BDBM323709 US10188756, Compound CN133::US11207431, Martinostat

SMILES CN(Cc1ccc(\C=C\C(=O)NO)cc1)CC12CC3CC(CC(C3)C1)C2

InChI Key InChIKey=WNIDBXBLQFPAJA-VOTSOKGWSA-N

Data  26 IC50

Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 26 hits for monomerid = 323709   

TargetHistone deacetylase 1(Homo sapiens (Human))
The General Hospital Corporation

US Patent
LigandPNGBDBM323709(US10188756, Compound CN133 | US11207431, Martinost...)
Show SMILES CN(Cc1ccc(\C=C\C(=O)NO)cc1)CC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C22H30N2O2/c1-24(14-17-4-2-16(3-5-17)6-7-21(25)23-26)15-22-11-18-8-19(12-22)10-20(9-18)13-22/h2-7,18-20,26H,8-15H2,1H3,(H,23,25)/b7-6+
Affinity DataIC50: 0.300nMAssay Description:All histone deacetylases were purchased from BPS Bioscience. The substrates, Broad Substrate A, and Broad Substrate B, were synthesized and are now a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetHistone deacetylase 9(Homo sapiens (Human))
The General Hospital Corporation

US Patent
LigandPNGBDBM323709(US10188756, Compound CN133 | US11207431, Martinost...)
Show SMILES CN(Cc1ccc(\C=C\C(=O)NO)cc1)CC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C22H30N2O2/c1-24(14-17-4-2-16(3-5-17)6-7-21(25)23-26)15-22-11-18-8-19(12-22)10-20(9-18)13-22/h2-7,18-20,26H,8-15H2,1H3,(H,23,25)/b7-6+
Affinity DataIC50: 1.00E+3nMAssay Description:IC50 measurements were conducted by BPS Biosciences (Table 1) or by Nanosyn (Table 1A) with an established fluorescence assay. More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetHistone deacetylase 3(Homo sapiens (Human))
The General Hospital Corporation

US Patent
LigandPNGBDBM323709(US10188756, Compound CN133 | US11207431, Martinost...)
Show SMILES CN(Cc1ccc(\C=C\C(=O)NO)cc1)CC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C22H30N2O2/c1-24(14-17-4-2-16(3-5-17)6-7-21(25)23-26)15-22-11-18-8-19(12-22)10-20(9-18)13-22/h2-7,18-20,26H,8-15H2,1H3,(H,23,25)/b7-6+
Affinity DataIC50: 0.600nMAssay Description:All histone deacetylases were purchased from BPS Bioscience. The substrates, Broad Substrate A, and Broad Substrate B, were synthesized and are now a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetHistone deacetylase 4(Homo sapiens (Human))
The General Hospital Corporation

US Patent
LigandPNGBDBM323709(US10188756, Compound CN133 | US11207431, Martinost...)
Show SMILES CN(Cc1ccc(\C=C\C(=O)NO)cc1)CC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C22H30N2O2/c1-24(14-17-4-2-16(3-5-17)6-7-21(25)23-26)15-22-11-18-8-19(12-22)10-20(9-18)13-22/h2-7,18-20,26H,8-15H2,1H3,(H,23,25)/b7-6+
Affinity DataIC50: 1.97E+3nMAssay Description:All histone deacetylases were purchased from BPS Bioscience. The substrates, Broad Substrate A, and Broad Substrate B, were synthesized and are now a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetHistone deacetylase 5(Homo sapiens (Human))
The General Hospital Corporation

US Patent
LigandPNGBDBM323709(US10188756, Compound CN133 | US11207431, Martinost...)
Show SMILES CN(Cc1ccc(\C=C\C(=O)NO)cc1)CC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C22H30N2O2/c1-24(14-17-4-2-16(3-5-17)6-7-21(25)23-26)15-22-11-18-8-19(12-22)10-20(9-18)13-22/h2-7,18-20,26H,8-15H2,1H3,(H,23,25)/b7-6+
Affinity DataIC50: 352nMAssay Description:All histone deacetylases were purchased from BPS Bioscience. The substrates, Broad Substrate A, and Broad Substrate B, were synthesized and are now a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetHistone deacetylase 6(Homo sapiens (Human))
The General Hospital Corporation

US Patent
LigandPNGBDBM323709(US10188756, Compound CN133 | US11207431, Martinost...)
Show SMILES CN(Cc1ccc(\C=C\C(=O)NO)cc1)CC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C22H30N2O2/c1-24(14-17-4-2-16(3-5-17)6-7-21(25)23-26)15-22-11-18-8-19(12-22)10-20(9-18)13-22/h2-7,18-20,26H,8-15H2,1H3,(H,23,25)/b7-6+
Affinity DataIC50: 4.10nMAssay Description:All histone deacetylases were purchased from BPS Bioscience. The substrates, Broad Substrate A, and Broad Substrate B, were synthesized and are now a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetHistone deacetylase 7(Homo sapiens (Human))
The General Hospital Corporation

US Patent
LigandPNGBDBM323709(US10188756, Compound CN133 | US11207431, Martinost...)
Show SMILES CN(Cc1ccc(\C=C\C(=O)NO)cc1)CC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C22H30N2O2/c1-24(14-17-4-2-16(3-5-17)6-7-21(25)23-26)15-22-11-18-8-19(12-22)10-20(9-18)13-22/h2-7,18-20,26H,8-15H2,1H3,(H,23,25)/b7-6+
Affinity DataIC50: 2.00E+4nMAssay Description:All histone deacetylases were purchased from BPS Bioscience. The substrates, Broad Substrate A, and Broad Substrate B, were synthesized and are now a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetHistone deacetylase 8(Homo sapiens (Human))
The General Hospital Corporation

US Patent
LigandPNGBDBM323709(US10188756, Compound CN133 | US11207431, Martinost...)
Show SMILES CN(Cc1ccc(\C=C\C(=O)NO)cc1)CC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C22H30N2O2/c1-24(14-17-4-2-16(3-5-17)6-7-21(25)23-26)15-22-11-18-8-19(12-22)10-20(9-18)13-22/h2-7,18-20,26H,8-15H2,1H3,(H,23,25)/b7-6+
Affinity DataIC50: 1.50E+4nMAssay Description:All histone deacetylases were purchased from BPS Bioscience. The substrates, Broad Substrate A, and Broad Substrate B, were synthesized and are now a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetHistone deacetylase 9(Homo sapiens (Human))
The General Hospital Corporation

US Patent
LigandPNGBDBM323709(US10188756, Compound CN133 | US11207431, Martinost...)
Show SMILES CN(Cc1ccc(\C=C\C(=O)NO)cc1)CC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C22H30N2O2/c1-24(14-17-4-2-16(3-5-17)6-7-21(25)23-26)15-22-11-18-8-19(12-22)10-20(9-18)13-22/h2-7,18-20,26H,8-15H2,1H3,(H,23,25)/b7-6+
Affinity DataIC50: 1.50E+4nMAssay Description:All histone deacetylases were purchased from BPS Bioscience. The substrates, Broad Substrate A, and Broad Substrate B, were synthesized and are now a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetHistone deacetylase 6(Homo sapiens (Human))
The General Hospital Corporation

US Patent
LigandPNGBDBM323709(US10188756, Compound CN133 | US11207431, Martinost...)
Show SMILES CN(Cc1ccc(\C=C\C(=O)NO)cc1)CC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C22H30N2O2/c1-24(14-17-4-2-16(3-5-17)6-7-21(25)23-26)15-22-11-18-8-19(12-22)10-20(9-18)13-22/h2-7,18-20,26H,8-15H2,1H3,(H,23,25)/b7-6+
Affinity DataIC50: 1.80nMAssay Description:IC50 measurements were conducted by BPS Biosciences (Table 1) or by Nanosyn (Table 1A) with an established fluorescence assay. More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPolyamine deacetylase HDAC10(Homo sapiens (Human))
The General Hospital Corporation

US Patent
LigandPNGBDBM323709(US10188756, Compound CN133 | US11207431, Martinost...)
Show SMILES CN(Cc1ccc(\C=C\C(=O)NO)cc1)CC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C22H30N2O2/c1-24(14-17-4-2-16(3-5-17)6-7-21(25)23-26)15-22-11-18-8-19(12-22)10-20(9-18)13-22/h2-7,18-20,26H,8-15H2,1H3,(H,23,25)/b7-6+
Affinity DataIC50: 2nMAssay Description:IC50 measurements were conducted by BPS Biosciences (Table 1) or by Nanosyn (Table 1A) with an established fluorescence assay. More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetHistone deacetylase 11(Homo sapiens (Human))
The General Hospital Corporation

US Patent
LigandPNGBDBM323709(US10188756, Compound CN133 | US11207431, Martinost...)
Show SMILES CN(Cc1ccc(\C=C\C(=O)NO)cc1)CC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C22H30N2O2/c1-24(14-17-4-2-16(3-5-17)6-7-21(25)23-26)15-22-11-18-8-19(12-22)10-20(9-18)13-22/h2-7,18-20,26H,8-15H2,1H3,(H,23,25)/b7-6+
Affinity DataIC50: 1.00E+3nMAssay Description:IC50 measurements were conducted by BPS Biosciences (Table 1) or by Nanosyn (Table 1A) with an established fluorescence assay. More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetHistone deacetylase 1(Homo sapiens (Human))
The General Hospital Corporation

US Patent
LigandPNGBDBM323709(US10188756, Compound CN133 | US11207431, Martinost...)
Show SMILES CN(Cc1ccc(\C=C\C(=O)NO)cc1)CC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C22H30N2O2/c1-24(14-17-4-2-16(3-5-17)6-7-21(25)23-26)15-22-11-18-8-19(12-22)10-20(9-18)13-22/h2-7,18-20,26H,8-15H2,1H3,(H,23,25)/b7-6+
Affinity DataIC50: 6.20nMAssay Description:IC50 measurements were conducted by BPS Biosciences (Table 1) or by Nanosyn (Table 1A) with an established fluorescence assay. More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetHistone deacetylase 2(Homo sapiens (Human))
The General Hospital Corporation

US Patent
LigandPNGBDBM323709(US10188756, Compound CN133 | US11207431, Martinost...)
Show SMILES CN(Cc1ccc(\C=C\C(=O)NO)cc1)CC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C22H30N2O2/c1-24(14-17-4-2-16(3-5-17)6-7-21(25)23-26)15-22-11-18-8-19(12-22)10-20(9-18)13-22/h2-7,18-20,26H,8-15H2,1H3,(H,23,25)/b7-6+
Affinity DataIC50: 22nMAssay Description:IC50 measurements were conducted by BPS Biosciences (Table 1) or by Nanosyn (Table 1A) with an established fluorescence assay. More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetHistone deacetylase 3(Homo sapiens (Human))
The General Hospital Corporation

US Patent
LigandPNGBDBM323709(US10188756, Compound CN133 | US11207431, Martinost...)
Show SMILES CN(Cc1ccc(\C=C\C(=O)NO)cc1)CC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C22H30N2O2/c1-24(14-17-4-2-16(3-5-17)6-7-21(25)23-26)15-22-11-18-8-19(12-22)10-20(9-18)13-22/h2-7,18-20,26H,8-15H2,1H3,(H,23,25)/b7-6+
Affinity DataIC50: 7.10nMAssay Description:IC50 measurements were conducted by BPS Biosciences (Table 1) or by Nanosyn (Table 1A) with an established fluorescence assay. More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetHistone deacetylase 5(Homo sapiens (Human))
The General Hospital Corporation

US Patent
LigandPNGBDBM323709(US10188756, Compound CN133 | US11207431, Martinost...)
Show SMILES CN(Cc1ccc(\C=C\C(=O)NO)cc1)CC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C22H30N2O2/c1-24(14-17-4-2-16(3-5-17)6-7-21(25)23-26)15-22-11-18-8-19(12-22)10-20(9-18)13-22/h2-7,18-20,26H,8-15H2,1H3,(H,23,25)/b7-6+
Affinity DataIC50: 980nMAssay Description:IC50 measurements were conducted by BPS Biosciences (Table 1) or by Nanosyn (Table 1A) with an established fluorescence assay. More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetHistone deacetylase 6(Homo sapiens (Human))
The General Hospital Corporation

US Patent
LigandPNGBDBM323709(US10188756, Compound CN133 | US11207431, Martinost...)
Show SMILES CN(Cc1ccc(\C=C\C(=O)NO)cc1)CC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C22H30N2O2/c1-24(14-17-4-2-16(3-5-17)6-7-21(25)23-26)15-22-11-18-8-19(12-22)10-20(9-18)13-22/h2-7,18-20,26H,8-15H2,1H3,(H,23,25)/b7-6+
Affinity DataIC50: 48nMAssay Description:IC50 measurements were conducted by BPS Biosciences (Table 1) or by Nanosyn (Table 1A) with an established fluorescence assay. More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPolyamine deacetylase HDAC10(Homo sapiens (Human))
The General Hospital Corporation

US Patent
LigandPNGBDBM323709(US10188756, Compound CN133 | US11207431, Martinost...)
Show SMILES CN(Cc1ccc(\C=C\C(=O)NO)cc1)CC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C22H30N2O2/c1-24(14-17-4-2-16(3-5-17)6-7-21(25)23-26)15-22-11-18-8-19(12-22)10-20(9-18)13-22/h2-7,18-20,26H,8-15H2,1H3,(H,23,25)/b7-6+
Affinity DataIC50: 8.90nMAssay Description:IC50 measurements were conducted by BPS Biosciences (Table 1) or by Nanosyn (Table 1A) with an established fluorescence assay. More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetHistone deacetylase 1(Homo sapiens (Human))
The General Hospital Corporation

US Patent
LigandPNGBDBM323709(US10188756, Compound CN133 | US11207431, Martinost...)
Show SMILES CN(Cc1ccc(\C=C\C(=O)NO)cc1)CC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C22H30N2O2/c1-24(14-17-4-2-16(3-5-17)6-7-21(25)23-26)15-22-11-18-8-19(12-22)10-20(9-18)13-22/h2-7,18-20,26H,8-15H2,1H3,(H,23,25)/b7-6+
Affinity DataIC50: 1.20nMAssay Description:IC50 measurements were conducted by BPS Biosciences (Table 1) or by Nanosyn (Table 1A) with an established fluorescence assay. More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetHistone deacetylase 2(Homo sapiens (Human))
The General Hospital Corporation

US Patent
LigandPNGBDBM323709(US10188756, Compound CN133 | US11207431, Martinost...)
Show SMILES CN(Cc1ccc(\C=C\C(=O)NO)cc1)CC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C22H30N2O2/c1-24(14-17-4-2-16(3-5-17)6-7-21(25)23-26)15-22-11-18-8-19(12-22)10-20(9-18)13-22/h2-7,18-20,26H,8-15H2,1H3,(H,23,25)/b7-6+
Affinity DataIC50: 4nMAssay Description:IC50 measurements were conducted by BPS Biosciences (Table 1) or by Nanosyn (Table 1A) with an established fluorescence assay. More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetHistone deacetylase 3(Homo sapiens (Human))
The General Hospital Corporation

US Patent
LigandPNGBDBM323709(US10188756, Compound CN133 | US11207431, Martinost...)
Show SMILES CN(Cc1ccc(\C=C\C(=O)NO)cc1)CC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C22H30N2O2/c1-24(14-17-4-2-16(3-5-17)6-7-21(25)23-26)15-22-11-18-8-19(12-22)10-20(9-18)13-22/h2-7,18-20,26H,8-15H2,1H3,(H,23,25)/b7-6+
Affinity DataIC50: 0.300nMAssay Description:IC50 measurements were conducted by BPS Biosciences (Table 1) or by Nanosyn (Table 1A) with an established fluorescence assay. More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetHistone deacetylase 8(Homo sapiens (Human))
The General Hospital Corporation

US Patent
LigandPNGBDBM323709(US10188756, Compound CN133 | US11207431, Martinost...)
Show SMILES CN(Cc1ccc(\C=C\C(=O)NO)cc1)CC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C22H30N2O2/c1-24(14-17-4-2-16(3-5-17)6-7-21(25)23-26)15-22-11-18-8-19(12-22)10-20(9-18)13-22/h2-7,18-20,26H,8-15H2,1H3,(H,23,25)/b7-6+
Affinity DataIC50: 750nMAssay Description:IC50 measurements were conducted by BPS Biosciences (Table 1) or by Nanosyn (Table 1A) with an established fluorescence assay. More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetHistone deacetylase 4(Homo sapiens (Human))
The General Hospital Corporation

US Patent
LigandPNGBDBM323709(US10188756, Compound CN133 | US11207431, Martinost...)
Show SMILES CN(Cc1ccc(\C=C\C(=O)NO)cc1)CC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C22H30N2O2/c1-24(14-17-4-2-16(3-5-17)6-7-21(25)23-26)15-22-11-18-8-19(12-22)10-20(9-18)13-22/h2-7,18-20,26H,8-15H2,1H3,(H,23,25)/b7-6+
Affinity DataIC50: 240nMAssay Description:IC50 measurements were conducted by BPS Biosciences (Table 1) or by Nanosyn (Table 1A) with an established fluorescence assay. More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetHistone deacetylase 5(Homo sapiens (Human))
The General Hospital Corporation

US Patent
LigandPNGBDBM323709(US10188756, Compound CN133 | US11207431, Martinost...)
Show SMILES CN(Cc1ccc(\C=C\C(=O)NO)cc1)CC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C22H30N2O2/c1-24(14-17-4-2-16(3-5-17)6-7-21(25)23-26)15-22-11-18-8-19(12-22)10-20(9-18)13-22/h2-7,18-20,26H,8-15H2,1H3,(H,23,25)/b7-6+
Affinity DataIC50: 75nMAssay Description:IC50 measurements were conducted by BPS Biosciences (Table 1) or by Nanosyn (Table 1A) with an established fluorescence assay. More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetHistone deacetylase 7(Homo sapiens (Human))
The General Hospital Corporation

US Patent
LigandPNGBDBM323709(US10188756, Compound CN133 | US11207431, Martinost...)
Show SMILES CN(Cc1ccc(\C=C\C(=O)NO)cc1)CC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C22H30N2O2/c1-24(14-17-4-2-16(3-5-17)6-7-21(25)23-26)15-22-11-18-8-19(12-22)10-20(9-18)13-22/h2-7,18-20,26H,8-15H2,1H3,(H,23,25)/b7-6+
Affinity DataIC50: 1.00E+3nMAssay Description:IC50 measurements were conducted by BPS Biosciences (Table 1) or by Nanosyn (Table 1A) with an established fluorescence assay. More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetHistone deacetylase 2(Homo sapiens (Human))
The General Hospital Corporation

US Patent
LigandPNGBDBM323709(US10188756, Compound CN133 | US11207431, Martinost...)
Show SMILES CN(Cc1ccc(\C=C\C(=O)NO)cc1)CC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C22H30N2O2/c1-24(14-17-4-2-16(3-5-17)6-7-21(25)23-26)15-22-11-18-8-19(12-22)10-20(9-18)13-22/h2-7,18-20,26H,8-15H2,1H3,(H,23,25)/b7-6+
Affinity DataIC50: 0.800nMAssay Description:All histone deacetylases were purchased from BPS Bioscience. The substrates, Broad Substrate A, and Broad Substrate B, were synthesized and are now a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid