(phenylsulfamoyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 4 (Human)	BDBM25150 (Belinostat | (2E)-N-hydroxy-3-[3-(phenylsulfamoyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 (Human)	BDBM25150 (Belinostat | (2E)-N-hydroxy-3-[3-(phenylsulfamoyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase (Plasmodium falciparum (isolate 3D7))	BDBM25150 (Belinostat | (2E)-N-hydroxy-3-[3-(phenylsulfamoyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	215	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase (HDAC1 and HDAC2) (Human)	BDBM25150 (Belinostat | (2E)-N-hydroxy-3-[3-(phenylsulfamoyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 6 (Human)	BDBM25150 (Belinostat | (2E)-N-hydroxy-3-[3-(phenylsulfamoyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 8 (Human)	BDBM25150 (Belinostat | (2E)-N-hydroxy-3-[3-(phenylsulfamoyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	353	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 1 (Human)	BDBM25150 (Belinostat | (2E)-N-hydroxy-3-[3-(phenylsulfamoyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase (Human)	BDBM25150 (Belinostat | (2E)-N-hydroxy-3-[3-(phenylsulfamoyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	30	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase (Human)	BDBM25150 (Belinostat | (2E)-N-hydroxy-3-[3-(phenylsulfamoyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 6 (Human)	BDBM25150 (Belinostat | (2E)-N-hydroxy-3-[3-(phenylsulfamoyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	82	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase (Human)	BDBM25150 (Belinostat | (2E)-N-hydroxy-3-[3-(phenylsulfamoyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 1/2/3/8 (Human)	BDBM25150 (Belinostat | (2E)-N-hydroxy-3-[3-(phenylsulfamoyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	189	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 8 (Human)	BDBM25150 (Belinostat | (2E)-N-hydroxy-3-[3-(phenylsulfamoyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	68	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 6 (Human)	BDBM25150 (Belinostat | (2E)-N-hydroxy-3-[3-(phenylsulfamoyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.43E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 1 (Human)	BDBM25150 (Belinostat | (2E)-N-hydroxy-3-[3-(phenylsulfamoyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase (Human)	BDBM25150 (Belinostat | (2E)-N-hydroxy-3-[3-(phenylsulfamoyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	87	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 8 (Human)	BDBM25150 (Belinostat | (2E)-N-hydroxy-3-[3-(phenylsulfamoyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.53E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aspartyl/asparaginyl beta-hydroxylase (Human)	BDBM25150 (Belinostat | (2E)-N-hydroxy-3-[3-(phenylsulfamoyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.49E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aspartyl/asparaginyl beta-hydroxylase (Human)	BDBM25150 (Belinostat | (2E)-N-hydroxy-3-[3-(phenylsulfamoyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.12E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aspartyl/asparaginyl beta-hydroxylase (Human)	BDBM25150 (Belinostat | (2E)-N-hydroxy-3-[3-(phenylsulfamoyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aspartyl/asparaginyl beta-hydroxylase (Human)	BDBM25150 (Belinostat | (2E)-N-hydroxy-3-[3-(phenylsulfamoyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.77E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 3 (Human)	BDBM25150 (Belinostat | (2E)-N-hydroxy-3-[3-(phenylsulfamoyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 1/2/3/8 (Human)	BDBM25150 (Belinostat | (2E)-N-hydroxy-3-[3-(phenylsulfamoyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	470	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 1/2/3/8 (Human)	BDBM25150 (Belinostat | (2E)-N-hydroxy-3-[3-(phenylsulfamoyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	620	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 1/2/3/8 (Human)	BDBM25150 (Belinostat | (2E)-N-hydroxy-3-[3-(phenylsulfamoyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 1 (Human)	BDBM25150 (Belinostat | (2E)-N-hydroxy-3-[3-(phenylsulfamoyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	41	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 2 (Human)	BDBM25150 (Belinostat | (2E)-N-hydroxy-3-[3-(phenylsulfamoyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	125	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 3 (Human)	BDBM25150 (Belinostat | (2E)-N-hydroxy-3-[3-(phenylsulfamoyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	30	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 4 (Human)	BDBM25150 (Belinostat | (2E)-N-hydroxy-3-[3-(phenylsulfamoyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	115	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 6 (Human)	BDBM25150 (Belinostat | (2E)-N-hydroxy-3-[3-(phenylsulfamoyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	82	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 7 (Human)	BDBM25150 (Belinostat | (2E)-N-hydroxy-3-[3-(phenylsulfamoyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	67	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair