Found 94 hits for monomerid = 50016897 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Alpha-1A adrenergic receptor
(Homo sapiens (Human)) | BDBM50016897
 (2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)Show InChI InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14) | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar
| Purchase
CHEBI PC cid PC sid PDB UniChem
Patents
Similars
| PubMed
| 316 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Centre de Recherches de Croissy
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 295: 1192-205 (2000)
BindingDB Entry DOI: 10.7270/Q28P5Z2C |
More data for this Ligand-Target Pair | |
Alpha adrenergic receptor 1A and 1B
(Rattus norvegicus (rat)) | BDBM50016897
 (2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)Show InChI InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14) | Reactome pathway
UniProtKB/SwissProt
GoogleScholar
| Purchase
CHEBI PC cid PC sid PDB UniChem
Patents
Similars
| PubMed
| 316 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Centre de Recherches de Croissy
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 295: 1192-205 (2000)
BindingDB Entry DOI: 10.7270/Q28P5Z2C |
More data for this Ligand-Target Pair | |
Adrenergic alpha1B
(Homo sapiens (Human)) | BDBM50016897
 (2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)Show InChI InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14) | Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar
| Purchase
CHEBI PC cid PC sid PDB UniChem
Patents
Similars
| PubMed
| 316 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Centre de Recherches de Croissy
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 295: 1192-205 (2000)
BindingDB Entry DOI: 10.7270/Q28P5Z2C |
More data for this Ligand-Target Pair | |
Alpha-1A adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM50016897
 (2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)Show InChI InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14) | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar
| Purchase
CHEBI PC cid PC sid PDB UniChem
Patents
Similars
| PubMed
| 430 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by PDSP Ki Database
| |
Mol Pharmacol 13: 454-73 (1977)
BindingDB Entry DOI: 10.7270/Q2TT4PFZ |
More data for this Ligand-Target Pair | |
Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM50016897
 (2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)Show InChI InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14) | PDB
Reactome pathway
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia GoogleScholar
| Purchase
CHEBI PC cid PC sid PDB UniChem
Patents
Similars
| PubMed
| 501 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Centre de Recherches de Croissy
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 295: 1192-205 (2000)
BindingDB Entry DOI: 10.7270/Q28P5Z2C |
More data for this Ligand-Target Pair | |
Alpha-1A adrenergic receptor
(Homo sapiens (Human)) | BDBM50016897
 (2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)Show InChI InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14) | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar
| Purchase
CHEBI PC cid PC sid PDB UniChem
Patents
Similars
| | 513 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Binding affinity towards human Alpha-1A adrenergic receptor by the displacement of [3H]prazosin |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2GQ70ZD |
More data for this Ligand-Target Pair | |
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor
(Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50016897
 (2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)Show InChI InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14) | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar
| Purchase
CHEBI PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| 528 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Compound was tested for the inhibition of [3H]prazosin binding Alpha-1 adrenergic receptor of crude rat brain membrane. |
J Med Chem 25: 75-81 (1982)
Article DOI: 10.1021/jm00343a015 BindingDB Entry DOI: 10.7270/Q2TM7DBC |
More data for this Ligand-Target Pair | |
Serotonin (5-HT) receptor
(Rattus norvegicus (rat)) | BDBM50016897
 (2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)Show InChI InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14) | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar
| Purchase
CHEBI PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| 580 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by PDSP Ki Database
| |
Life Sci 19: 69-76 (1976)
Article DOI: 10.1016/0024-3205(76)90375-1 BindingDB Entry DOI: 10.7270/Q23B5XNK |
More data for this Ligand-Target Pair | |
Alpha-2A adrenergic receptor
(Rattus norvegicus (rat)) | BDBM50016897
 (2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)Show InChI InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar
| Purchase
CHEBI PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| 853 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description in vitro alpha-2A adrenergic receptor binding assay from rats ,using RX 821002 as the displaceable ligand |
J Med Chem 43: 1423-6 (2001)
Article DOI: 10.1021/jm000128r BindingDB Entry DOI: 10.7270/Q2C828HK |
More data for this Ligand-Target Pair | |
Alpha-2A adrenergic receptor
(Homo sapiens (Human)) | BDBM50016897
 (2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)Show InChI InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14) | PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar
| Purchase
CHEBI PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| 853 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Binding affinity towards Alpha-2A adrenergic receptor |
J Med Chem 43: 765-8 (2000)
Article DOI: 10.1021/jm990569e BindingDB Entry DOI: 10.7270/Q2251HDX |
More data for this Ligand-Target Pair | |
Alpha-1A adrenergic receptor
(Homo sapiens (Human)) | BDBM50016897
 (2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)Show InChI InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14) | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar
| Purchase
CHEBI PC cid PC sid PDB UniChem
Patents
Similars
| | 977 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Binding affinity towards human Alpha-1C adrenergic receptor by the displacement of [3H]prazosin |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2GQ70ZD |
More data for this Ligand-Target Pair | |
Monoamine Oxidase Type B (MAO-B)
(Rattus norvegicus (rat)) | BDBM50016897
 (2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)Show InChI InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar
| Purchase
CHEBI PC cid PC sid PDB UniChem
Patents
Similars
| PubMed
| 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Centre de Recherches de Croissy
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 295: 1192-205 (2000)
BindingDB Entry DOI: 10.7270/Q28P5Z2C |
More data for this Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50016897
 (2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)Show InChI InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14) | Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia GoogleScholar
| Purchase
CHEBI PC cid PC sid PDB UniChem
Patents
Similars
| PubMed
| 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Centre de Recherches de Croissy
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 295: 1192-205 (2000)
BindingDB Entry DOI: 10.7270/Q28P5Z2C |
More data for this Ligand-Target Pair | |
Monoamine oxidase
(Rattus norvegicus (rat)) | BDBM50016897
 (2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)Show InChI InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14) | PDB MMDB
Reactome pathway
UniProtKB/SwissProt
DrugBank GoogleScholar
| Purchase
CHEBI PC cid PC sid PDB UniChem
Patents
Similars
| PubMed
| 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Centre de Recherches de Croissy
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 295: 1192-205 (2000)
BindingDB Entry DOI: 10.7270/Q28P5Z2C |
More data for this Ligand-Target Pair | |
Imidazoline I1
(RAT) | BDBM50016897
 (2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)Show InChI InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14) | UniProtKB/SwissProt
GoogleScholar
| Purchase
CHEBI PC cid PC sid PDB UniChem
Patents
Similars
| PubMed
| 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Centre de Recherches de Croissy
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 295: 1192-205 (2000)
BindingDB Entry DOI: 10.7270/Q28P5Z2C |
More data for this Ligand-Target Pair | |
Adrenaline alpha1
(RAT) | BDBM50016897
 (2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)Show InChI InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14) | Reactome pathway
UniProtKB/SwissProt
GoogleScholar
| Purchase
CHEBI PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Heidelberg
Curated by ChEMBL
| Assay Description TP_TRANSPORTER: inhibition of MPP+ uptake in OCT1-expressing HEK293 cells |
Naunyn Schmiedebergs Arch Pharmacol 354: 320-6 (1997)
Article DOI: 10.1007/bf00171063 BindingDB Entry DOI: 10.7270/Q2MG7QSP |
More data for this Ligand-Target Pair | |
D(2) dopamine receptor
(Rattus norvegicus (rat)) | BDBM50016897
 (2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)Show InChI InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar
| Purchase
CHEBI PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| 1.98E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toronto
Curated by PDSP Ki Database
| |
Synapse 25: 137-46 (1997)
Article DOI: 10.1002/(SICI)1098-2396(199702)25:2 BindingDB Entry DOI: 10.7270/Q2WH2NH6 |
More data for this Ligand-Target Pair | |
adrenergic Alpha2
(RAT) | BDBM50016897
 (2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)Show InChI InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar
| Purchase
CHEBI PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| 2.07E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NIDA Addiction Research Center
Curated by PDSP Ki Database
| |
Life Sci 45: 1821-9 (1989)
Article DOI: 10.1016/0024-3205(89)90523-7 BindingDB Entry DOI: 10.7270/Q20Z71SN |
More data for this Ligand-Target Pair | |
Adrenergic alpha1B
(Homo sapiens (Human)) | BDBM50016897
 (2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)Show InChI InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14) | Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar
| Purchase
CHEBI PC cid PC sid PDB UniChem
Patents
Similars
| | 2.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Binding affinity towards human Alpha-1B adrenergic receptor by the displacement of [3H]prazosin |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2GQ70ZD |
More data for this Ligand-Target Pair | |
Imidazoline I1
(RAT) | BDBM50016897
 (2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)Show InChI InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14) | UniProtKB/SwissProt
GoogleScholar
| Purchase
CHEBI PC cid PC sid PDB UniChem
Patents
Similars
| PubMed
| 2.52E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Bonn
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 285: 170-7 (1998)
BindingDB Entry DOI: 10.7270/Q27H1H4B |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human)) | BDBM50016897
 (2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)Show InChI InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14) | PDB
Reactome pathway
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia GoogleScholar
| Purchase
CHEBI PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| 3.24E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in HeLa cells after 30 mins |
ACS Med Chem Lett 3: 535-539 (2012)
Article DOI: 10.1021/ml300064v BindingDB Entry DOI: 10.7270/Q28W3FK6 |
More data for this Ligand-Target Pair | |
D(2) dopamine receptor
(Rattus norvegicus (rat)) | BDBM50016897
 (2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)Show InChI InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar
| Purchase
CHEBI PC cid PC sid PDB UniChem
Patents
Similars
| PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Department of Veterans Affairs Medical Center
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 252: 1108-16 (1990)
BindingDB Entry DOI: 10.7270/Q2TD9VV5 |
More data for this Ligand-Target Pair | |
Imidazoline I1
(RAT) | BDBM50016897
 (2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)Show InChI InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14) | UniProtKB/SwissProt
GoogleScholar
| Purchase
CHEBI PC cid PC sid PDB UniChem
Patents
Similars
| PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Bonn
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 285: 170-7 (1998)
BindingDB Entry DOI: 10.7270/Q27H1H4B |
More data for this Ligand-Target Pair | |
Serotonin 1B/1D receptor
(Rattus norvegicus (Rat)) | BDBM50016897
 (2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)Show InChI InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar
| Purchase
CHEBI PC cid PC sid PDB UniChem
Patents
Similars
| PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 260: 614-26 (1992)
BindingDB Entry DOI: 10.7270/Q2SJ1J3M |
More data for this Ligand-Target Pair | |
Sigma non-opioid intracellular receptor 1
(Cavia porcellus (Guinea pig)) | BDBM50016897
 (2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)Show InChI InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14) | PDB
UniProtKB/SwissProt
GoogleScholar
| Purchase
CHEBI PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by PDSP Ki Database
| |
J Pharm Pharmacol 38: 374-9 (1986)
Article DOI: 10.1111/j.2042-7158.1986.tb04590.x BindingDB Entry DOI: 10.7270/Q2JS9NXW |
More data for this Ligand-Target Pair | |
Vascular adhesion protein 1 (VAP-1)
(Rattus norvegicus (Rat)) | BDBM50016897
 (2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)Show InChI InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14) | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar
| Purchase
CHEBI PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| 9.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Technology
Curated by ChEMBL
| Assay Description Inhibitory activity of the compound against porcine kidney amine oxidase |
Bioorg Med Chem Lett 11: 2565-8 (2001)
Article DOI: 10.1016/s0960-894x(01)00506-6 BindingDB Entry DOI: 10.7270/Q25T3JR2 |
More data for this Ligand-Target Pair | |
Solute carrier family 22 member 3
(Homo sapiens (Human)) | BDBM50016897
 (2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)Show InChI InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14) | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar
| Purchase
CHEBI PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 7.93E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidade do Porto
Curated by ChEMBL
| Assay Description TP_TRANSPORTER: inhibition of MPP+ uptake (MPP+: 0.2 uM) in OCT3-expressing HEK293 cells |
Naunyn Schmiedebergs Arch Pharmacol 363: 40-9 (2001)
Article DOI: 10.1007/s002100000335 BindingDB Entry DOI: 10.7270/Q2GQ702R |
More data for this Ligand-Target Pair | |
Multidrug and toxin extrusion protein 1
(Homo sapiens (Human)) | BDBM50016897
 (2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)Show InChI InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14) | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar
| Purchase
CHEBI PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 3.33E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California
Curated by ChEMBL
| Assay Description Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay |
J Med Chem 56: 781-95 (2013)
Article DOI: 10.1021/jm301302s BindingDB Entry DOI: 10.7270/Q2F76DWZ |
More data for this Ligand-Target Pair | |
Adrenergic Alpha
(Homo sapiens (Human)) | BDBM50016897
 (2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)Show InChI InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14) | Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar
| Purchase
CHEBI PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2.26E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Uppsala University
Curated by ChEMBL
| Assay Description Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells by confocal microscopy |
J Med Chem 51: 5932-42 (2008)
Article DOI: 10.1021/jm8003152 BindingDB Entry DOI: 10.7270/Q23779MD |
More data for this Ligand-Target Pair | |
Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM50016897
 (2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)Show InChI InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14) | PDB
Reactome pathway
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia GoogleScholar
| Purchase
CHEBI PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 58 | n/a | n/a | n/a | n/a |
Universita` di Camerino
Curated by ChEMBL
| Assay Description Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry |
J Med Chem 53: 7825-35 (2010)
Article DOI: 10.1021/jm100977d BindingDB Entry DOI: 10.7270/Q24B32JF |
More data for this Ligand-Target Pair | |
Alpha-2A adrenergic receptor
(Homo sapiens (Human)) | BDBM50016897
 (2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)Show InChI InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14) | PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar
| Purchase
CHEBI PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 8.30 | n/a | n/a | n/a | n/a |
Universita` di Camerino
Curated by ChEMBL
| Assay Description Agonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry |
J Med Chem 53: 7825-35 (2010)
Article DOI: 10.1021/jm100977d BindingDB Entry DOI: 10.7270/Q24B32JF |
More data for this Ligand-Target Pair | |
Alpha-1A adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM50016897
 (2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)Show InChI InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14) | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar
| Purchase
CHEBI PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | 257 | n/a | n/a | n/a | n/a | n/a |
Institut de Pharmacologie (UA 589 CNRS)
Curated by ChEMBL
| Assay Description The compound was tested for alpha-adrenergic activity against Alpha-1 adrenergic receptor from rat aorta. |
J Med Chem 34: 3197-204 (1991)
Article DOI: 10.1021/jm00115a008 BindingDB Entry DOI: 10.7270/Q2NS0W3J |
More data for this Ligand-Target Pair | |
Alpha-2B adrenergic receptor
(Homo sapiens (Human)) | BDBM50016897
 (2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)Show InChI InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14) | PDB
Reactome pathway
UniProtKB/SwissProt
GoogleScholar
| Purchase
CHEBI PC cid PC sid PDB UniChem
Patents
Similars
| | n/a | n/a | n/a | n/a | 166 | n/a | n/a | n/a | n/a |
TBA
| Assay Description Agonistic activity towards human Alpha-2B adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine m... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2GQ70ZD |
More data for this Ligand-Target Pair | |
Alpha-2A adrenergic receptor
(Homo sapiens (Human)) | BDBM50016897
 (2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)Show InChI InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14) | PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar
| Purchase
CHEBI PC cid PC sid PDB UniChem
Patents
Similars
| | n/a | n/a | n/a | n/a | 8.10 | n/a | n/a | n/a | n/a |
TBA
| Assay Description Agonistic activity towards human Alpha-2A adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine m... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2GQ70ZD |
More data for this Ligand-Target Pair | |
Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM50016897
 (2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)Show InChI InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14) | PDB
Reactome pathway
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia GoogleScholar
| Purchase
CHEBI PC cid PC sid PDB UniChem
Patents
Similars
| | n/a | n/a | n/a | n/a | 55 | n/a | n/a | n/a | n/a |
TBA
| Assay Description Agonistic activity towards human Alpha-2C adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine m... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2GQ70ZD |
More data for this Ligand-Target Pair | |
Alpha-2A adrenergic receptor
(Homo sapiens (Human)) | BDBM50016897
 (2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)Show InChI InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14) | PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar
| Purchase
CHEBI PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 30 | n/a | n/a | n/a | n/a |
Medical University of Gdansk
Curated by ChEMBL
| Assay Description Agonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintill... |
Bioorg Med Chem 20: 108-16 (2011)
Article DOI: 10.1016/j.bmc.2011.11.025 BindingDB Entry DOI: 10.7270/Q2DJ5G10 |
More data for this Ligand-Target Pair | |
Imidazoline I1
(RAT) | BDBM50016897
 (2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)Show InChI InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14) | UniProtKB/SwissProt
GoogleScholar
| Purchase
CHEBI PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 366 | n/a | n/a | n/a | n/a | n/a | n/a |
Gdansk University of Technology
Curated by ChEMBL
| Assay Description Inhibition of Sprague-Dawley rat imidazoline I1 receptor |
Bioorg Med Chem 19: 156-67 (2011)
Article DOI: 10.1016/j.bmc.2010.11.039 BindingDB Entry DOI: 10.7270/Q2GH9J79 |
More data for this Ligand-Target Pair | |
Alpha-2A adrenergic receptor
(Homo sapiens (Human)) | BDBM50016897
 (2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)Show InChI InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14) | PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar
| Purchase
CHEBI PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 28 | n/a | n/a | n/a | n/a |
Medical University of Gdansk
Curated by ChEMBL
| Assay Description Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 min... |
Bioorg Med Chem 19: 321-9 (2011)
Article DOI: 10.1016/j.bmc.2010.11.020 BindingDB Entry DOI: 10.7270/Q2FQ9WX5 |
More data for this Ligand-Target Pair | |
Alpha-2A adrenergic receptor
(Homo sapiens (Human)) | BDBM50016897
 (2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)Show InChI InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14) | PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar
| Purchase
CHEBI PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 30 | n/a | n/a | n/a | n/a |
University of Belgrade
Curated by ChEMBL
| Assay Description Agonist activity at recombinant human alpha2A adrenoreceptor expressed in CHOK1 cell membrane incubated for 30 mins by [35S]GTPgammaS binding assay |
Bioorg Med Chem 24: 3174-83 (2016)
Article DOI: 10.1016/j.bmc.2016.05.043 BindingDB Entry DOI: 10.7270/Q2NZ89J3 |
More data for this Ligand-Target Pair | |
Imidazoline I1
(RAT) | BDBM50016897
 (2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)Show InChI InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14) | UniProtKB/SwissProt
GoogleScholar
| Purchase
CHEBI PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 366 | n/a | n/a | n/a | n/a | n/a | n/a |
Gda£?sk University of Technology
Curated by ChEMBL
| Assay Description Displacement of [3H]clonidine from imidazoline I1 receptor in Sprague-Dawley rat kidney by liquid scintillation counting |
Bioorg Med Chem Lett 19: 1009-11 (2009)
Article DOI: 10.1016/j.bmcl.2008.11.055 BindingDB Entry DOI: 10.7270/Q2125SJ6 |
More data for this Ligand-Target Pair | |
Alpha-2B adrenergic receptor
(Homo sapiens (Human)) | BDBM50016897
 (2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)Show InChI InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14) | PDB
Reactome pathway
UniProtKB/SwissProt
GoogleScholar
| Purchase
CHEBI PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 1.18E+3 | n/a | n/a | n/a | n/a |
Universita` di Camerino
Curated by ChEMBL
| Assay Description Agonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry |
J Med Chem 53: 7825-35 (2010)
Article DOI: 10.1021/jm100977d BindingDB Entry DOI: 10.7270/Q24B32JF |
More data for this Ligand-Target Pair | |
adrenergic Alpha2
(BOVINE) | BDBM50016897
 (2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)Show InChI InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14) | PDB
KEGG
GoogleScholar
| Purchase
CHEBI PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Ciba-Geigy Corporation
Curated by ChEMBL
| Assay Description Concentration of the compound necessary to achieve half maximal inhibition of [3H]-clonidine binding to Alpha-2 adrenergic receptor at 1 uM |
J Med Chem 32: 720-7 (1989)
Article DOI: 10.1021/jm00123a039 BindingDB Entry DOI: 10.7270/Q2639NQ6 |
More data for this Ligand-Target Pair | |
Beta-1 adrenergic receptor
(GUINEA PIG) | BDBM50016897
 (2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)Show InChI InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14) | PDB
UniProtKB/TrEMBL
GoogleScholar
| Purchase
CHEBI PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | 6.31E+4 | n/a | n/a | n/a | n/a | n/a |
Institut de Pharmacologie (UA 589 CNRS)
Curated by ChEMBL
| Assay Description The compound was tested for beta-adrenergic activity against Beta-1 adrenergic receptor from guinea pig left atria |
J Med Chem 34: 3197-204 (1991)
Article DOI: 10.1021/jm00115a008 BindingDB Entry DOI: 10.7270/Q2NS0W3J |
More data for this Ligand-Target Pair | |
Beta-1 adrenergic receptor
(GUINEA PIG) | BDBM50016897
 (2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)Show InChI InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14) | PDB
UniProtKB/TrEMBL
GoogleScholar
| Purchase
CHEBI PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | 3.98E+4 | n/a | n/a | n/a | n/a | n/a |
Institut de Pharmacologie (UA 589 CNRS)
Curated by ChEMBL
| Assay Description The compound was tested for beta-adrenergic activity against Beta-1 adrenergic receptor from guinea pig right atria |
J Med Chem 34: 3197-204 (1991)
Article DOI: 10.1021/jm00115a008 BindingDB Entry DOI: 10.7270/Q2NS0W3J |
More data for this Ligand-Target Pair | |