BDBM50003359 5-(4-Hexyloxy-[1,2,5]thiadiazol-3-yl)-1-methyl-1,2,3,6-tetrahydro-pyridine; oxalic acid::5-[4-(hexyloxy)-1,2,5-thiadiazol-3-yl]-1-methyl-1,2,3,6-tetrahydropyridine::CHEMBL21536::CHEMBL73149::LY 246708::Xanomeline

SMILES: CCCCCCOc1c(nsn1)C2=CCCN(C2)C

InChI Key: InChIKey=JOLJIIDDOBNFHW-UHFFFAOYSA-N

Data: 41 KI  24 IC50  23 EC50

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 88 hits for monomerid = 50003359   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Muscarinic acetylcholine receptor M1 (Mouse)	BDBM50003359 (CHEMBL73149 | LY 246708 | CHEMBL21536 | 5-(4-Hexyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	5.70E+3	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (Human)	BDBM50003359 (CHEMBL73149 | LY 246708 | CHEMBL21536 | 5-(4-Hexyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	6.20	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Human)	BDBM50003359 (CHEMBL73149 | LY 246708 | CHEMBL21536 | 5-(4-Hexyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	1.60	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M5 (Human)	BDBM50003359 (CHEMBL73149 | LY 246708 | CHEMBL21536 | 5-(4-Hexyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	140	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M3 (Human)	BDBM50003359 (CHEMBL73149 | LY 246708 | CHEMBL21536 | 5-(4-Hexyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	120	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (Human)	BDBM50003359 (CHEMBL73149 | LY 246708 | CHEMBL21536 | 5-(4-Hexyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	398	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Human)	BDBM50003359 (CHEMBL73149 | LY 246708 | CHEMBL21536 | 5-(4-Hexyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	135	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (Rat)	BDBM50003359 (CHEMBL73149 | LY 246708 | CHEMBL21536 | 5-(4-Hexyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M3 (Mouse)	BDBM50003359 (CHEMBL73149 | LY 246708 | CHEMBL21536 | 5-(4-Hexyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	1.10E+4	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (Human)	BDBM50003359 (CHEMBL73149 | LY 246708 | CHEMBL21536 | 5-(4-Hexyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Rat)	BDBM50003359 (CHEMBL73149 | LY 246708 | CHEMBL21536 | 5-(4-Hexyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Rat)	BDBM50003359 (CHEMBL73149 | LY 246708 | CHEMBL21536 | 5-(4-Hexyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5 (Rat)	BDBM50003359 (CHEMBL73149 | LY 246708 | CHEMBL21536 | 5-(4-Hexyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Rat)	BDBM50003359 (CHEMBL73149 | LY 246708 | CHEMBL21536 | 5-(4-Hexyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Rat)	BDBM50003359 (CHEMBL73149 | LY 246708 | CHEMBL21536 | 5-(4-Hexyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5 (Rat)	BDBM50003359 (CHEMBL73149 | LY 246708 | CHEMBL21536 | 5-(4-Hexyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Human)	BDBM50003359 (CHEMBL73149 | LY 246708 | CHEMBL21536 | 5-(4-Hexyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	57	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Human)	BDBM50003359 (CHEMBL73149 | LY 246708 | CHEMBL21536 | 5-(4-Hexyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	2.60E+3	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (Human)	BDBM50003359 (CHEMBL73149 | LY 246708 | CHEMBL21536 | 5-(4-Hexyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	16	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M5 (Human)	BDBM50003359 (CHEMBL73149 | LY 246708 | CHEMBL21536 | 5-(4-Hexyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	142	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (Human)	BDBM50003359 (CHEMBL73149 | LY 246708 | CHEMBL21536 | 5-(4-Hexyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	229	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (Human)	BDBM50003359 (CHEMBL73149 | LY 246708 | CHEMBL21536 | 5-(4-Hexyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	121	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Human)	BDBM50003359 (CHEMBL73149 | LY 246708 | CHEMBL21536 | 5-(4-Hexyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	67	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Human)	BDBM50003359 (CHEMBL73149 | LY 246708 | CHEMBL21536 | 5-(4-Hexyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	1.62E+4	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Human)	BDBM50003359 (CHEMBL73149 | LY 246708 | CHEMBL21536 | 5-(4-Hexyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	13	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Human)	BDBM50003359 (CHEMBL73149 | LY 246708 | CHEMBL21536 | 5-(4-Hexyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	16	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (Human)	BDBM50003359 (CHEMBL73149 | LY 246708 | CHEMBL21536 | 5-(4-Hexyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	186	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Rat)	BDBM50003359 (CHEMBL73149 | LY 246708 | CHEMBL21536 | 5-(4-Hexyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (Human)	BDBM50003359 (CHEMBL73149 | LY 246708 | CHEMBL21536 | 5-(4-Hexyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	6.31E+3	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Human)	BDBM50003359 (CHEMBL73149 | LY 246708 | CHEMBL21536 | 5-(4-Hexyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	81	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Human)	BDBM50003359 (CHEMBL73149 | LY 246708 | CHEMBL21536 | 5-(4-Hexyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	18	n/a	n/a	n/a	n/a	6.0	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Human)	BDBM50003359 (CHEMBL73149 | LY 246708 | CHEMBL21536 | 5-(4-Hexyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	955	n/a	n/a	n/a	n/a	8.0	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Human)	BDBM50003359 (CHEMBL73149 | LY 246708 | CHEMBL21536 | 5-(4-Hexyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	6.0	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Human)	BDBM50003359 (CHEMBL73149 | LY 246708 | CHEMBL21536 | 5-(4-Hexyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	29	n/a	n/a	n/a	n/a	8.0	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Human)	BDBM50003359 (CHEMBL73149 | LY 246708 | CHEMBL21536 | 5-(4-Hexyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (Human)	BDBM50003359 (CHEMBL73149 | LY 246708 | CHEMBL21536 | 5-(4-Hexyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (Human)	BDBM50003359 (CHEMBL73149 | LY 246708 | CHEMBL21536 | 5-(4-Hexyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	316	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Rat)	BDBM50003359 (CHEMBL73149 | LY 246708 | CHEMBL21536 | 5-(4-Hexyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Rat)	BDBM50003359 (CHEMBL73149 | LY 246708 | CHEMBL21536 | 5-(4-Hexyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (Human)	BDBM50003359 (CHEMBL73149 | LY 246708 | CHEMBL21536 | 5-(4-Hexyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	6	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Rat)	BDBM50003359 (CHEMBL73149 | LY 246708 | CHEMBL21536 | 5-(4-Hexyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (Human)	BDBM50003359 (CHEMBL73149 | LY 246708 | CHEMBL21536 | 5-(4-Hexyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	18	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Rat)	BDBM50003359 (CHEMBL73149 | LY 246708 | CHEMBL21536 | 5-(4-Hexyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Human)	BDBM50003359 (CHEMBL73149 | LY 246708 | CHEMBL21536 | 5-(4-Hexyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.00800	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Rat)	BDBM50003359 (CHEMBL73149 | LY 246708 | CHEMBL21536 | 5-(4-Hexyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Human)	BDBM50003359 (CHEMBL73149 | LY 246708 | CHEMBL21536 | 5-(4-Hexyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	200	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Rat)	BDBM50003359 (CHEMBL73149 | LY 246708 | CHEMBL21536 | 5-(4-Hexyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1D (Human)	BDBM50003359 (CHEMBL73149 | LY 246708 | CHEMBL21536 | 5-(4-Hexyl...) Show SMILES Show InChI	GoogleScholar	UniChem		6.31	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M3 (Human)	BDBM50003359 (CHEMBL73149 | LY 246708 | CHEMBL21536 | 5-(4-Hexyl...) Show SMILES Show InChI	GoogleScholar	UniChem		7.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Human)	BDBM50003359 (CHEMBL73149 | LY 246708 | CHEMBL21536 | 5-(4-Hexyl...) Show SMILES Show InChI	GoogleScholar	UniChem		7.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair