BDBM273241 2-(4-(2-(7,8-dimethyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-3-isopropyl-1H-indol-5-yl) piperidin-1-yl)acetamide::US10071079, Example 15::US10478424, Example 15

SMILES CC(C)c1c([nH]c2ccc(cc12)C1CCN(CC(N)=O)CC1)-c1cn2ncnc2c(C)c1C

InChI Key InChIKey=SNFVHLQYHFQOEP-UHFFFAOYSA-N

Data  6 IC50

Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 273241   

TargetToll-like receptor 7(Homo sapiens (Human))
Bristol-Myers Squibb Co.

US Patent
LigandPNGBDBM273241(2-(4-(2-(7,8-dimethyl-[1,2,4]triazolo[1,5-a]pyridi...)
Show SMILES CC(C)c1c([nH]c2ccc(cc12)C1CCN(CC(N)=O)CC1)-c1cn2ncnc2c(C)c1C
Show InChI InChI=1S/C26H32N6O/c1-15(2)24-20-11-19(18-7-9-31(10-8-18)13-23(27)33)5-6-22(20)30-25(24)21-12-32-26(28-14-29-32)17(4)16(21)3/h5-6,11-12,14-15,18,30H,7-10,13H2,1-4H3,(H2,27,33)
Affinity DataIC50: 1.40nMT: 2°CAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
TargetToll-like receptor 8(Homo sapiens (Human))
Bristol-Myers Squibb Co.

US Patent
LigandPNGBDBM273241(2-(4-(2-(7,8-dimethyl-[1,2,4]triazolo[1,5-a]pyridi...)
Show SMILES CC(C)c1c([nH]c2ccc(cc12)C1CCN(CC(N)=O)CC1)-c1cn2ncnc2c(C)c1C
Show InChI InChI=1S/C26H32N6O/c1-15(2)24-20-11-19(18-7-9-31(10-8-18)13-23(27)33)5-6-22(20)30-25(24)21-12-32-26(28-14-29-32)17(4)16(21)3/h5-6,11-12,14-15,18,30H,7-10,13H2,1-4H3,(H2,27,33)
Affinity DataIC50: 1.40nMT: 2°CAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
TargetToll-like receptor 9(Homo sapiens (Human))
Bristol-Myers Squibb Company

US Patent
LigandPNGBDBM273241(2-(4-(2-(7,8-dimethyl-[1,2,4]triazolo[1,5-a]pyridi...)
Show SMILES CC(C)c1c([nH]c2ccc(cc12)C1CCN(CC(N)=O)CC1)-c1cn2ncnc2c(C)c1C
Show InChI InChI=1S/C26H32N6O/c1-15(2)24-20-11-19(18-7-9-31(10-8-18)13-23(27)33)5-6-22(20)30-25(24)21-12-32-26(28-14-29-32)17(4)16(21)3/h5-6,11-12,14-15,18,30H,7-10,13H2,1-4H3,(H2,27,33)
Affinity DataIC50: 5.11E+3nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
TargetToll-like receptor 7(Homo sapiens (Human))
Bristol-Myers Squibb Co.

US Patent
LigandPNGBDBM273241(2-(4-(2-(7,8-dimethyl-[1,2,4]triazolo[1,5-a]pyridi...)
Show SMILES CC(C)c1c([nH]c2ccc(cc12)C1CCN(CC(N)=O)CC1)-c1cn2ncnc2c(C)c1C
Show InChI InChI=1S/C26H32N6O/c1-15(2)24-20-11-19(18-7-9-31(10-8-18)13-23(27)33)5-6-22(20)30-25(24)21-12-32-26(28-14-29-32)17(4)16(21)3/h5-6,11-12,14-15,18,30H,7-10,13H2,1-4H3,(H2,27,33)
Affinity DataIC50: 1.40nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
TargetToll-like receptor 8(Homo sapiens (Human))
Bristol-Myers Squibb Co.

US Patent
LigandPNGBDBM273241(2-(4-(2-(7,8-dimethyl-[1,2,4]triazolo[1,5-a]pyridi...)
Show SMILES CC(C)c1c([nH]c2ccc(cc12)C1CCN(CC(N)=O)CC1)-c1cn2ncnc2c(C)c1C
Show InChI InChI=1S/C26H32N6O/c1-15(2)24-20-11-19(18-7-9-31(10-8-18)13-23(27)33)5-6-22(20)30-25(24)21-12-32-26(28-14-29-32)17(4)16(21)3/h5-6,11-12,14-15,18,30H,7-10,13H2,1-4H3,(H2,27,33)
Affinity DataIC50: 1.40nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
TargetToll-like receptor 9(Homo sapiens (Human))
Bristol-Myers Squibb Company

US Patent
LigandPNGBDBM273241(2-(4-(2-(7,8-dimethyl-[1,2,4]triazolo[1,5-a]pyridi...)
Show SMILES CC(C)c1c([nH]c2ccc(cc12)C1CCN(CC(N)=O)CC1)-c1cn2ncnc2c(C)c1C
Show InChI InChI=1S/C26H32N6O/c1-15(2)24-20-11-19(18-7-9-31(10-8-18)13-23(27)33)5-6-22(20)30-25(24)21-12-32-26(28-14-29-32)17(4)16(21)3/h5-6,11-12,14-15,18,30H,7-10,13H2,1-4H3,(H2,27,33)
Affinity DataIC50: 5.11E+3nMT: 2°CAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair