BDBM50106479 CHEMBL384755::FGGFTGARKSARK::H-FGGFTGARKSARK-NH2::N/OFQ(1-13)NH2::NC(1-13)NH2::Nociceptin analogueNC(1-13)-NH2::OFQ/N::Phe-Gly-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-NH2
SMILES [#6]-[#6@@H](-[#8])-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccccc1)-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6@@H](-[#7])-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](-[#7])=O
InChI Key InChIKey=RHMALYOXPBRJBG-CGUXNFSNSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 17 hits for monomerid = 50106479
TargetNociceptin receptor(Homo sapiens (Human))
Louisiana State University
Curated by PDSP Ki Database
Louisiana State University
Curated by PDSP Ki Database
TargetNociceptin receptor(Homo sapiens (Human))
Louisiana State University
Curated by PDSP Ki Database
Louisiana State University
Curated by PDSP Ki Database
Affinity DataKi: 0.350nMAssay Description:Binding affinity to human NOP receptorMore data for this Ligand-Target Pair
TargetNociceptin receptor(Homo sapiens (Human))
Louisiana State University
Curated by PDSP Ki Database
Louisiana State University
Curated by PDSP Ki Database
Affinity DataKi: 0.620nMAssay Description:Displacement of [3H]N/OFQ from human NOP receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.794nMAssay Description:Affinity to nociceptin receptors on mouse forebrain membranes by [3H]NC-NH2 displacement.More data for this Ligand-Target Pair
Affinity DataKi: 0.912nMAssay Description:Inhibition of [3H]NC-NH2 binding to mouse forebrain membranesMore data for this Ligand-Target Pair
TargetNociceptin receptor(Homo sapiens (Human))
Louisiana State University
Curated by PDSP Ki Database
Louisiana State University
Curated by PDSP Ki Database
Affinity DataEC50: 0.324nMAssay Description:Inhibition of forskolin stimulated cAMP accumulation in CHO cells stably expressing the human OP4 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 398nMAssay Description:Activity against LFES-evoked contraction of Wistar rat vas deferens in presence of naloxoneMore data for this Ligand-Target Pair
Affinity DataEC50: 575nMAssay Description:Activity against LFES-evoked contraction of Wistar rat vas deferensMore data for this Ligand-Target Pair
Affinity DataEC50: 51nMAssay Description:Activity at Wistar rat NOP receptor assessed as inhibition of low-frequency electrically-stimulated vas deferens contractionMore data for this Ligand-Target Pair
TargetNociceptin receptor(Homo sapiens (Human))
Louisiana State University
Curated by PDSP Ki Database
Louisiana State University
Curated by PDSP Ki Database
Affinity DataEC50: 8.30nMAssay Description:Agonist activity at NOP (unknown origin) expressed in HEK293 cell membranes co-expressing Gbeta1-RGFP protein assessed as induction of G protein acti...More data for this Ligand-Target Pair
TargetNociceptin receptor(Homo sapiens (Human))
Louisiana State University
Curated by PDSP Ki Database
Louisiana State University
Curated by PDSP Ki Database
Affinity DataEC50: 10nMAssay Description:Agonist activity at NOP (unknown origin) expressed in HEK293 cell membranes co-expressing beta-arrestin2-RGFP protein assessed as induction of beta-a...More data for this Ligand-Target Pair
TargetNociceptin receptor(Homo sapiens (Human))
Louisiana State University
Curated by PDSP Ki Database
Louisiana State University
Curated by PDSP Ki Database
Affinity DataEC50: 7.82nMAssay Description:Agonist activity at human NOP receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
TargetNociceptin receptor(Homo sapiens (Human))
Louisiana State University
Curated by PDSP Ki Database
Louisiana State University
Curated by PDSP Ki Database
Affinity DataEC50: 0.780nMAssay Description:Agonist activity at human NOP receptor by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 11nMAssay Description:Agonist activity at NOR in mouse Neuro-2a cells assessed as stimulation of ERK phopshorylation after 30 mins post dose by Alphascreen Surefire assayMore data for this Ligand-Target Pair
TargetNociceptin receptor(Homo sapiens (Human))
Louisiana State University
Curated by PDSP Ki Database
Louisiana State University
Curated by PDSP Ki Database
Affinity DataEC50: 1.12nMAssay Description:Efficacy for human ORL1 receptor expressing HEK-293 cellsMore data for this Ligand-Target Pair
TargetNociceptin receptor(Homo sapiens (Human))
Louisiana State University
Curated by PDSP Ki Database
Louisiana State University
Curated by PDSP Ki Database
Affinity DataEC50: 0.513nMAssay Description:Agonist activity at human NOP receptor expressed in CHO cells assessed as stimulation of calcium mobilization by Fluo-4 AM dye based analysisMore data for this Ligand-Target Pair
TargetNociceptin receptor(Homo sapiens (Human))
Louisiana State University
Curated by PDSP Ki Database
Louisiana State University
Curated by PDSP Ki Database
Affinity DataIC50: 0.353nMAssay Description:Displacement of [3H]-NC from human ORL1 receptor expressing HEK-293 cell membraneMore data for this Ligand-Target Pair